Polysaccharide dressing for wound repairing and preparation method and application thereof

A wound repair and polysaccharide technology, applied in pharmaceutical formulations, pharmaceutical sciences, bandages, etc., can solve the problems of slow wound healing, frequent dressing changes, and easy generation of drug resistance, so as to promote healing, facilitate application, and promote chronic wound healing. Effect

Inactive Publication Date: 2019-11-05
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine chemical ointments and antibiotics are commonly used to treat wounds in China, but there are disadvantages such as frequent dressing changes, slow wound healing, and easy drug resistance.

Method used

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  • Polysaccharide dressing for wound repairing and preparation method and application thereof
  • Polysaccharide dressing for wound repairing and preparation method and application thereof
  • Polysaccharide dressing for wound repairing and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of fucoidan sulfate methacrylate derivative (FMA1)

[0035] Weigh 2 g of fucoidan sulfate, dissolve it in 100 mL of formamide, and stir evenly to prepare a 2% fucoidan sulfate solution. 12 mL of methacrylic anhydride containing 0.12 g of N-bromosuccinimide (NBS) was added dropwise to the polysaccharide solution, and reacted at 50° C. for 6 h. After the reaction was completed, the precipitate was precipitated with ethanol with a final concentration of 72%, and the precipitate was dissolved in water and dialyzed after drying. After 24 hours, the solution in the dialysis bag (dialysis is dialysis with a 3600Da dialysis bag, tap water for 24 hours, and distilled water for 24 hours) was concentrated under reduced pressure to 1 / 10 of the volume before concentration, and the concentrated solution was freeze-dried to obtain methyl Acrylylated fucoidan sulfate, denoted as FMA1.

Embodiment 2

[0036]Embodiment 2, the preparation of fucoidan sulfate methacrylate derivative (FMA2)

[0037] Weigh 2 g of fucoidan sulfate, dissolve it in 200 mL of formamide, and stir evenly to prepare a 1% fucoidan sulfate solution. 15 mL of methacrylic anhydride containing 0.15 g of N-bromosuccinimide (NBS) was added dropwise to the polysaccharide solution, and reacted at 80° C. for 2 h. After completion of the reaction, precipitate with ethanol with a final concentration of 75%, dissolve the precipitate in water and dialyze after drying. After 24 hours, the solution in the dialysis bag (dialysis is dialysis with a 3600Da dialysis bag, tap water for 24 hours, distilled water for 24 hours) is concentrated under reduced pressure, and the concentrated solution is freeze-dried to obtain methacrylylated fucoidan sulfate, which is designated as FMA2 .

Embodiment 3

[0038] Embodiment 3, the preparation of fucoidan sulfate methacrylate derivative (FMA3)

[0039] Weigh 2 g of fucoidan sulfate, dissolve it in 50 mL of formamide, and stir evenly to prepare a 4% fucoidan sulfate solution. 10 mL of methacrylic anhydride containing 0.10 g of N-bromosuccinimide (NBS) was added dropwise to the polysaccharide solution, and reacted at 40° C. for 8 h. After completion of the reaction, precipitate with ethanol with a final concentration of 80%, dissolve the precipitate in water and dialyze after drying. After 24 hours, dialysis (dialysis is performed with a 3600Da dialysis bag, tap water for 24 hours, distilled water for 24 hours) the solution in the bag is concentrated under reduced pressure, and the concentrated solution is freeze-dried to obtain methacrylylated fucoidan sulfate, which is designated as FMA3 .

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Abstract

The present invention provides a bioactive polysaccharide dressing for wound repair, particularly chronic wound repair, and a preparation method and an application thereof. The preparation method of the dressing of the invention is simple and easy, and the prepared biological dressing has good adhesion, safety, non-toxicity and convenient application. The bioactive fucoidan sulfate hydrogel dressing has the effect of stopping bleeding, moisturizing and promoting chronic wound healing while isolating the wound surface, and has good permeability. The dressing is particularly suitable for the treatment and nursing of chronic refractory wounds which are widely existed in clinical application, especially diabetic ulcers.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a polysaccharide dressing for wound repair (especially chronic wound repair), its preparation method and application. Background technique [0002] With the improvement of human living standards, changes in diet structure and reduction of physical labor, the incidence of diabetes mellitus (DM) continues to rise, and has become one of the three diseases with the highest morbidity and mortality in the world. The increase in patients in developing countries such as China, the Indochina subcontinent and Africa is particularly obvious. According to the survey, about 10% of people over the age of 45 in my country suffer from DM; at present, the number of DM patients in the world has reached 240 million, and it is expected to exceed 300 million in 2025, and the incidence is also becoming younger, seriously affecting human life and health. . Diabetes complicated with refractor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08B37/00
CPCA61L26/0023A61L26/0061A61L26/0066C08B37/0063A61L2300/412A61L2300/236A61L2400/04A61L2300/41C08L5/00
Inventor 王晶张全斌耿丽华岳洋张虹吴宁
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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