Photo-thermal-ion synergistic antibacterial hydrogel as well as preparation method and application thereof

A composite hydrogel and polymer technology, applied in antibacterial drugs, local antibacterial agents, pharmaceutical formulations, etc., can solve the problems of unresolved rapid repair, surrounding tissue damage, cell and tissue toxicity, etc.

Active Publication Date: 2019-11-12
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in fact, when the concentration of copper ions is too high, it will cause toxicity to cells and tissues, and the high temperature generated by light an

Method used

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  • Photo-thermal-ion synergistic antibacterial hydrogel as well as preparation method and application thereof
  • Photo-thermal-ion synergistic antibacterial hydrogel as well as preparation method and application thereof
  • Photo-thermal-ion synergistic antibacterial hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 polydopamine / copper-doped calcium silicate composition

[0055] (1) using amide reaction to graft dopamine and adipic hydrazide on the polyglutamic acid macromolecule long chain, and prepare 5% modified polyglutamic acid solution;

[0056](2) Add copper-doped calcium silicate powder into the modified polyglutamic acid solution, and mix uniformly to obtain a polydopamine / copper-doped calcium silicate composition. The mass fractions of the copper-doped calcium silicate powder in the polydopamine / copper-doped calcium silicate composition are 0.5%, 1%, 2% and 5%, respectively.

[0057] In this system, dopamine interacts with copper-doped calcium silicate: copper-doped calcium silicate produces an alkaline environment to promote the oxidation of dopamine, and at the same time, copper ions in the aqueous solution complex with the generated polydopamine.

[0058] figure 2 The results in (a) and (b) show that copper-doped calcium silicate can generate an alkalin...

Embodiment 2

[0059] The preparation of embodiment 2 polydopamine / copper complex

[0060] (1) using amide reaction to graft dopamine and adipic hydrazide on the polyglutamic acid polymer long chain, and prepare 5% modified polyglutamic acid solution;

[0061] (2) Add 10wt% 1M NaOH solution (100 μL) to 5% modified polyglutamic acid solution (0.5mL) to form polydopamine solution;

[0062] (3) Add 0.5 mL of 0, 1, 20, 50, 500, 1000 ppm copper ion solution (GBW(E) 08027, Shanghai Institute of Measurement and Testing Technology) to polydopamine solution (0.5 mL) to form polydopamine / copper complex.

[0063] figure 2 The results in (c) and (d) show that after the polydopamine is complexed with copper ions, the color and absorbance of the solution change. image 3 The results show that the photothermal performance of the solution is enhanced after complexation.

Embodiment 3

[0064] Embodiment 3 polydopamine / copper-doped calcium silicate composite hydrogel (P / Cu)

[0065] (1) using amide reaction to graft dopamine and adipic hydrazide on the polyglutamic acid polymer long chain, and prepare 5% modified polyglutamic acid solution;

[0066] (2) Using sodium periodate to oxidize the o-diol structure of the dextran polymer to prepare oxidized dextran with aldehyde groups and prepare a 5% solution;

[0067] (3) Add 0.5%, 1%, 2% and 5% copper-doped calcium silicate into the modified polyglutamic acid solution respectively, and mix well. Then add glutamic acid whose mass fraction is 1 / 2 of the mass fraction of copper-doped calcium silicate into the modified polyglutamic acid solution, and adjust the pH to be neutral or weakly alkaline;

[0068] (4) Add an equal volume of prepared oxidized dextran solution to the mixed solution, and gel can be formed within a certain period of time to obtain a polydopamine / copper-doped calcium silicate composite hydrogel....

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Abstract

The invention provides photo-thermal-ion synergistic antibacterial hydrogel as well as a preparation method and application thereof and relates to a polydopamine/copper-doped bioactive ceramic composition. The polydopamine/copper-doped bioactive ceramic composition comprises raw materials as follows: modified polyglutamic acid polymer aqueous solution grafted and modified by dopamine and adipic dihydrazide as well as copper-doped bioactive ceramic powder, wherein the mass percent concentration of the modified polyglutamic acid polymer aqueous solution is 2.5%-10%, and the addition amount of the copper-doped bioactive ceramic powder is 0.5%-5% of the mass of the modified polyglutamic acid polymer aqueous solution.

Description

technical field [0001] The invention relates to a photothermal / ion synergistic antibacterial hydrogel and its preparation method and application, belonging to the fields of biomedicine, material technology, wound repair and medical equipment. Background technique [0002] Wounds caused by fire, mechanical accidents, diseases, etc. are prone to infection, leading to festering and festering of the wound, which is difficult to heal and causes great pain to the patient. How to effectively clear the existing infection, inhibit the growth of bacteria for a long time, and at the same time promote the healing of large-area wounds is of great significance to the treatment of infected wounds, and it is worth exploring and innovating. [0003] Inorganic metal ions, such as copper ions, can inhibit the growth of various bacteria for a long time, and have a good killing effect on some drug-resistant bacteria, but copper ions and bacteria need a long time to achieve the bactericidal effec...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/18A61L15/42A61L15/46A61K41/00A61K33/34A61K9/06A61P31/02A61P17/02A61P31/04C08G69/48
CPCA61K9/06A61K33/34A61K41/0052A61L15/18A61L15/26A61L15/42A61L15/46A61L2300/102A61L2300/404A61L2300/412A61P17/02A61P31/02A61P31/04C08G69/48C08L79/02A61K2300/00
Inventor 常江许晴
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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