Method for testing drug sources based on radioactive carbon isotope

A radioactive carbon and isotope technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to identify the source information, and achieve the effect of objective and accurate test results and reliable drug source information

Inactive Publication Date: 2019-11-15
DALIAN MARITIME UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Above, the current drug detection methods tend to be qualitati

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  • Method for testing drug sources based on radioactive carbon isotope
  • Method for testing drug sources based on radioactive carbon isotope
  • Method for testing drug sources based on radioactive carbon isotope

Examples

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Embodiment

[0035] Samples were taken from seized methamphetamine drugs and dissolved in 1ml buffer consisting of 0.8ml phosphate buffer (0.1molL) and 0.2ml 10% Na 2 CO 3 Solution composition, then add 0.5ml ethyl acetate, vortex extraction for 5min, centrifuge at 3000r / min for 5min, transfer the organic phase to preparative gas chromatography for separation and aggregation. A typical preparative gas chromatography consists of a chromatograph equipped with an autosampler, cold injection system (CIS), large-bore capillary column, GC / MS or FID detector, and a preparative fraction collector (PFC). Automatic The injector enables precise and repeatable injections. CIS can reduce the chance of compound thermal degradation, and its solvent evacuation function makes CIS capable of large volume injection. Wide-bore capillary columns have greater sample capacity and can reduce the number of replicate injections. The detector determines the chromatographic retention time of the target species. P...

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Abstract

The invention discloses a method for testing drug sources based on a radioactive carbon isotope. The method includes the following steps of: performing chemical pretreatment, extraction and centrifugation on a sample; preparing a gas chromatography separation and enrichment target; determining the content of organic compounds 14C and 12C in the target by adopting an accelerator mass spectrometer technology; calculating the respective ratio value of a biological source and an artificial source in the target by using a correlation quantitative method, and judging whether the target is prepared from a fossil source or the biological source according to the ratio value. The scheme of the invention utilizes the principle of a radioactive carbon isotope analysis technology, and analyzes the content of the radioactive carbon isotope to estimate the source of drug raw materials, can provide accurate and objective source information of drug manufacturing, and can provide accurate scientific information for formulating policies to fight against drug manufacturing and drug trafficking, and arranging drug enforcement forces to direct against drug manufacturing behaviors from the source.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a method for detecting the source of drugs based on radioactive carbon isotopes. Background technique [0002] According to the source of drugs, drugs can be divided into three categories: natural drugs, semi-synthetic drugs and synthetic drugs. Natural drugs are those extracted directly from the original plant of the drug, such as cocaine from the coca bush, opium and morphine from the opium poppy, and hashish or marijuana from the cannabis plant. Semi-synthetic drugs are synthesized from natural drugs and chemical substances, such as heroin, which can be made by reacting morphine and acetic anhydride. Synthetic drugs are manufactured entirely by organic synthesis methods, such as ecstasy, LSD, ketamine and other drugs. Different from natural drugs, the production of synthetic drugs does not rely on planting behavior. The required raw materials and ingredients widely exist in peo...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/065
Inventor 王德高郭明星于文静裴伟郑晓雨
Owner DALIAN MARITIME UNIVERSITY
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