Hydrophilic antibacterial degradable ureter stent and preparing method thereof

A ureteral stent and hydrophilic technology, applied in the direction of catheters, coatings, etc., can solve the problems of cytotoxicity, increased active oxygen content, and poor biocompatibility of implants, and achieve the conditions of preventing protein adhesion and modification Mild, low biotoxic effect

Inactive Publication Date: 2019-11-19
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the continuous precipitation and accumulation of antibacterial metal ions or nanoparticles destroys the microenvironmental balance of the surrounding tissue, interferes with the normal growth of surrounding cells, promotes the increase of the content of reactive oxygen spec

Method used

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  • Hydrophilic antibacterial degradable ureter stent and preparing method thereof

Examples

Experimental program
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Example Embodiment

[0039] Example 1

[0040] Such as figure 1 As shown, this embodiment provides a long-acting antibacterial and degradable ureteral stent tube. The specific preparation steps are as follows:

[0041] Step 1: Put the ureteral stent tube made of PGLA (910) into deionized water for ultrasonic cleaning for 15 minutes, and put it in an air laminar flow cabinet to dry; for later use.

[0042] Step 2: Put 0.2g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100mL of deionized water, mix well, and titrate the pH to 8.5 with 0.01M NaOH and 0.01M HCL;

[0043] Step 3: Put the stent tube obtained in step 1 into the solution obtained in step 2, immerse it in an aerobic environment at 37°C for 24 hours and then take it out, ultrasonically clean in deionized water for 20 minutes and then dry;

[0044] Step 4: Dissolve the G3 polyamide-amine dendrimer in deionized water to prepare a 0.5wt% solution;

[0045] Step 5: Put the stent tube obtained in step 3 into the so...

Example Embodiment

[0050] Example 2

[0051] Such as figure 1 As shown, this embodiment provides a hydrophilic, antibacterial and degradable ureteral stent tube, and the specific preparation steps are as follows:

[0052] Step 1: Put the ureteral stent tube made of PGA into deionized water for ultrasonic cleaning for 15 minutes, and put it into the air laminar flow cabinet to dry; for later use.

[0053] Step 2: Put 0.2g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100ml of deionized water, mix well, and titrate the pH to 8.5 with 0.01M NaOH and 0.01M HCL;

[0054] Step 3: Put the stent tube obtained in step 1 into the solution obtained in step 2, immerse it in an aerobic environment at 37°C for 24 hours and then take it out, ultrasonically clean for 20 minutes and then dry;

[0055] Step 4: Dissolve G1 polyamide-amine dendrimer in deionized water to prepare a 3wt% solution;

[0056] Step 5: Put the stent tube obtained in step 3 into the solution obtained in step ...

Example Embodiment

[0061] Example 3

[0062] Such as figure 1 As shown, this embodiment provides a hydrophilic, antibacterial and degradable ureteral stent tube, and the specific preparation steps are as follows:

[0063] Step 1: Put the ureteral stent tube made of PGLA (730) into deionized water for ultrasonic cleaning for 15 minutes, and put it in an air laminar flow cabinet to dry; for later use.

[0064] Step 2: Put 0.4g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100ml of deionized water and mix well, and titrate the pH to 8.5 with 0.01M NaOH and 0.01M HCL;

[0065] Step 3: Put the stent tube obtained in step 1 into the solution obtained in step 2, immerse it in an aerobic environment at 37°C for 24 hours and then take it out, ultrasonically clean for 20 minutes and then dry;

[0066] Step 4: Dissolve the G5 polyamide-amine dendrimer in deionized water to prepare a 0.5wt% solution;

[0067] Step 5: Put the stent tube obtained in step 3 into the solution obta...

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Abstract

The invention provides a hydrophilic antibacterial degradable ureter stent and a preparing method thereof. The surface of the ureter stent is provided with a hydrophilic antibacterial layer, the contact killing effect on bacteria is realized through the effect of polycations of amino-terminated dendrimer, and protein adhesion is prevented by forming a hydration layer. The preparing method includesthe steps of soaking the ureter stent prepared from a degradable material in a Tris-HCl buffer solution of dopamine hydrochloride so that the auto-polymerization of dopamine hydrochloride can happento the surface of the stent, then grafting polyamide-amine dendrimer, and conducting cleaning and drying to obtain the degradable ureter stent grafted with the hydrophilic antibacterial layer. The ureter stent is easy to prepare, the hydrophilic antibacterial layer has a lubricating effect after being reliably grafted on the surface of the stent, the releasing of an antibacterial agent and the toxicity caused by the releasing of the antibacterial agent do not exist, and the ureter stent has high biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical materials and medical devices, and in particular relates to a dendrimer-based highly hydrophilic antibacterial and degradable ureteral stent tube and a preparation method thereof. Background technique [0002] Ureteral stent has dual functions of internal drainage and internal stent. It is a common drainage tool in urology. It is mainly used for dilation treatment of renal ureteral stones, hydronephrosis, ureteral tumors, kidney transplantation and ureteral stricture. [0003] The indwelling time of ureteral stents is generally 2-6 weeks, and the existing clinical ureteral stents are all non-degradable polyurethane stents. After the implantation period, a second operation is required to remove the stent, which will damage the patient's urinary system. If the stent is placed for a long time, it will lead to more serious consequences, such as the loss of renal function, and even the need to remove t...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/08A61L29/14
CPCA61L29/06A61L29/085A61L29/14A61L29/148A61L2420/02C08L67/04C08L79/02
Inventor 王璐高立恒达骏王一惟徐明曦王忠邹婷王富军王李天牧
Owner DONGHUA UNIV
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