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A preparation method and application of graphene oxide@chiral ni-mof hybrid material

A hybrid material and graphene technology, which is applied in the direction of material analysis, material analysis, and material electrochemical variables through electromagnetic means, can solve the problems of high instrument cost, difficulty in in-situ and online detection, and long analysis time. Achieve the effects of high sensitivity, easy operation, simple process and easy control

Active Publication Date: 2021-08-17
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chiral chromatography has been widely used for the separation and analysis of chiral compounds, but this method has certain shortcomings, such as high instrument cost, long analysis time, and it is particularly difficult to realize in-situ and online detection, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 A preparation method of graphene oxide@chiral Ni-MOF hybrid material

[0031] Dissolve 0.30 g of nickel nitrate in 5 mL of water, add 0.1 g of graphene oxide at the same time, and ultrasonicate for 5 min in a 180 W water bath to obtain a nickel nitrate-graphene oxide mixed suspension;

[0032] Dissolve 0.50 mmol of L-tyrosine and 0.50 mmol of sodium hydroxide in 5 mL of water to obtain a clear L-tyrosine alkaline solution;

[0033] Add L-tyrosine alkali solution to nickel nitrate-graphene oxide mixed suspension, stir at room temperature for 45 h, filter with suction, and dry to constant weight at 80°C to prepare graphene oxide-loaded chiral Ni-MOF composite material, namely graphene oxide@chiral Ni-MOF hybrid material.

[0034] The composition of the chiral Ni-MOF belongs to a metal organic framework, and the chemical formula is [Ni (Tyr) 2 2H 2 O] H 2 O, Tyr is L-tyrosine anion; a unit structure of Ni-MOF consists of one Ni (II) ion center, two Tyr anions...

Embodiment 2

[0036] Example 2 A preparation method of graphene oxide@chiral Ni-MOF hybrid material

[0037] Dissolve 0.45 g of nickel nitrate in 7 mL of water, add 0.2 g of graphene oxide at the same time, and ultrasonicate for 7 minutes in a 180 W water bath to obtain a nickel nitrate-graphene oxide mixed suspension;

[0038] Dissolve 0.50 mmol of L-tyrosine and 0.54 mmol of sodium hydroxide in 6 mL of water to obtain a clear L-tyrosine alkaline solution;

[0039] Add L-tyrosine alkali solution to nickel nitrate-graphene oxide mixed suspension, stir at room temperature for 4.5 h, filter with suction, and dry to constant weight at 80°C to prepare graphene oxide-supported chiral Ni-MOF composite material, namely graphene oxide@chiral Ni-MOF hybrid material.

[0040] The composition of the chiral Ni-MOF and the source and properties of graphene oxide are the same as in Example 1.

Embodiment 3

[0041] Example 3 A preparation method of graphene oxide@chiral Ni-MOF hybrid material

[0042] Dissolve 0.60 g of nickel nitrate in 10 mL of water, add 0.3 g of graphene oxide at the same time, and ultrasonicate for 10 min in a 180 W water bath to obtain a nickel nitrate-graphene oxide mixed suspension;

[0043] Dissolve 0.50 mmol of L-tyrosine and 0.58 mmol of sodium hydroxide in 8 mL of water to obtain a clear L-tyrosine alkaline solution;

[0044]Add L-tyrosine alkali solution to nickel nitrate-graphene oxide mixed suspension, stir at room temperature for 4-5 h, filter with suction, and dry at 80°C to constant weight to prepare graphene oxide-supported chiral Ni-MOF The composite material of graphene oxide@chiral Ni-MOF hybrid material;

[0045] The composition of the chiral Ni-MOF and the source and properties of graphene oxide are the same as in Example 1.

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Abstract

The invention discloses a graphene oxide@chiral Ni-MOF hybrid material and its preparation method and the application of the hybrid material for detecting chiral drug enantiomers, belonging to nanocomposite materials, chiral sensing and detection technology field. The main step is to blend the L-tyrosine alkali solution with the nickel nitrate-graphene oxide suspension and react overnight at room temperature to prepare the graphene oxide@chiral Ni-MOF hybrid material. The hybrid material was used to construct a chiral sensor for sensitive detection of the enantiomer content of L-penicillamine and D-penicillamine. The chiral sensor has the advantages of simple method, convenient operation and good chiral detection effect.

Description

technical field [0001] The invention relates to a graphene oxide@chiral Ni-MOF hybrid material and its preparation method and application, and belongs to the technical field of nanomaterials, metal organic framework nanohybrid materials and chiral sensing and detection. Background technique [0002] Chiral metal-organic frameworks (MOFs) are periodic and ordered porous crystalline materials assembled by chiral organic bridging ligands and metal ions or metal clusters through self-assembly. The synthesis operation is relatively simple and the reaction conditions are mild. At present, chiral MOFs have been applied in the fields of heterogeneous asymmetric catalysis and chiral sensing. [0003] The resistivity of graphene oxide is only about 10 -6 Ω cm, lower than copper and silver, is the material with the lowest resistivity found so far; its electron mobility exceeds 15000 cm at room temperature 2 / V·s, much higher than carbon nanotubes and silicon crystals. Due to its low...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C08K3/04G01N27/30G01N27/48
CPCC08G83/008C08K3/042G01N27/308G01N27/48
Inventor 刘昭轩匡轩李文佳
Owner UNIV OF JINAN