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Application of carrageenan oligosaccharide and composition containing carrageenan oligosaccharide

A technology of carrageenan oligosaccharides and compositions, which is applied in the field of preventing hair loss and promoting hair growth, can solve problems that have not been reported yet, and achieve remarkable efficacy, high safety, and good safety effects

Pending Publication Date: 2019-12-06
AQUABRAIN BIOTECH XIAMEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to the connection mode of the monosaccharide and the position of the group, the common carrageenan oligosaccharides mainly include Kappa (κ-), Iota (ι-) and Lambda (λ-) types, but whether it is a single component or The carrageenan oligosaccharides of the mixed components have not been reported for their functions of protecting hair and preventing hair loss

Method used

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  • Application of carrageenan oligosaccharide and composition containing carrageenan oligosaccharide
  • Application of carrageenan oligosaccharide and composition containing carrageenan oligosaccharide
  • Application of carrageenan oligosaccharide and composition containing carrageenan oligosaccharide

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Experimental program
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Effect test

Embodiment 1

[0060] The effect of embodiment 1 carrageenan oligosaccharides on androgenetic alopecia cell model in vitro

[0061] Taking dermal papilla cells as the test object, a certain concentration of dihydrotestosterone (DHT) was used to stimulate the establishment of an in vitro cell model of androgenetic alopecia, and then the in vitro model of androgenetic alopecia was treated with carrageenan oligosaccharides, and minoxidil was used as a positive control. Evaluated by detecting the changes of vascular endothelial growth factor (VEGF), DKK-1, transforming growth factor (TGF-β2), β-catenin (β-catenin) and androgen receptor (AR) secreted by dermal papilla cells Efficacy of κ-carrageenan oligosaccharides in promoting hair regrowth.

[0062] The carrageenan oligosaccharide used in this embodiment has the following two types: (1) κ-carrageenan pentasaccharide (hereinafter referred to as DP5); (2) a mixture of 9 kinds of κ-carrageenan oligosaccharides (hereinafter referred to as DP3-19) ...

Embodiment 2

[0090] Embodiment 2 percutaneous penetration test

[0091] The transdermal penetration test aims to investigate the penetration of carrageenan oligosaccharides on the skin, taking κ-carrageenan pentasaccharide as an example to conduct the following test. Due to the barrier function of skin cells, high concentration of κ-carrageenan pentasaccharide was used to increase the content of κ-carrageenan pentasaccharide in the infiltrated sample to ensure the accuracy of detection. Permeability on the skin served as a control. In addition, it is designed to add penetration enhancers, such as glycerin and non-ionic surfactants (such as polyethylene glycol) to κ-carrageenan pentasaccharide to enhance its transdermal absorption performance. The selection and concentration design of penetration enhancers are shown in the table 3.

[0092] Table 3 Selection and concentration design of penetration enhancer

[0093]

[0094]

[0095] The treated SD rat skin was fixed in the diffusio...

Embodiment 3

[0097] Embodiment 3 mouse hair growth test

[0098] Get 36 guinea pigs, be divided into 6 groups at random (blank group, experimental group 1, 2, 3, 4, 5), each group 6, prepare the medicine used in each group with normal saline as follows: blank group is normal saline, experimental group 1 is κ-carrageenan oligosaccharide (2500ppm), experimental group 2 is iota-carrageenan oligosaccharide (2500ppm), experimental group 3 is λ-carrageenan oligosaccharide (2500ppm), experimental group 4 is κ-carrageenan pentasaccharide (2500ppm), the experimental group 5 was 2500ppm κ-carrageenan pentasaccharide + 2% glycerin + 1% PEG400.

[0099] Inject an appropriate amount of anesthesia into the guinea pigs, and after they are anesthetized, place a 3×3cm 2 Remove the body hair, be careful not to damage the skin, wipe it clean with physiological saline, and put the guinea pig back into the cage. After 24 hours, administer 500 μL of each guinea pig in the hair removal area, apply evenly, once...

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Abstract

The invention relates to application of carrageenan oligosaccharide as a pilatory or hair conditioner and a composition containing the carrageenan oligosaccharide, and specifically relates to application of the carrageenan oligosaccharide in preparation of products for improving and / or promoting hair growth, or eliminating and / or relieving symptoms and diseases related to a poor hair growth state. The composition containing the carrageenan oligosaccharide provided by the invention has obvious hair loss prevention and hair growth promotion effects, has no irritation or side effect, and has high safety.

Description

technical field [0001] The present invention relates to the use of carrageenan oligosaccharides, especially the effect of carrageenan oligosaccharides as an active ingredient for improving hair growth, more particularly the use of carrageenan oligosaccharides for preventing hair loss and promoting hair growth. Background technique [0002] Hair loss and the baldness it causes is a common phenomenon, and the mental stress it causes brings many troubles and obstacles to interpersonal relationships and social life. With the acceleration of the pace of life, the increase of life pressure and environmental pressure, the people suffering from hair loss are getting younger and younger, and not only men, but also women's hair loss is gradually increasing, so there are many therapeutic drugs for preventing hair loss , hair care external products, hair growth external products. [0003] The causes of hair loss are complex and are the combined effects of various factors. The most com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7135A61K31/715A61K8/60A61K8/73A61P17/00A61P17/14A61Q5/12A61Q7/00
CPCA61K31/7135A61K31/715A61P17/14A61P17/00A61K8/73A61K8/60A61Q7/00A61Q5/12
Inventor 张春毅王斐曾翰庭易志伟产竹华曾润颖何雄飞
Owner AQUABRAIN BIOTECH XIAMEN CO LTD
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