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United medicine for resisting human cytomegalovirus (HCMV) and measuring method of component concentration of united medicine

A drug and concentration technology, which is used in the determination/inspection of active ingredients of heterocyclic compounds, microorganisms, antiviral agents, etc.

Inactive Publication Date: 2019-12-20
WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, sodium alginate diester still has a series of problems to be solved, such as the concentration of use, the purity of use, the dosage of medicine, the time of medicine, and the route of medicine.

Method used

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  • United medicine for resisting human cytomegalovirus (HCMV) and measuring method of component concentration of united medicine
  • United medicine for resisting human cytomegalovirus (HCMV) and measuring method of component concentration of united medicine
  • United medicine for resisting human cytomegalovirus (HCMV) and measuring method of component concentration of united medicine

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Embodiment Construction

[0034] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention below will be described in detail with preferred embodiments and accompanying drawings.

[0035] The invention provides a kind of combined anti-HCMV medicine, each part of the medicine is made up of sodium alginate diester, ganciclovir and solvent, and the sodium alginate diester and ganciclovir are freeze-dried and sterilized powder; the solvent is 0.9% Sodium Chloride Injection or 5% Dextrose Injection or 5% Dextrose Sodium Chloride Injection or Normal Saline or Water for Injection, when used, dissolve Diester Sodium Alginate and Ganciclovir in a solvent and make 1mL The injection solution; the concentration of sodium alginate in the injection solution is 312.50 μg / mL-1000.00 μg / mL, and the concentration of ganciclovir is 12.50 μg / mL-63.00 μg / mL.

[0036] For better results, the concentration of diester sodium alginate in each injection is 93...

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Abstract

The invention provides a united medicine for resisting HCMV. Each part of the medicine consists of polysaccharide sulfate, ganciclovir and a solvent, wherein the polysaccharide sulfate and the ganciclovir are freeze-dried sterilization powder, and the solvent is 0.9% sodium chloride injection or 5% glucose injection or 5% glucose and sodium chloride injection or normal saline or water for injection. When the medicine is used, the polysaccharide sulfate and the ganciclovir dissolve in the solvent, and 1mL of injection is prepared; and the concentration of the polysaccharide sulfate in the injection is 312.50 [mu]g / mL-1000.00[mu]g / mL, and the concentration of the ganciclovir is 12.50 [mu]g / mL-63.00[mu]g / mL. The invention aims to solve the problem of determining a marine medicine for resisting HCMV infected livers and of which the main component is the polysaccharide sulfate, and a measuring method of largest non-toxic concentration and the lowest valid concentration of the marine medicine, wherein the lowest dosage of the marine medicine is used in the medication range, and the toxicity of the medicine is reduced as far as possible.

Description

technical field [0001] The invention relates to a method for determining the concentration of a drug and its components, in particular to a method for determining the drug combined with anti-HCMV and its maximum non-toxic concentration and minimum effective concentration. Background technique [0002] Sodium alginate diester is a fucoidan sulfate drug extracted from natural seaweed. Due to its special growth environment, its structure and composition are quite different from terrestrial polysaccharides, and it has unique biological activities: such as anti Oxidation, anti-tumor, anti-virus, anti-coagulation and a series of effects. In addition, sodium alginate diester also has a heparin-like chemical structure and physiological effects, but has no heparin-like toxic side effects. At present, it is commonly used clinically to treat hyperlipidemia, cardiovascular and cerebrovascular diseases, etc. The antiviral effect of fucoidan has attracted more and more public attention....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/737A61K31/522A61P31/20C12Q1/70C12Q1/18C12Q1/02
CPCA61K9/0019A61K9/19A61K31/522A61K31/737A61P31/20C12Q1/18G01N33/5014G01N33/5044G01N2333/045A61K2300/00
Inventor 刘志军邱瑞雪张墨根李文通李宏政李冀琛张曼
Owner WEIFANG MEDICAL UNIV
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