Preparation method and application of thickening agent for emulsion in water

A technology of thickener and water emulsion, applied in the field of thickener preparation of water emulsion, can solve problems such as affecting the dilution and dispersing performance of preparations, easy to mold, and achieve the effects of being conducive to stability, reducing hydrolysis, and improving drug efficacy

Active Publication Date: 2019-12-20
威尔(福建)生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to improve the stability of the water-emulsion preparation system and reduce the possibility of concentration gradient and water separation, it is necessary to add a thickener. Generally, water-soluble thickeners such as ma

Method used

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  • Preparation method and application of thickening agent for emulsion in water
  • Preparation method and application of thickening agent for emulsion in water

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] (1) Add 0.01 mol polyethylene glycol (PEG6000) and 60 g ethyl acetate into a flask with a stirring device, mix them, and use an oil-water separator for dehydration treatment at 77°C for 1 hour;

[0035] (2) After cooling the reaction system to 60°C, fill it with nitrogen, add 0.01 mol of diisocyanate (HDI), and then react at 60°C for 4.5 hours, then add 0.005 mol of castor oil polyether benzoic acid diester-01 , Then continue to react at 60°C for 5h, and finally add 0.0015mol of castor oil polyether salicylic acid monoester-01 to react. When infrared chromatography detects that there is no free isocyanate group, the reaction ends;

[0036] (3) Add 288.2g of deionized water to the product solution obtained in step (2), then heat to 98°C for azeotropic treatment, remove the organic solvent through an oil-water separator, and then supplement the lost water, and then cool the reaction system to At room temperature, an aqueous emulsion thickener with a solid con...

Example Embodiment

[0037] Example 2

[0038] (1) Add 0.01 mol polyethylene glycol (PEG8000) and 240 g acetone to a flask with a stirring device, mix them, and use an oil-water separator for dehydration treatment at 57°C for 5 hours;

[0039] (2) After cooling the reaction system to 50°C, fill it with nitrogen, add 0.01 mol of diisocyanate (HDI), then react at 60°C for 4.5 hours, then add 0.0075 mol of castor oil polyether benzoic acid diester-02 , Then continue the reaction treatment at 50 ℃ for 5h, and finally add 0.0025mol castor oil polyether salicylic acid monoester-02 to react, when infrared chromatography detects that there is no free isocyanate group, the reaction ends;

[0040] (3) Add 122.4g of deionized water to the product solution obtained in step (2), then heat to 98°C for azeotropic treatment, remove the organic solvent through an oil-water separator, and then supplement the lost water, and then cool the reaction system to At room temperature, a water emulsion thickener with a solid cont...

Example Embodiment

[0041] Example 3

[0042] (1) Add 0.01 mol polyethylene glycol (PEG4000) and 25 g of toluene into a flask with a stirring device, mix well, and use an oil-water separator for dehydration treatment at 57°C for 5 hours;

[0043] (2) After cooling the reaction system to 50°C, fill it with nitrogen, add 0.01 mol of diisocyanate (HDI), then react at 60°C for 4.5 hours, then add 0.0015 mol of castor oil polyether benzoic acid diester-02 , Then continue to react at 50 ℃ for 5 hours, and finally add 0.0005 mol of castor oil polyether salicylic acid monoester-01 to react. When infrared chromatography detects that there is no free isocyanate group, the reaction ends;

[0044] (3) Add 48.6g of deionized water to the product solution obtained in step (2), then heat to 98°C for azeotropic treatment, remove the organic solvent through an oil-water separator, and then supplement the lost water, and then cool the reaction system to At room temperature, a water emulsion thickener with a solid conten...

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Abstract

The invention discloses a preparation method and application of a thickening agent for an emulsion in water. The preparation method comprises the steps: dehydrating polyethylene glycol by using an organic solvent with a boiling point being lower than 110 DEG C; then, adding diisocyanate under the protection of a reactive shielding gas to carry out reaction treatment; next, adding castor oil polyether diester benzoate serving as an end-capping agent to carry out a further reaction; then, adding polyhydroxyl-containing castor oil polyether monosalicylate serving as a chain extender, carrying outa reaction on a reaction system until no free isocyanate groups exist, and then, adding water to azeotropically remove the organic solvent to prepare the thickening agent. The thickening agent for the emulsion in water, prepared according to the scheme, is a white thick liquid so as to be directly used without swelling; in addition, no catalysts are used in the scheme, so that the hydrolysis of polyurethane in storage and use is reduced, and the stability can be favorably realized; and the prepared emulsion in water is good in dispersibility and stability, not only improved on adhesive power,but also resistant to rainwash and beneficial to better realization of a pesticide effect.

Description

technical field [0001] The invention belongs to the field of pesticides or pesticide adjuvants, and in particular relates to a preparation method and application of a thickener for emulsion in water. Background technique [0002] Emulsion in water (EW), also called concentrated emulsion (CE), is a kind of pesticide preparation formed by dispersing the liquid obtained by dissolving water-insoluble liquid raw medicine or low-melting solid raw medicine in water-insoluble organic solvent in water. Nowadays, water emulsion is a new dosage form in which water is used instead of the organic solvent in the emulsifiable concentrate as the medium. It is safer than emulsifiable concentrate in processing, storage, transportation, and packaging. It is non-irritating and has very low transdermal toxicity to humans. It is an excellent, safe and environmentally friendly pesticide water-based preparation that replaces emulsifiable concentrate. [0003] In order to improve the stability of t...

Claims

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Application Information

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IPC IPC(8): C08G18/48C08G18/67A01N25/24A01N25/04
CPCA01N25/04A01N25/24C08G18/4833C08G18/6795
Inventor 倪素美吴钟芳张建冬黄子发
Owner 威尔(福建)生物有限公司
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