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A self-driven artificial intelligence material, preparation method and application in imaging analysis detection and drug controlled release

An artificial intelligence and self-driven technology, which is applied in the direction of material analysis, drug combination, and analysis of materials through optical means, can solve the problems of high external environmental requirements, cumbersome preparation methods, and restricted development, and achieve low external environmental requirements. Good biocompatibility, good self-deformation ability

Active Publication Date: 2020-09-01
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of micromotor is small in size and fast in motion, it has high requirements on the external environment and can only move in a hydrogen peroxide solution, and the preparation method is cumbersome. Most of them use methods such as sputtering coating, photoetching, and electrochemical deposition. preparation, which greatly limits its development in practical applications

Method used

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  • A self-driven artificial intelligence material, preparation method and application in imaging analysis detection and drug controlled release
  • A self-driven artificial intelligence material, preparation method and application in imaging analysis detection and drug controlled release
  • A self-driven artificial intelligence material, preparation method and application in imaging analysis detection and drug controlled release

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Embodiment 1

[0045] A method for preparing a self-driven artificial intelligence material that can be used for imaging, analytical sensing and detection, comprising the following steps:

[0046] (1) Weigh 1 g of chitosan solution and disperse it in 100 ml of deionized water, add 0.8 ml of acetic acid solution, and stir at room temperature for 6 hours to obtain chitosan acetic acid aqueous solution, which is stored in a refrigerator at 4°C. Weigh 2 g of carboxymethyl chitosan powder and disperse it in 100 ml of deionized water, stir at room temperature for 4 hours to obtain a carboxymethyl chitosan solution, which is also stored in a refrigerator at 4°C.

[0047] (2) Weigh 0.2g EDTA disodium salt and dissolve it in 100ml deionized water, stir at room temperature for 0.5h, then add 0.5g FeCl 3 ·6H 2 O, after continuing to stir at room temperature for 1h, EDTA-Fe was obtained 3+ solution, ready to use.

[0048] (3) Weigh 2 g of sodium dodecyl sulfate (SDS) and disperse it in 100 ml of deio...

Embodiment 2

[0054] A method for preparing a self-driven artificial intelligence material that can be used for imaging, analytical sensing and detection, comprising the following steps:

[0055] (1) Weigh 3g of chitosan solution and disperse it in 100ml of deionized water, add 1.5ml of acetic acid solution, stir at room temperature for 24 hours to obtain chitosan acetic acid aqueous solution, and store in a refrigerator at 4°C. Weigh 10 g of carboxymethyl chitosan powder and disperse it in 100 ml of deionized water, stir at room temperature for 12 hours to obtain a carboxymethyl chitosan solution, which is also stored in a refrigerator at 4°C.

[0056] (2) Weigh 3g of EDTA disodium salt and dissolve it in 100ml of deionized water, stir at room temperature for 2h, then add 7g of FeCl 3 ·6H 2 O, after continuing to stir at room temperature for 3h, EDTA-Fe was obtained 3+ solution, ready to use.

[0057] (3) Weigh 10 g of sodium dodecyl sulfate (SDS) and disperse it in 100 ml of deionized ...

Embodiment 3

[0061] A method for preparing a self-driven artificial intelligence material that can be used for imaging, analytical sensing and detection, comprising the following steps:

[0062] (1) Weigh 2 g of chitosan solution and disperse it in 100 ml of deionized water, add 1 ml of acetic acid solution, stir at room temperature for 12 hours to obtain chitosan acetic acid aqueous solution, and store in a refrigerator at 4°C. Weigh 5 g of carboxymethyl chitosan powder and disperse it in 100 ml of deionized water, stir at room temperature for 8 hours to obtain a carboxymethyl chitosan solution, which is also stored in a refrigerator at 4°C.

[0063] (2) Weigh 1g of ethylenediaminetetraacetic acid disodium salt and dissolve it in 100ml of deionized water, stir at room temperature for 1h, then add 1.5g of FeCl 3 ·6H 2 O, after continuing to stir at room temperature for 2h, EDTA-Fe was obtained 3+ solution, ready to use.

[0064] (3) Weigh 5 g of sodium dodecyl sulfate (SDS) and disperse...

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Abstract

The invention discloses a self-driving type artificial intelligence material, a preparation method and application in imaging analysis detection and drug controlled release. According to the self-driving type artificial intelligence material, the preparation method and application in imaging analysis detection and drug controlled release, chitosan and carboxymethyl chitosan are taken as a substrate, the substrate is wrapped with a surfactant, chloroauric acid is reduced, and the nano-gold self-driving artificial intelligence material is prepared. Due to the self-driving performance of the material, the nano-gold artificial intelligence material can smoothly enter the position that a traditional material cannot reach. In addition, nano gold is easy to chemically modify and has the characteristics of good biocompatibility, excellent biological inertia, surface plasmon resonance and the like, and the prepared self-driving type artificial intelligence material has a good application prospect in the fields of imaging, analysis and sensing, detection, drug site-directed delivery and the like.

Description

technical field [0001] The invention belongs to the field of intelligent polymer materials, and in particular relates to a self-driven artificial intelligence material, a preparation method and an application in imaging analysis detection and drug controlled release. Background technique [0002] Self-propelled artificial intelligence materials have received extensive attention in the fields of drug delivery, analytical sensing, and environmental governance due to their autonomous movement characteristics. At present, most self-propelled materials are tubular or spherical Janus micromotors with multilayer metal structures composed of Ti, Fe, Au, Ag, Pt, etc., which provide propulsion power based on the generation of bubbles by catalyzing the decomposition of hydrogen peroxide. Although this type of micromotor is small in size and fast in motion, it has high requirements on the external environment and can only move in a hydrogen peroxide solution, and the preparation method ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08K3/08C08J9/28C08J3/075G01N21/84A61K9/06A61K47/36A61K47/02A61K31/704A61P35/00
CPCA61K9/06A61K31/704A61K47/02A61K47/36A61P35/00C08J3/075C08J9/28C08J2201/0484C08J2205/026C08J2305/08C08J2405/08C08K2003/0806C08K2201/011C08L5/08C08L2205/025G01N21/84C08K3/08
Inventor 蒋刚彪李曾林胡甜刘永林胡汉剑
Owner SOUTH CHINA AGRI UNIV