The detection method of 16 local anesthesia ingredients in an adult external product

A detection method and local anesthesia technology, which can be used in measurement devices, material separation, and analysis of materials, etc., can solve the problem of lack of uniform quality standards for adult external products, and achieve the effects of strong practicability, improved sensitivity, and simple operation process.

Active Publication Date: 2022-05-10
广东省药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no uniform quality standard for adult topical products. In order to ensure the follow-up research and production quality of adult topical products, it is necessary to carry out quality control on the anesthetic components of adult topical products.

Method used

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  • The detection method of 16 local anesthesia ingredients in an adult external product
  • The detection method of 16 local anesthesia ingredients in an adult external product
  • The detection method of 16 local anesthesia ingredients in an adult external product

Examples

Experimental program
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Effect test

Embodiment 1

[0032] High performance liquid chromatography analysis method

[0033] Instruments and conditions:

[0034] Shimadzu LC 20-AT high performance liquid chromatograph (with diode array detector). Methanol is chromatographically pure; phosphoric acid, dipotassium hydrogen phosphate and sodium heptanesulfonate are analytically pure. The ingredients of local anesthesia are listed in Table 1.

[0035] Table 1. 16 local anesthetic standard substances

[0036]

[0037] Chromatographic column: Agilent Poroshell 120 EC-C18 (50mm×4.6mm, 2.7μm);

[0038] Flow rate: 1.5 mL / min;

[0039] Column temperature: 35°C;

[0040] Injection volume: 10 μL;

[0041] Qualitative analysis wavelength range is 200~400nm, quantitative analysis wavelength is 210nm (lidocaine, prilocaine, ropivacaine, bupivacaine and pramoxine) and 280nm (procainamide, procaine chloroprocaine, benzocaine, buprocaine, oxybucaine, tetracaine, eugenol, dibucaine, eugenol methyl ether and isoeugenol methyl ether);

[0...

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Abstract

The invention discloses a high-performance liquid chromatography method for detecting 16 kinds of local anesthetic components in adult products for external use. The high-performance liquid chromatography is used for detection, and the detection includes the following steps: firstly preparing a test solution; and then using high-performance liquid chromatography to detect The test solution is tested; a sub-3 micron core-shell column is used, which is suitable for the detection of 16 local anesthetic components. The present invention improves the sample processing, improves the detection recovery rate and accuracy through the setting of the chromatographic column and the chromatographic analysis conditions, makes the operation process simpler and faster, can significantly improve the sensitivity of the detection method, and has strong practicability. It is an external product for adults Provide support for the prevention and control of 16 local anesthetic component residues.

Description

technical field [0001] The invention belongs to the field of drug analysis and detection, and relates to a detection method for 16 kinds of local anesthetic components in adult external products. Background technique [0002] With the improvement of people's living standards, there are more and more types of adult products. After years of inspections, the non-addition phenomenon of oral aphrodisiac products has been controlled, but some external products for adults such as lubricating oil, wet wipes and delay sprays have not been effectively supervised. Unscrupulous businesses will use adult products externally and illegally add local anesthetic ingredients to make huge profits. Long-term heavy use by consumers may cause adverse reactions such as dizziness, muscle twitching, and numbness of limbs, and may even cause serious consequences such as epilepsy and cardiac arrhythmia, endangering consumers' physical and mental health. [0003] Local anesthetics are a class of drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 黄艳婷庄玥邱蕴绮
Owner 广东省药品检验所
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