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Ultrasonoscopy nanocapsules and preparation method thereof

A technology of nanocapsules and ultrasound, which is applied in the fields of polymer chemistry and biomedical engineering, can solve the problems of short survival time of contrast agents, breaking the shell of contrast agents, and enlargement of contrast agents, so as to achieve improved thermal and mechanical properties, The effect of improving stability and prolonging development time

Active Publication Date: 2019-12-24
SOUTH CHINA NORMAL UNIVERSITY +2
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  • Abstract
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Problems solved by technology

[0007] However, a common problem in current research reports and clinical applications is that the survival time of the contrast agent in the body is short. With the vaporization of the fluorocarbon droplets, the contrast agent becomes larger and finally bursts the contrast agent shell.
Therefore, clinically, in order to prolong the imaging time, doctors will continuously inject contrast agents into patients, which also brings higher treatment costs.

Method used

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  • Ultrasonoscopy nanocapsules and preparation method thereof
  • Ultrasonoscopy nanocapsules and preparation method thereof
  • Ultrasonoscopy nanocapsules and preparation method thereof

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Embodiment 1

[0031] 1. Preparation of amphiphilic block copolymers PEG-PLLA and PEG-PDLA:

[0032]Weigh 1.0g mPEG (molecular weight: 2.0kg / mol), add it to a 50mL reaction bottle, heat and vacuum dry at 60°C for at least 2h, and cool to room temperature; weigh 5.0g L-lactide under the protection of argon, Add a small amount of stannous octoate (5 μL) into the reaction bottle, and dry it in vacuum at room temperature for at least 1 hour; under the protection of dry argon, add 15 mL of anhydrous toluene to dissolve; reflux reaction for 12 hours under heating in an oil bath at 120 ° C; after the reaction, put Drop the toluene solution of the product into icy anhydrous ether for reprecipitation, filter with suction, dissolve the precipitate with dichloromethane, reprecipitate twice in hexane with ice, filter with suction and dry in vacuum to obtain the final sample PEG-PLLA ;

[0033] Using D-lactide instead of L-lactide, the amphiphilic block copolymer PEG-PDLA was prepared by a similar metho...

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Abstract

The invention discloses ultrasonoscopy nanocapsules and a preparation method thereof. The ultrasonoscopy nanocapsules present a core / shell structure, shell-layer materials are amphipathic block copolymers, and kernel materials are liquid fluorine-carbon type ultrasonoscopy reagents; the amphipathic block copolymers include hydrophilic chain segments and hydrophobic chain segments, the hydrophilicchain segments are selected from non-ion type water-soluble polymers, the hydrophobic chain segments are polylactic acid, and the polylactic acid includes levorotary polylactic acid and dextrorotatorypolylactic acid. In the manner, the ultrasonoscopy nanocapsules are nanometer-level, and are narrow in particle size distribution, excellent in thermology properties and high in stability.

Description

technical field [0001] The invention relates to the fields of polymer chemistry and biomedical engineering, in particular to an ultrasonic imaging nanocapsule and a preparation method thereof. Background technique [0002] Ultrasound is one of the most commonly used and most important medical imaging methods. Compared with other imaging methods, it has the advantages of being more economical, more convenient, radiation-free, repeatable for multiple inspections, and used at the bedside and during surgery. Therefore, clinical application Widespread and high popularity. [0003] The emergence and development of ultrasound contrast agents and imaging techniques have brought opportunities for ultrasound molecular imaging. The currently commonly used ultrasound contrast agent belongs to the blood pool imaging agent. The microbubble diameter of the contrast agent (generally a few microns) is close to the size of red blood cells. Improve the acoustic impedance difference of the in...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/225
Inventor 李皓付佳伟陈鑫周国富
Owner SOUTH CHINA NORMAL UNIVERSITY
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