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Tea polyphenol-based multifunctional nano-composite as well as preparation method and application thereof

A technology of functional nanometers and tea polyphenols, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve the problems of waste of raw materials, difficulty in ensuring the content rate of tea polyphenols, etc., so as to avoid energy-consuming equipment, The effect of short time and simple operation

Active Publication Date: 2019-12-31
SICHUAN UNIV
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned methods for preparing nanoparticles from tea polyphenols all require a multi-step, long-term synthesis process, and some preparation methods do not use tea polyphenols as raw materials to directly prepare nanoparticles, but load tea polyphenols into the synthetic On the organic carrier, it is not only difficult to ensure the content of tea polyphenols, but also causes a great waste of raw materials in the later separation process
[0005] Therefore, the preparation process of multifunctional nanoparticles using tea polyphenols as raw materials is still in the process of exploration and research. How to prepare tea polyphenols-based multifunctional nanoparticles with high yield is still a research difficulty in the field of biomaterials technology.

Method used

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  • Tea polyphenol-based multifunctional nano-composite as well as preparation method and application thereof
  • Tea polyphenol-based multifunctional nano-composite as well as preparation method and application thereof
  • Tea polyphenol-based multifunctional nano-composite as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1- Embodiment 8

[0039] Embodiment 1-Example 8 amino acid-tea polyphenol nanocomposite

[0040] The method for preparing the amino acid-tea polyphenol nanocomposite in the following examples 1-embodiment 8 is as follows: 10 parts by weight of tea polyphenols, 1 to 5 parts by weight of amino acids and 1 part by weight of formaldehyde are dissolved in deionized water to form a reaction system, and then Stir the reaction system at 25°C until the reaction system is milky white to complete the reaction, then centrifuge the obtained reaction solution for solid-liquid separation, wash the separated solid product with deionized water, and freeze-dry to obtain the amino acid-tea polyphenol nanocomposites. The ratio of raw materials used in the above preparation process, process parameters and representative parameters of the obtained products are shown in Table 1.

[0041] Table 1: Raw material ratio (parts by weight) and process parameters

[0042]

[0043] Note: EGCG (epigallocatechin gallate) w...

Embodiment 9- Embodiment 11

[0048] Example 9-Example 11 NH 2 -PEG-OH-tea polyphenol nanocomposite

Embodiment 9- Embodiment 10

[0049] The following examples 9-embodiment 10 prepare NH 2 The method of -PEG-OH-tea polyphenol nanocomposite is as follows: 10 parts by weight of EGCG, 1~10 parts by weight of HO-PEG-NH 2 (Amino-terminated polyethylene glycol) and 0.1 to 2 parts by weight of formaldehyde are dissolved in deionized water to form a reaction system, and then the reaction system is stirred at 25°C until the reaction system is milky white to complete the reaction, and then the obtained reaction solution is centrifuged. Solid-liquid separation, and the separated solid product was washed with deionized water and freeze-dried to obtain NH 2 -PEG-tea polyphenol nanocomposite. The ratio of raw materials used in the above preparation process, process parameters and representative parameters of the obtained products are shown in Table 2.

[0050] Table 2: Raw material ratio (parts by weight) and process parameters

[0051]

[0052] Note: HO-PEG-NH 2 (amino-terminated polyethylene glycol) was purch...

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Abstract

The invention discloses a tea polyphenol-based multifunctional nano-composite as well as a preparation method and an application thereof. In the presence of aldehyde-based compounds, tea polyphenol and an amino compound / sulfydryl compound are quickly subjected to an assembly reaction, the tea polyphenol-based multifunctional nano-composite is formed, the reaction temperature is low and the reaction time is short, the influence on the activity of functional molecules such as tea polyphenol, the amino compound / sulfhydryl compound and the like is greatly reduced, according to the preparation method, the free radical scavenging capacity of tea polyphenol can be brought into full play, and the introduced amino compound or sulfydryl compound can enable the obtained nano-composite to have fluorescence, reduction responsiveness and targeting property, so that the obtained nano-composite shows various excellent properties.

Description

technical field [0001] The invention belongs to the technical field of nano functional biomaterials, and relates to a method for preparing a multifunctional nanocomposite based on tea polyphenols and an application of the multifunctional nanocomposite. Background technique [0002] Oxidative damage is one of the greatest threats to human health, and oxygen free radicals are the main cause of oxidative damage. Oxygen free radicals not only accelerate aging, but are also associated with many aging-related diseases, such as atherosclerosis, hypertension, osteoarthritis, cataracts, and Parkinson's disease. Antioxidants help to improve the body's antioxidant capacity, and play a very important role in the prevention and treatment of various oxidative damage-related diseases. As an antioxidant, nano-antioxidant materials can not only capture oxygen free radicals or reduce the production rate of oxygen free radicals, but also avoid being eliminated by the body's rapid metabolism c...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/18A61K47/22A61K47/10A61K47/08A61K31/353A61P35/00
CPCA61K9/5123A61K9/5146A61K31/353A61P35/00
Inventor 李旭东易增陈光灿陈翔宇马晓敏崔新星苏文
Owner SICHUAN UNIV
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