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Completely degradable bone repairing material and preparation method thereof

A repair material and bone repair technology, applied in prosthesis, tissue regeneration, medical science, etc., can solve problems such as easy disinfection, and achieve the effect of promoting adhesion, bone regeneration, and bone defect repair

Inactive Publication Date: 2020-01-17
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (6) Ease of disinfection

Method used

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  • Completely degradable bone repairing material and preparation method thereof
  • Completely degradable bone repairing material and preparation method thereof
  • Completely degradable bone repairing material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Take 30 mg of black phosphorus, add 400 mL of N-methylpyrrolidone (NMP) solvent and place it in a cell pulverizer for peeling, the ultrasonic power is 800w, and the solution A is obtained after ultrasonic peeling for 180 minutes;

[0056] (2) Solution A is placed in an ultrasonic machine to continue ultrasonic dispersion, the ultrasonic power is 200w, and the ultrasonic time is 6h, to obtain uniformly dispersed black phosphorus nano-multi-lamellar-NMP solution B;

[0057] (3) Suction filtration is carried out to solution B, and NMP is refluxed, obtains the black phosphorus nanometer multi-sheet C that is dispersed uniformly;

[0058] (4) Take the black phosphorus nano-multi-sheet C and place it in a trifluoroethanol solvent, and fully ultrasonically disperse it to dissolve it to obtain a saturated solution D whose concentration is 2.5 mg / ml;

[0059] (5) 1.08 g of polycaprolactone and 0.72 g of gelatin were dissolved in 28.2 g of trifluoroethanol, and magnetically s...

Embodiment 2

[0064] (1) Take 30 mg of black phosphorus, add 400 mL of N-methylpyrrolidone (NMP) solvent and place it in a cell pulverizer for peeling, the ultrasonic power is 800w, and the solution A is obtained after ultrasonic peeling for 180 minutes;

[0065] (2) Solution A is placed in an ultrasonic machine to continue ultrasonic dispersion, the ultrasonic power is 200w, and the ultrasonic time is 6h, to obtain nano-multi-lamellar-NMP solution B of uniformly dispersed black phosphorus;

[0066] (3) Suction filtration is carried out to solution B, and NMP is refluxed, obtains the black phosphorus nanometer multi-sheet C that is dispersed uniformly;

[0067] (4) Take the nano-multi-sheet C of black phosphorus and place it in a trifluoroethanol solvent, and fully ultrasonically disperse it to dissolve it to obtain a saturated solution D whose concentration is 2.0 mg / ml;

[0068] (5) 1.44 g of polycaprolactone and 0.96 g of gelatin were dissolved in 27.6 g of trifluoroethanol, and magnetic...

Embodiment 3

[0073] (1) Take 30 mg of black phosphorus, add 400 mL of N-methylpyrrolidone (NMP) solvent and place it in a cell pulverizer for peeling, the ultrasonic power is 800w, and the solution A is obtained after ultrasonic peeling for 180 minutes;

[0074] (2) Solution A is placed in an ultrasonic machine to continue ultrasonic dispersion, the ultrasonic power is 200w, and the ultrasonic time is 6h, to obtain uniformly dispersed black phosphorus nano-multi-lamellar-NMP solution B;

[0075] (3) Suction filtration is carried out to solution B, and NMP is refluxed, obtains the black phosphorus nanometer multi-sheet C that is dispersed uniformly;

[0076] (4) Take the black phosphorus nanometer multi-sheet C and place it in a trifluoroethanol solvent, and fully ultrasonically disperse it to dissolve it to obtain a saturated solution D whose concentration is 2.0 mg / ml;

[0077] (5) Dissolve 1.8 g of polylactic acid and 1.2 g of gelatin in 27 g of trifluoroethanol, and stir magnetically at...

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Abstract

The invention relates to a completely degradable bone repairing material and a preparation method thereof, and belongs to the field of biomaterials. The repairing material takes degradable aliphatic polyester with biocompatibility and a natural degradable polymer as main raw materials, a black phosphorus nanometer multi-sheet layer capable of being completely biodegradable and accelerating bone formation is added, and an electrostatic spinning, solution pouring or 3D printing method is adopted to prepare the bone repairing material. The bone repairing material disclosed by the invention exhibits excellent complete degradability, bone defect repairing can be accelerated, a secondary operation is not required, and a problem that the bone repairing material is insufficient and incomplete in degradation in a body can be solved.

Description

technical field [0001] The invention belongs to the field of biomaterials, and specifically relates to a nano-multi-sheet bone repair material which takes fibers formed of degradable aliphatic polyester and natural degradable polymers as the main matrix material and adds bone-promoting black phosphorus and its Preparation. Background technique [0002] The repair of bone defects caused by tumors, tuberculosis, trauma and metabolic bone diseases has always been one of the difficult problems in the field of surgery. Currently commonly used methods such as autologous bone graft, allogeneic bone graft, and non-tissue repair have some problems to varying degrees. For example, autologous bone sources are extremely limited and cannot be used to repair large-scale bone defects; allogeneic bone has immune rejection and may cause pathogen infection (such as HIV virus, hepatitis virus infection, etc.); non-tissue repair is usually used for joint replacement surgery, Inability to inte...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/18A61L27/22A61L27/20A61L27/12A61L27/54
CPCA61L27/12A61L27/18A61L27/20A61L27/222A61L27/227A61L27/54A61L27/58A61L2300/112A61L2300/412A61L2430/02C08L67/04C08L5/08C08L1/02C08L3/02C08L5/04C08L89/00
Inventor 张立群万鹏博郑静宫敏池骋谢纹奇
Owner BEIJING UNIV OF CHEM TECH
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