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Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof

A polytetrafluoroethylene, surface modification technology, applied in the direction of fiber type, fiber treatment, biochemical fiber treatment, etc., can solve the problems of prosthesis failure, obstructive thrombus, and failure to achieve adhesion, so as to promote proliferation and promote Effect of endothelialization and accelerated adhesion

Pending Publication Date: 2022-03-01
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a surface-modified polytetrafluoroethylene fiber membrane and a preparation method thereof, the purpose of which is to solve the problem that the lack of a stable endothelial inner layer may lead to obstructive thrombus and false in the existing tissue regeneration technology. body failure, thereby failing to achieve good adhesion technical issues

Method used

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  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof
  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof
  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof

Examples

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Effect test

Embodiment 1

[0025] The preparation method of the surface-modified polytetrafluoroethylene fiber membrane provided by this embodiment, the specific technical scheme is as follows:

[0026] (1) Preparation of composite nanofiber membrane:

[0027] 4 mL of 5% PVA solution, 20 μL of 10% boric acid solution and 2 g of PLGA were added to 50 mL of 40% PTFE emulsion, mixed, and stirred at room temperature for 24 hours to obtain a spinning solution. The spinning solution was transferred to a 30mL syringe with a needle of 0.6cm to start high-voltage electrospinning, the spinning voltage was set to 40kV, the distance from the syringe needle to the receiving drum was 30cm, the ambient temperature was controlled at 22°C, and the humidity was 45%. After spinning, the electrospun fiber base film is taken out from the drum. Soak the electrospun fiber base membrane in a container filled with purified water for 6 hours, then ultrasonically clean it for 20 minutes, rinse it with ethanol three times, and fi...

Embodiment 2

[0032] The present embodiment provides the preparation method of surface modified polytetrafluoroethylene fiber membrane, and specific technical scheme is as follows:

[0033] (1) Preparation of composite nanofiber membrane:

[0034] Add 10 mL of 10% PVA solution, 160 μL of 5% boric acid solution and 2 g of PLGA into 60% and 50 mL of PTFE emulsion, mix and stir at room temperature for 24 hours to obtain a spinning solution. The spinning solution was transferred to a 30mL syringe with a needle of 0.8cm to start high-voltage electrospinning, the spinning voltage was set to 30kV, the distance from the syringe needle to the receiving drum was 20cm, the ambient temperature was controlled at 20°C, and the humidity was 40%. After spinning, the electrospun fiber base film is taken out from the drum. Soak the electrospun fiber base membrane in a container filled with purified water for 6 hours, then ultrasonically clean it for 10 minutes, rinse it with ethanol three times, and finally...

Embodiment 3

[0039] The present embodiment provides the preparation method of surface modified polytetrafluoroethylene fiber membrane, and specific technical scheme is as follows:

[0040] (1) Preparation of composite nanofiber membrane:

[0041] Add 2 mL of 15% PVA solution, 200 μL of 2% boric acid solution and 2 g of PLGA into 80% and 12.5 mL of PTFE emulsion, mix and stir at room temperature for 24 hours to obtain a spinning solution. The spinning solution was transferred to a 30mL syringe with a needle of 0.6cm to start high-voltage electrospinning, the spinning voltage was set to 40kV, the distance from the syringe needle to the receiving drum was 30cm, the ambient temperature was controlled at 22°C, and the humidity was 45%. After spinning, the electrospun fiber base film is taken out from the drum. Soak the electrospun fiber base membrane in a container filled with purified water for 6 hours, then ultrasonically clean it for 3 minutes, rinse it with ethanol for 3 times, and finally d...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a surface modified polytetrafluoroethylene fiber membrane and a preparation method thereof. According to the invention, a PTFE / PLGA composite nanofiber membrane is obtained by adopting a high-voltage electrostatic spinning method, and REDV is selectively fixed by modifying the nanofiber membrane, so that a biological material is functionalized. The surface modified and grafted fiber membrane can induce selective endothelial cells (ECs) to be effective, accelerate adhesion and promote endothelialization, meanwhile promotes proliferation of functional decellularized tissues used for blood contact application, and is a partially absorbable composite fiber membrane with very high application potential in the medical field of surgical hernia repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a surface-modified polytetrafluoroethylene fiber membrane and a preparation method thereof. Background technique [0002] Guided Tissue Regeneration (GTR) is a biological concept proposed by Nyman et al. in the early 1980s. Guided tissue regeneration membrane materials are the key to GTR technology. First of all, these materials should have good tissue compatibility and no cytotoxicity. , do not cause rejection, and secondly, its implantation in the body should be able to be absorbed by the tissue, and can be completely replaced by bone tissue, and the degradation rate of the membrane should match the tissue regeneration time. But the lack of a stable endothelial lining may affect the hemocompatibility of synthetic and biological alternatives. Typically, medical devices such as vascular grafts, stents, and glutaraldehyde-treated prosthetic heart valves h...

Claims

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Application Information

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IPC IPC(8): D06M16/00D01F8/10D01F8/14D01F1/10D04H1/728A61L31/04A61L31/06A61L31/14D06M101/22D06M101/32
CPCD06M16/00D04H1/728D01F8/10D01F8/14D01F1/10A61L31/048A61L31/06A61L31/047A61L31/14D06M2101/22D06M2101/32A61L2400/12A61L2400/18C08L27/18C08L67/04C08L29/04
Inventor 黄建祥郑志国曹阳
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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