Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof

A polytetrafluoroethylene, surface modification technology, applied in the direction of fiber type, fiber treatment, biochemical fiber treatment, etc., can solve the problems of prosthesis failure, obstructive thrombus, and failure to achieve adhesion, so as to promote proliferation and promote Effect of endothelialization and accelerated adhesion

Pending Publication Date: 2022-03-01
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a surface-modified polytetrafluoroethylene fiber membrane and a preparation method thereof, the purpose of which is to solve

Method used

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  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof
  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof
  • Surface modified polytetrafluoroethylene fiber membrane and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0024] Example 1

[0025] The method of preparing the surface modified polytetrafluoroethylene fiber membrane provided in this example, the specific technical solution is as follows:

[0026] (1) Preparation of composite nanofibers:

[0027] A concentration of 5% PVA solution was added 20 μl and PLGA 2 g from 20 μl and PLGA 2G to a 50% PTFE emulsion, mixed, stirred at normal temperature for 24 h, resulting in a spinning liquid. The spinning fluid was transferred to 30 ml, and the high pressure electrostatic spinning was started in a syringe of the needle, and the spin voltage set 40 kV. The injection needle to the receiving drum was 30 cm, and the ambient temperature was 22 ° C, and the humidity was 45%. The spinning end of the spun ends from the drum from the end. The electrospinning fiber base film was subjected to a container contained in purified water, and then ultrasonic waves were washed 20 min, and then ethanol was rinsed 3 times, and finally the normal pressure of 50 ° C ...

Example Embodiment

[0031] Example 2

[0032] This embodiment provides a method of preparation of surface modified polytetrafluoroethylene fiber membranes, and specific technical solutions are as follows:

[0033] (1) Preparation of composite nanofibers:

[0034] The concentration of 10% of the PVA solution 10 mL, 5% boric acid solution 160 μL and PLGA 2G were added to the emulsion of 60%, 50 ml of PTFE, mixed, stirred at normal temperature for 24 h, resulting in spinning fluid. The spinning fluid was transferred to 30 ml, and the high-pressure electrostatic spinning was started in a syringe of the needle. The spinning voltage was set to 30 kV. The injection needle to the receiving drum was 20 cm, and the ambient temperature was 20 ° C, and the humidity was 40%. The spinning end of the spun ends from the drum from the end. The electrospinning fibrous base film was immersed in a container contained in purified water, and then ultrasonic waves were washed 10 min, and then ethanol was rinsed 3 times, an...

Example Embodiment

[0038] Example 3

[0039] This embodiment provides a method of preparation of surface modified polytetrafluoroethylene fiber membranes, and specific technical solutions are as follows:

[0040] (1) Preparation of composite nanofibers:

[0041] The concentration of 15% PVA solution 2 mL, 2% boric acid solution 200 μL and PLGA 2 g were added to 80%, 12.5 ml of PTFE emulsion, mixed, stirred at normal temperature for 24 h, resulting in spinning fluid. The spinning fluid was transferred to 30 ml, and the high pressure electrostatic spinning was started in a syringe of the needle, and the spin voltage set 40 kV. The injection needle to the receiving drum was 30 cm, and the ambient temperature was 22 ° C, and the humidity was 45%. The spinning end of the spun ends from the drum from the end. The electrospinning fibrous film was submerged in a container contained in purified water, and then ultrasonic waves were cleaned for 3 min, and then ethanol was rinsed 3 times, and finally the normal ...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a surface modified polytetrafluoroethylene fiber membrane and a preparation method thereof. According to the invention, a PTFE/PLGA composite nanofiber membrane is obtained by adopting a high-voltage electrostatic spinning method, and REDV is selectively fixed by modifying the nanofiber membrane, so that a biological material is functionalized. The surface modified and grafted fiber membrane can induce selective endothelial cells (ECs) to be effective, accelerate adhesion and promote endothelialization, meanwhile promotes proliferation of functional decellularized tissues used for blood contact application, and is a partially absorbable composite fiber membrane with very high application potential in the medical field of surgical hernia repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a surface-modified polytetrafluoroethylene fiber membrane and a preparation method thereof. Background technique [0002] Guided Tissue Regeneration (GTR) is a biological concept proposed by Nyman et al. in the early 1980s. Guided tissue regeneration membrane materials are the key to GTR technology. First of all, these materials should have good tissue compatibility and no cytotoxicity. , do not cause rejection, and secondly, its implantation in the body should be able to be absorbed by the tissue, and can be completely replaced by bone tissue, and the degradation rate of the membrane should match the tissue regeneration time. But the lack of a stable endothelial lining may affect the hemocompatibility of synthetic and biological alternatives. Typically, medical devices such as vascular grafts, stents, and glutaraldehyde-treated prosthetic heart valves h...

Claims

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Application Information

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IPC IPC(8): D06M16/00D01F8/10D01F8/14D01F1/10D04H1/728A61L31/04A61L31/06A61L31/14D06M101/22D06M101/32
CPCD06M16/00D04H1/728D01F8/10D01F8/14D01F1/10A61L31/048A61L31/06A61L31/047A61L31/14D06M2101/22D06M2101/32A61L2400/12A61L2400/18C08L27/18C08L67/04C08L29/04
Inventor 黄建祥郑志国曹阳
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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