Bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent

A technology of bioactive substances and extracellular matrix, which is applied in the field of biomimetic extracellular matrix bioactive substance-coated polyester mesh sheet scaffolds, can solve the problems of biocompatibility defects and the inability to fundamentally eliminate the influence of shear force , to achieve long-term function maintenance, high porosity and specific surface area, and promote adhesion

Active Publication Date: 2021-09-24
GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The reactor culture mode based on Cytopore microcarrier is stirring type. Although this porous structure can reduce the damage of shear force to cells to a certain extent, it cannot fundamentally eliminate the influence of shear force on cells.
Fibrous scaffolds such as FibraDisk carri

Method used

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  • Bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent
  • Bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent
  • Bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent

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[0027] The following detailed description of exemplary embodiments of the present application, the embodiments illustrated in the accompanying drawings, wherein same or similar reference numerals designate the same or similar elements or functionally similar or identical elements are provided with. By following with reference to the embodiments described are exemplary only for explaining the present application, and not to be construed as limiting the present disclosure.

[0028] The present application relates to a biologically active extracellular matrix material layer coating a polyester mesh sheet biomimetic scaffold, which is constructed mock cell growth in vivo microenvironment biomimetic cells by extracellular matrix components, it has good structural stability and mechanical properties, adapted to Large 3D cultured adherent cells, it is possible to achieve large-scale cell culture and promote the biological activity and function maintenance.

[0029] The biological extrace...

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Abstract

The invention provides a bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent, which comprises a surface carboxylated reticular lamellar layer and a bioactive substance coating layer covering the surface of the polyester reticular lamellar layer; the reticular lamellar layer is made of a polyester material; the bioactive substance coating layer is formed by coupling the reticular lamellar layer for multiple times; and a sealing layer is further arranged outside the bioactive substance coating layer. According to the invention, the advantages of certain mechanical property and plasticity of a synthetic polyester high polymer material are combined with good biocompatibility of a natural high polymer material, such that the stent in the invention not only has certain mechanical strength and good biocompatibility, but also provides a bionic culture environment for cell culture.

Description

technical field [0001] The present application relates to the technical field of tissue engineering, in particular to a bionic extracellular matrix bioactive substance-coated polyester mesh sheet scaffold. Background technique [0002] Physiological activities such as cell proliferation, differentiation, and metabolism are seriously affected by the regulation of the microenvironment. A bioreactor is a bioreactor for large-scale production of cells or for large-scale production of cells or for harvesting cell culture products. Among them, anchorage-dependent cells mainly add scaffold materials to the reactor to provide a cell growth surface, and realize high-density cell culture through the high specific surface area of ​​the material. [0003] At present, commonly used scaffold materials in bioreactors mainly include microcarriers Cytodex, Cytopore microcarriers, and fibrous scaffolds. Cytodex, a microcarrier attached to the cell surface, is a spherical two-dimensional cell...

Claims

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Application Information

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IPC IPC(8): C12N5/00
CPCC12N5/0062C12N2533/30C12N2533/70C12N2533/54C12N2533/90C12N2513/00
Inventor 高毅李阳张贵锋彭青
Owner GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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