Method for preparing darunavir

Abstract

The invention relates to the technical field of medicines and discloses a method for preparing darunavir. The method comprises the following step: preparing 20-30 parts of cobalt, 10-20 parts of triethylamine, 10-20 parts of ferrous oxide, 10-20 parts of zinc oxide, 3-5 parts of 1.2 equivalent of marina hydrogen methane, 20-30 parts of zinc, 50-80 parts of a ferric nitrite solution, 30-40 parts ofa metal base, 40-50 parts of alumina, 10-20 parts of silica, 3-5 parts of p-acetamide benzoyl sulfonyl chloride, 3-5 parts of a precipitant, 50-80 parts of an ethanol solution and 20-30 parts of nickel for later use. According the method for preparing the darunavir, 20-30 parts of cobalt, 10-20 parts of triethylamine, 10-20 parts of ferrous oxide, 10-20 parts of zinc oxide, 3-5 parts of 1.2 equivalent of marina hydrogen methane, 10-20 parts of silica, 3-5 parts of p-acetamide benzoyl sulfonyl chloride, 3-5 parts of the precipitant, 50-80 parts of the ethanol solution and 20-30 parts of nickelare adopted for later use, the reaction materials used in the method are low in price and low in reaction environment requirement, correspondingly, the preparation cost of the darunavir is greatly reduced, patients can afford the darunavir, and the darunavir can truly benefit the patients.

Description

technical field

[0001] The invention relates to the technical field of pharmaceutical production, in particular to a preparation method of darunavir. Background technique

[0002] Darunavir is a non-peptide HIV protease inhibitor, which works by blocking the formation of new, mature virion particles released from the surface of infected host cells and inhibiting viral protease. When this product is used for a long time Usually, it can reduce the HIV virus carrier in the blood, increase the count of CD4 cells, reduce the chance of AIDS infection, improve the quality of life, and prolong life. adults.

[0003] The preparation route of darunavir has been disclosed for a long time, but in the disclosed route method, the preparation efficiency of darunavir is low, the preparation cost is high, and the requirements for the preparation environment are also high, resulting in the price of darunavir finally prepared High, patients cannot afford such a high price, and the promotion ...