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Polyamino acid hydrogel dressing as well as preparation method and application thereof

A polyamino acid and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of limited application and popularization, difficulty in synthesis, and high cost, and achieve good application prospects, facilitate dressing changes, and simple preparation conditions

Active Publication Date: 2020-02-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the synthesis of such materials requires multi-step reactions, protection and deprotection operations, the synthesis difficulty and cost are very high, and the application and promotion are limited.

Method used

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  • Polyamino acid hydrogel dressing as well as preparation method and application thereof
  • Polyamino acid hydrogel dressing as well as preparation method and application thereof
  • Polyamino acid hydrogel dressing as well as preparation method and application thereof

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preparation example Construction

[0025] One aspect of the embodiments of the present invention provides a method for preparing a polyamino acid hydrogel dressing, comprising:

[0026] Reacting polyamino acids with cross-linking agents to prepare modified polyamino acids;

[0027] And, oxidizing the modified polyamino acid with an oxidant to obtain a polyamino acid hydrogel dressing.

[0028] In some embodiments, the method includes:

[0029] The polyamino acid is dissolved in a solvent to form a polyamino acid solution, and then a cross-linking agent is added to the polyamino acid solution, and reacted at 40-60° C. for 4-24 hours to prepare a modified polyamino acid.

[0030] In some embodiments, the molar ratio of the polyamino acid to the crosslinking agent is 100:1-5.

[0031] Further, the molar ratio of the polyamino acid to the crosslinking agent is 100:1-4.

[0032] Furthermore, the molar ratio of the polyamino acid to the crosslinking agent is 100:1, 100:2, 100:4.

[0033] Further, the polyamino ac...

Embodiment 1

[0053] Under argon protection, selenolactone (150mg) was added dropwise to polylysine aqueous solution (34g, 30wt%), obtained selenol-modified polylysine after reacting for 1 day under the condition of 50 ℃, polymer does not need Separation and purification are directly used in the next step, and the modification rate of polylysine is determined by NMR;

[0054] Polylysine hydrogel dressing (P1) is obtained by oxidizing 3wt% medical hydrogen peroxide. Add 3g of selenol-modified polylysine and 7mL of water into a 50mL beaker. After fully dissolving, place it open or add it with selenolactone 3wt% medical hydrogen peroxide in an equimolar amount, and the formation process of the gel is monitored by a rheological test or an inverted bottle experiment.

Embodiment 2

[0056] In this embodiment, according to the molar ratio [polylysine] 0 :[Selenolactone] 0 =100:2, make polylysine and selenolactone react, other reaction steps and reaction conditions are identical with embodiment 1, obtain polylysine acid hydrogel dressing (P2), wherein the molar percentage of selenium 2% (m / m).

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Abstract

The invention discloses a polyamino acid hydrogel dressing as well as a preparation method and an application thereof. The preparation method of the polyamino acid hydrogel dressing comprises the following steps: reacting polyamino acid with a cross-linking agent at 25-80 DEG C for 4-24 hours to obtain modified polyamino acid; and carrying out an oxidation reaction on the modified polyamino acid and an oxidant at 25-80 DEG C for 4-24 hours to obtain the polyamino acid hydrogel dressing. Compared with the prior art, the raw material of the polyamino acid hydrogel dressing provided by the invention is commercialized polyamino acid with an antibacterial effect; the functional groups of a cross-linking agent have multiple responsibilities, controllable and on-demand degradation of the hydrogeldressing is achieved by controlling different stimulation conditions, the replacement of the wound dressing is more convenient, secondary damage in the wound dressing process is reduced, and the hydrogel dressing has good medical application prospects.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a polyamino acid hydrogel dressing and a preparation method and application thereof. Background technique [0002] Skin or tissue damage can be caused by collisions, burns, surgery and many other reasons. Wound healing is a long process. The traditional gauze wound treatment method requires frequent dressing changes, resulting in long hospital stays and high medical expenses, which not only affect the daily life and work of patients, but also adversely affect the average length of stay in the hospital. influences. Wound healing is one of the most important basic problems in medicine, and its research has drawn more and more attention from people. [0003] An ideal dressing should have the following conditions: (1) be able to stop bleeding within a few hours; (2) have a certain degree of adhesion to the tissue; (3) be easy to use; Dissolution can be easily...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L77/02
CPCA61L26/0019A61L26/0061A61L26/008A61L26/009C08J3/075C08J3/24C08J2377/02C08L77/02
Inventor 潘向强陆伟红安晓伟朱健
Owner SUZHOU UNIV
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