Unlock instant, AI-driven research and patent intelligence for your innovation.

Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof

A composite material and implant technology, which is applied in the field of functional bone implant manufacturing, can solve the problems of weak biological activity and weak bone tissue binding ability, and achieve the effect of enhancing biological activity, meeting pathological needs, and enhancing bonding strength

Active Publication Date: 2020-02-11
HUAIYIN INSTITUTE OF TECHNOLOGY
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: The technical problem to be solved by the present invention is to provide a gradient titanium-magnesium composite material implant for osteoconductive growth, based on the selective laser melting 3D printing technology, forming a porous titanium alloy implant, and supplemented by hydrostatic extrusion The porous material is fully filled with degradable magnesium alloy and osteoinductive hydroxyapatite to obtain a gradient titanium-magnesium composite material implant, so as to solve the problem of weak biological activity of artificial titanium alloy implants in the prior art and bone-inductive problems. Insufficient organizational integration ability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof
  • Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof
  • Gradient titanium-magnesium composite material implant for inducing bone growth and forming method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Spherical medical titanium alloy powder is formed into titanium alloy porous structure implants by selective laser melting technology;

[0044](2) Under the protection of high-purity argon, mix the Mg-Zn alloy and nano-hydroxyapatite powder with a mass ratio of 10:1 in a high-energy ball milling process with a rotation speed of 40 rpm to obtain a uniformly mixed composite material powder;

[0045] (3) Wrap the titanium alloy porous implant in step (1) with the mixed powder in step (2), put it into the ceramic extrusion cylinder of the hydrostatic extrusion testing machine, and then vacuumize to 5×10 -3 Pa, heat the extrusion cylinder at 650°C until the Mg-Zn alloy powder is melted and keep it warm for 10 minutes, and apply a 0.05T magnetic field to the outer ring of the extrusion cylinder to promote the uniform composition of the Mg-Zn alloy melt in the cylinder;

[0046] (4) cyclically apply a compressive stress of 0.5 MPa on both sides of the extrusion cylinder, a...

Embodiment 2

[0049] (1) Spherical medical titanium alloy powder is formed into titanium alloy porous structure implants by selective laser melting technology;

[0050] (2) Under the protection of high-purity argon, the Mg-Ca alloy with a mass ratio of 30:1 and nano-hydroxyapatite powder are mixed in a high-energy ball milling process with a rotation speed of 80 rpm to obtain a uniformly mixed composite material powder;

[0051] (3) Wrap the titanium alloy porous implant in step (1) with the mixed powder in step (2), put it into the ceramic extrusion cylinder of the hydrostatic extrusion testing machine, and then vacuumize to 3×10 -3 Pa, heat the extrusion cylinder at 700°C until the Mg-Ca alloy powder melts and keep it warm for 20 minutes, and apply a 0.1T magnetic field to the outer ring of the extrusion cylinder to promote the uniform composition of the Mg-Ca alloy melt in the cylinder;

[0052] (4) cyclically apply a compressive stress of 3 MPa on both sides of the extrusion cylinder, s...

Embodiment 3

[0056] (1) Spherical medical titanium alloy powder adopts selective laser melting technology to form a titanium alloy porous structure implant, the titanium alloy powder is Ti-Nb alloy powder, and the mass fraction of Ti in the Ti-Nb alloy powder is 65%. , the mass fraction of Nb is 35%;

[0057] (2) Under the protection of high-purity argon, the Mg-Zr alloy with a mass ratio of 50:1 and nano-hydroxyapatite powder are mixed in a high-energy ball milling process with a rotation speed of 100 rpm to obtain a uniformly mixed composite material powder;

[0058] (3) Wrap the titanium alloy porous implant in step (1) with the mixed powder in step (2), put it into the ceramic extrusion cylinder of the hydrostatic extrusion testing machine, and then evacuate to 1×10 -3 Pa, heat the extrusion cylinder at 750°C until the Mg-Zr alloy powder is melted and keep it warm for 20 minutes, and apply a 0.2T magnetic field to the outer ring of the extrusion cylinder to promote the uniform composit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a gradient titanium-magnesium composite material implant for inducing bone growth and a forming method thereof, and belongs to the field of functional bone implant manufacturing. A titanium alloy porous structure implant hole formed by selective laser melting is extruded and filled with a slow-release magnesium alloy and bone-induced growth nano-hydroxyapatite composite material to form the gradient titanium-magnesium composite material implant. The gradient titanium-magnesium composite material implant is implanted under the combined action of slow release of the magnesium alloy and induction of hydroxyapatite, can easily induce controllable growth of bones, and has good market prospects and application value.

Description

technical field [0001] The invention relates to a gradient titanium-magnesium composite material implant for inducing bone growth and a forming method thereof, belonging to the field of functional bone implant manufacture. Background technique [0002] Titanium alloy is widely used as one of the preferred materials for clinical interventional devices due to its excellent comprehensive properties such as high mechanical properties, good biocompatibility, and good corrosion resistance in physiological environments. Personalized treatment is a medical feature of the 21st century. Due to differences in age and gender of patients, and most artificial bone implants have complex structures, common molding methods such as powder metallurgy and casting cannot meet the requirements of manufacturing titanium alloy artificial bone implants. Require. The 3D printing technology based on the principle of "layer-by-layer accumulation" has unique flexible manufacturing characteristics, and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B22F3/11B22F3/20B33Y10/00B33Y80/00A61L27/04A61L27/06A61L27/12A61L27/50A61L27/56A61L27/58
CPCB22F3/11B22F3/20B33Y10/00B33Y80/00A61L27/06A61L27/047A61L27/12A61L27/58A61L27/56A61L27/50B22F2003/206B22F2003/208A61L2430/02
Inventor 夏木建林岳宾王华玲姜海林刘爱辉李年莲丁红燕
Owner HUAIYIN INSTITUTE OF TECHNOLOGY