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HAp-CSA-SF composite gel material, and preparation method and application thereof

A technology of composite gel and composite gel layer, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve problems such as low support performance, poor toughness, weak cartilage and bone integration, etc., and achieve good effect and high toughness Effect

Active Publication Date: 2020-02-14
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing SF scaffold materials have poor toughness and low support performance
In addition, in the current repair process, the transition between cartilage and bone tissue is often ignored, resulting in an unstable bond between cartilage and bone after repair.

Method used

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  • HAp-CSA-SF composite gel material, and preparation method and application thereof
  • HAp-CSA-SF composite gel material, and preparation method and application thereof
  • HAp-CSA-SF composite gel material, and preparation method and application thereof

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preparation example Construction

[0045] In one or more specific embodiments of the present invention, there is provided a preparation method of the above-mentioned HAp-CSA-SF composite gel material.

[0046] Preparation of HAp: mix oleic acid and ethanol, add calcium salt solution, then add lye solution, then add sodium hydrogen phosphate solution, stir, and react at high temperature.

[0047] Preparation of CSA-SF complex acid solution: A silk fibroin formic acid solution was prepared, and chondroitin sulfate was added to the silk fibroin formic acid solution.

[0048] In one or more specific embodiments of the present invention, the preparation method further includes placing the CSA-SF composite mixed acid solution into a mold bearing HAp, and the HAp-CSA-SF composite gel is obtained after the acid solution is volatilized and cooled Material.

[0049] In one or more specific embodiments of the present invention, the preparation method further includes immersing the HAp-CSA-SF composite gel material prepar...

Embodiment

[0065] Experimental materials and methods:

[0066] (1) Preparation and characterization of HAp-CSA-SF high toughness gel material

[0067] 1. Degumming will 2.55g anhydrous NaCO 3 Add to boiled deionized water, wait for complete dissolution, pour 3g of the chopped silkworm shell into it, stir and heat for 30min, take out the degummed silk, wash it with deionized water for 2 to 3 times, soak it overnight, take it out, room temperature Let dry.

[0068] 2. Preparation of HAp short nanowires

[0069] First mix 8ml oleic acid and 10ml absolute ethanol, then add 147mg CaCl 2 ·2H 2 Aqueous O (6ml) followed by 0.5g aqueous NaOH (8ml) followed by 156mg NaH 2 PO 4 ·2H 2 Aqueous O solution (4 ml), stirred for 10 min. Finally, the reaction was carried out in an oven at 180 °C for 12 h. After washing with absolute ethanol, HAp short nanowires were obtained.

[0070] 3. Dissolve Weigh 0.2~1g anhydrous calcium chloride, dissolve it in 10~15ml 88% formic acid, add 1~2g silk in the...

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Abstract

The invention provides a HAp-CSA-SF composite gel material. The HAp-CSA-SF composite gel material comprises a chondroitin-sulfate silk-fibroin composite gel layer, as well as a hydroxyapatite-enrichedlayer arranged on at least one end face of the chondroitin-sulfate silk-fibroin composite gel layer; the hydroxyapatite-enriched layer is capable of repairing damaged inner-layer bone tissue, as wellas enhancing bonding strength between cartilages and adjacent bones, thereby ensuring that a repaired cartilage can function normally; and the chondroitin-sulfate silk-fibroin composite gel layer isintegrated gel made from chondroitin sulfate and silk fibroin. Moreover, along with degradation of the silk fibroin, the chondroitin sulfate can be synchronously released so as to further promote regeneration of cartilages, thereby realizing repair on the cartilages. By adopting a multiphase layered design, the HAp-CSA-SF composite gel material is capable of realizing rapid cartilage repair, as well as synchronously enhancing bonding strength between repaired cartilages and adjacent bones

Description

technical field [0001] The invention belongs to the technical field of cartilage tissue repair, in particular to a HAp-CSA-SF composite gel material and a preparation method and application thereof. Background technique [0002] The information disclosed in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] Cartilage tissue engineering is one of the important directions of tissue engineering. Cartilage plays an important role in the human body, such as load-bearing, force transmission and buffering. The cartilage in the joints is the basis for maintaining the normal movement of the human body. However, cartilage wear and cartilage damage caused by external forces occur frequently, and cause problems such as inflammation, pain, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/40A61L27/12A61L27/52A61L27/54A61L27/58
CPCA61L27/12A61L27/26A61L27/52A61L27/54A61L27/58A61L2300/232A61L2300/412A61L2300/604A61L2430/06C08L89/00C08L5/08
Inventor 葛少华马保金商玲玲刘宏
Owner SHANDONG UNIV
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