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Polymer-collagen composite membrane and production method thereof

A collagen and manufacturing method technology, applied in chemical instruments and methods, membrane technology, pharmaceutical formulations, etc., can solve the problems of long time consumption, low power, poor processing efficiency, etc., to increase the grafting rate, shorten the process time, The effect of improving hydrophilicity

Inactive Publication Date: 2020-02-14
台钜生技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods use low power and process a large area of ​​the substrate surface at the same time, which is time-consuming and inefficient

Method used

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  • Polymer-collagen composite membrane and production method thereof
  • Polymer-collagen composite membrane and production method thereof
  • Polymer-collagen composite membrane and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] In Example 1, a circular polyurethane (PU) film (Pellethane 2363; manufactured by Upjohn Corporation) having a diameter of 15 mm was provided as a polymer substrate. With the power of 600W, the moving speed of 300mm / sec, the treatment height of 10mm, carry out plasma treatment to PU film and reach 0.1 minute, to form treatment film (using such as Figure 2B continuous plasma treatment as shown). Afterwards, 200 μl of a collagen solution with a concentration of 1 mg / ml was coated on the treated membrane and reacted for 1 hour to obtain the polymer-collagen composite membrane of Example 1 grafted by plasma treatment. The weight average molecular weight of the collagen in the collagen solution is 30,000. Concrete process parameter and evaluation result about embodiment 1, see table 1, Figure 3A and Figure 3B shown.

Embodiment 2 to 8 and comparative example 1 to 2

[0067] Examples 2 to 8 and Comparative Examples 1 to 2 are carried out using the same method as in Example 1. The difference is that the process parameters of plasma treatment or collagen grafting were changed in Examples 2 to 8 and Comparative Examples 1 to 2. also, Figure 3A and Figure 3B The PU1 is carried out in the same manner as in Example 1, Figure 4A and Figure 4B The PU2 is performed in the same manner as in Example 5, but Figure 3A , Figure 3B , Figure 4A and Figure 4B PU1 and PU2 were not plasma treated. Concrete process parameter and evaluation result about embodiment 2 to 8 and comparative example 1 to 2, see table 1, Figure 3A , Figure 3B , Figure 4A and Figure 4B shown.

[0068] Table 1

[0069]

[0070] PU1 Pellethane 2363 (manufactured by Upjohn)

[0071] PU2 Polyesterurethane 6608 (manufactured by Dadong Plastic Chemical Co., Ltd.)

[0072] Evaluation method

[0073] 1. Hydrophilic angle

[0074] The hydrophilic angle of the em...

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Abstract

The invention provides a polymer-collagen composite membrane and a production method thereof. In the method, the surface of a polymer substrate is treated with plasma, and collagen is grafted to the treated surface, so that the polymer-collagen composite membrane is obtained. According to the invention, the composite membrane has good hydrophilicity and good biocompatibility.

Description

technical field [0001] The present invention relates to a composite membrane and its manufacturing method, and in particular to a polymer-collagen composite membrane and its manufacturing method. The manufacturing method involves treating the surface of the polymer base material with plasma, and grafting collagen on the treated base material surface, so as to obtain a polymer-collagen composite film with good hydrophilicity. Background technique [0002] Polymer substrates are widely used in the fields of cosmetics and medicine, such as dressings, support layers of dressings, and mask substrates. In order to further increase the applicability or biocompatibility of the polymer substrate in the above fields, the polymer substrate is often modified by various modification methods. [0003] For example: Collagen is often used in various biomedical materials because of its functions of repairing tissues and maintaining moisture. However, due to the insufficient support and mec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/78B01D71/70B01D71/58B01D71/26B01D71/08B01D69/12B01D67/00
CPCB01D67/0002B01D69/12B01D71/08B01D71/26B01D71/58B01D71/70B01D71/78A61L15/22A61L15/325A61L27/14A61L27/34A61L27/60A61L2400/18A61L2420/02B05D3/144B05D7/04C08L89/06
Inventor 陈柏翰蔡雅雲陈东亮陈一铭
Owner 台钜生技股份有限公司