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Composite fluorescent particle protected by superhydrophobic shell and preparation method thereof

A composite fluorescence, super-hydrophobic technology, applied in chemical instruments and methods, compounds containing Group 3/13 elements of the periodic table, Group 3/13 organic compounds without C-metal bonds, etc. Stability, disappearance, affecting the spatial structure of fluorescent molecules inside the particle, etc., to increase the fluorescence stability and maintain the stability.

Active Publication Date: 2021-01-08
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

First, because its porous structure is in an ionic and aqueous environment, it cannot limit the penetration of ions and water into the MOF to quench the fluorescence of fluorescent dyes; second, under the strong coordination of foreign anions to metal ions in MOF materials , the topological structure of MOF materials is prone to amorphization, which affects the spatial structure of fluorescent molecules inside the particle, causing its fluorescence intensity to weaken or even disappear.
[0005] It can be seen that there are still problems in the existing preparation technology: due to the strong coordination of various ions in the environment to be tested, the complex fluorescent particles based on MOF materials as carriers often lead to the coordination of rare earth complexes due to unstable structures. The structure changes, so that the fluorescence stability cannot be guaranteed, and it is difficult to apply to the field of fluorescent labeling

Method used

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  • Composite fluorescent particle protected by superhydrophobic shell and preparation method thereof
  • Composite fluorescent particle protected by superhydrophobic shell and preparation method thereof
  • Composite fluorescent particle protected by superhydrophobic shell and preparation method thereof

Examples

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preparation example Construction

[0033] The invention provides a method for preparing Tb complex@ZIF-8@F-ZI F-90 composite fluorescent particles with a super-hydrophobic shell, comprising the following steps:

[0034] Step 1, first, measure 4mL 2-methylimidazole (HMIM) methanol solution and 2-4 mg Tb complex into a 10mL single-necked flask; take 4mL zinc nitrate hexahydrate (Zn(NO 3 ) 2 ·6H 2 O) methanol solution and 0.1mL cetyltrimethylammonium bromide (CTAB) methanol solution are configured to obtain a zinc nitrate solution; then, under stirring, the zinc nitrate solution is quickly added to a 10mL single-necked flask, and Reaction 24h;

[0035] Among them, the concentration of 2-methylimidazole methanol solution is 51~69mg·mL -1 , the concentration of methanol solution of zinc nitrate hexahydrate is 18~24mg·mL -1, cetyltrimethylammonium bromide methanol solution is 73~97mg·mL -1 .

[0036] In step 2, the product in step 1 is centrifuged at 9000-11000 rpm for 5-10 min to collect the precipitate, and t...

Embodiment 1

[0042] Such as figure 1 As shown, the Tb complex@ZIF-8@F-ZIF-90 composite fluorescent particle synthesis process schematic diagram provided in the embodiment of the present invention, the Tb complex@ZIF-8@F-ZIF-90 composite fluorescent particle provided in this embodiment The particle synthesis process includes the following steps:

[0043] Step 1. First, weigh 200-220 mg of 2-methylimidazole (HMIM) and 2-4 mg of rare earth complex terbium into 4-6 mL of methanol solution and add it to a 10 mL single-necked flask; 71-76 mg of zinc nitrate hexahydrate (Zn (NO 3 ) 2 ·6H 2 0) and 7~9mg cetyltrimethylammonium bromide (CTAB) are dissolved in 4~6mL methanol solution, obtain zinc nitrate solution; React at 37°C for 24 hours; finally, centrifuge the reaction solution at 9000-11000 rpm for 5-10 minutes to collect the product, and wash the product twice with methanol. The final product was suspended in methanol to obtain Tb complex@ZIF-8 fluorescent nanoparticles.

[0044] Step 2,...

Embodiment 2

[0055] The synthesis process of Tb complex@ZIF-8@F-ZIF-90 composite fluorescent particles provided in this example includes the following steps:

[0056] Step 1. First, weigh 200-220 mg of 2-methylimidazole and 2-4 mg of rare earth complex terbium and add it to 4-6 mL of methanol solution and add it to a 10 mL single-necked flask; 71-76 mg of zinc nitrate hexahydrate and 7-9 mg of Hexaalkyltrimethylammonium bromide was dissolved in 4-6mL of methanol solution to obtain zinc nitrate solution; then, under stirring, the zinc nitrate solution was quickly added to the single-necked flask, and reacted at 37°C for 24 hours; finally, the reaction solution The product was collected by centrifugation at 9000-11000 rpm for 5-10 min, and the product was further washed twice with methanol. The final product was suspended in methanol to obtain Tb complex@ZIF-8 fluorescent nanoparticles.

[0057]Step 2, first, weigh 10-15 mg of the Tb complex @ZIF-8 fluorescent nanoparticles obtained in the ...

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Abstract

The invention discloses composite fluorescent particles with a superhydrophobic protective shell layer and a preparation method of the composite fluorescent particles. The method comprises the following steps: by using zinc nitrate hexahydrate and 2-methylimidazole as raw materials, introducing a rare earth complex as a fluorescent molecule to synthesize zeolite imidazate skeleton material-8 coated rare earth complex core fluorescent particles; in a mixed solvent of ethanol and water, by using zinc hexahydrate and imidazole-2-carboxaldehyde as raw materials, growing the hydrophobic zeolite imidazate skeleton material-90 shell layer in situ on the surfaces of the core fluorescent particles; and finally, performing fluorination modification on the surfaces of the core-shell structural composite fluorescent particles to obtain the composite fluorescent particles with the superhydrophobic protective shell layer capable of maintaining fluorescence stability. The composite fluorescent particles have good dispersibility and fluorescence stability, the average particle size is 60+ / -5 nm, the fluorescence lifetime can reach 1.8 ms, the quantum yield can reach 19.1%, and the composite fluorescent particles have huge application prospects in the fields of biological detection and fluorescence imaging.

Description

technical field [0001] The invention belongs to the technical field of synthesis of luminescent nanomaterials, and in particular relates to a composite fluorescent particle protected by a superhydrophobic shell and a preparation method thereof. Background technique [0002] With the in-depth research on the pathological process of tumors and its subsidiary features, many characteristic markers such as specific proteins and small peptide molecules have been discovered by researchers. To a certain extent, these characteristic markers can be used as a detection signal source to reflect A cell or tissue in the body that may become cancerous. Due to the low cure rate and high cost of current cancer treatment, the development of early tumor diagnosis technology to curb the occurrence of tumor has become one of the hot research issues today. [0003] At present, the simple, efficient, accurate and reliable suspension array diagnostic technology is one of the latest technologies fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/06C07F5/00B82Y30/00
CPCB82Y30/00C07F5/003C09K11/025C09K11/06C09K2211/182
Inventor 张吉喜莫东孙凯瑶丁涛
Owner CHONGQING UNIV
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