A kind of wolfberry leaf active ingredient capsule and preparation method thereof
A kind of technology of active ingredient and wolfberry leaf, which is applied in the field of preparation of traditional Chinese medicine preparations
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Embodiment 1
[0028] Embodiment 1: the screening of auxiliary material type
[0029] Select carboxymethylcellulose sodium (CMC-Na), soluble starch, lactose, micropowder silica gel, dextrin, magnesium stearate 6 kinds of commonly used excipients, design 7 different prescriptions according to Table 1, and divide the main drug and auxiliary materials according to 1: 5 proportions are mixed evenly, and the best excipients are screened based on the angle of repose and moisture absorption rate.
[0030] Table 1 Composition design of active ingredient capsules of Lycium barbarum leaves (g)
[0031]
[0032] The moisture absorption rate measurement method is as follows:
[0033] Place the glass desiccator filled with NaCl supersaturated solution at the bottom in a constant temperature incubator at 25°C for 24 hours. At this time, the humidity in the desiccator is 75%, and spread the medicinal powder in a flat weighing bottle dried to constant weight. , about 2mm in thickness, accurately weighe...
Embodiment 2
[0042] Embodiment 2: Screening of wetting agent ethanol concentration
[0043] Screen 10%, 30%, 50%, 70%, 90%, different concentrations of ethanol as the best wetting agent, the bulk drug and the auxiliary materials screened in Example 1 are placed in a 40°C oven after passing through an 80 mesh sieve respectively Remove the water for 2 hours, then weigh 1g of raw material medicine according to the ratio of raw material medicine: starch: lactose: micropowder silica gel = 1:2:2:1, and add 10%, 30%, 50% %, 70%, 90% ethanol with different concentrations to prepare the soft material (the soft material is in agglomerate state, and it will disperse when touched), and then pass through a 20-mesh sieve for granulation, and place the granulated sample in an oven at 40°C for 30 minutes. take out. The prepared granules are weighed, first passed through a 80-mesh sieve, and then passed through a 10-mesh sieve, and the particles that can pass through the 80-mesh sieve but cannot pass thro...
Embodiment 3
[0049] Embodiment 3: the dosage ratio screening of raw material and auxiliary material
[0050] Table 3 Prescription Design of Raw Material Consumption Ratio
[0051]
[0052] According to Table 3, the ratio of raw material to auxiliary material is 1:1, 1:2, 1:3, 1:4, 1:5, the ratio of auxiliary material to auxiliary material is lactose:starch=1:1, and the wetting agent uses 70% concentration Ethanol was designed as the above four prescriptions, and the granulation steps were carried out according to Example 2. After granulation, the granulation rate, angle of repose, bulk density, tap density, Hausner ratio and Carr index were measured respectively. Bulk density and tap density are measured as follows:
[0053] Using the graduated cylinder method, accurately weigh 5 g of the granules prepared by the above prescription, put the sample into a 10 ml graduated cylinder, measure and record the volume of the sample, and measure 5 times in total. Hold the graduated cylinder and...
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