Doxycycline hydrochloride tablets for pets and preparation method thereof

Abstract

The invention discloses doxycycline hydrochloride tablets for pets and a preparation method of the doxycycline hydrochloride tablets. The doxycycline hydrochloride tablets are characterized by being prepared from the following raw materials in parts by weight: 10-50 parts of doxycycline hydrochloride, 100-150 parts of microcrystalline cellulose, 20-30 parts of sodium carboxymethyl starch, 1-3 parts of magnesium stearate and 10-15 parts of a phagostimulant. Wherein the phagostimulant is one of a chicken liver extract and a beef-flavored milk cake. The preparation method comprises the followingsteps: uniformly mixing doxycycline hydrochloride, microcrystalline cellulose, sodium carboxymethyl starch and the phagostimulant, granulating by a dry method, mixing the prepared granules with magnesium stearate for 3 minutes, and tabletting to obtain the doxycycline hydrochloride tablets.

Description

Background technique [0001] Doxycycline hydrochloride, also known as doxycycline or deoxyoxytetracycline, is a broad-spectrum antibacterial agent, which can be used clinically for Rickettsia, mycoplasma, chlamydia, spirochetes, gram-positive bacteria and gram-negative bacteria, etc. Treatment and prevention of microbial infections. Doxycycline hydrochloride is mainly used in pets to treat pet colds, coughs, bronchitis, etc. Currently, the dosage forms used for pet treatment in the market are mainly tablets. The traditional process adopts the wet granulation process, which is complex and must be dried at 50-60°C for 2-3 hours after being made into a soft material. However, doxycycline hydrochloride, like other tetracycline drugs, is prone to hydrolysis when exposed to heat, resulting in related The substance rises and affects the quality of the product. In addition, because it is a medicine for pets, a certain proportion of food attractant is added to the prescription. If the...

AI Technical Summary

Problems solved by technology

The traditional process adopts the wet granulation process, which is complex and must be dried at 50-60°C for 2-3 hours after being made into a soft material. However, doxycycline hydrochloride, like other tetracycline drugs, is prone to hydrolysis when exposed to heat, resulting in related Elevated substances, affecting the quality of the product

In addition, because it is a medicine for pets, a certain proportion of food attractant is added to the prescription. If the traditional wet granulation process is followed, the taste of the food attractant will become lighter during the drying process, and the palatability will deteriorate, reducing the pet's appetite. feeding initiative

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