A kind of eucommia tonifying waist mixture and its application

A technology of mixture and solvent, applied in the field of composition medicine, to achieve the effect of repairing damaged ovaries and improving endocrine disorders

A technology of mixture and solvent, applied in the field of composition medicine, to achieve the effect of repairing damaged ovaries and improving endocrine disorders

CN110859890BActive Publication Date: 2022-02-08HUBEI WEISHI BIO PHARMA
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  • A kind of eucommia tonifying waist mixture and its application
  • A kind of eucommia tonifying waist mixture and its application

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preparation example Construction

[0016] 1. Preparation of Pig Kidney Extract

[0017] The present invention provides a kind of preparation method of pig kidney extract, comprising steps:

[0018] Extraction: Take the pig kidney cortex, homogenize it in the first solution at 2-8°C, take the supernatant after solid-liquid separation, precipitate the supernatant with solvent, dissolve the precipitate in the second solution, add solvent to extract, centrifuge, absorb The centrifuged aqueous layer was concentrated by ultrafiltration in the second solution to obtain the first concentrated solution.

[0019] Specifically, the first solution is selected from sodium chloride solution (H1), PBS solution (H2), disodium hydrogen phosphate-sodium chloride solution (H3), potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer solution (H4) and One of potassium dihydrogen phosphate-sodium hydroxide buffer (H5). The second solution was added sodium deoxycholate (H6) to the first solution. The solvent is one o...

Embodiment 1

[0032] Embodiment 1: 150 parts of pig kidney extract of embodiment 3, 200 parts of Eucommia ulmoides, 120 parts of Rehmannia glutinosa, 85 parts of Codonopsis pilosula, 200 parts of angelica, 50 parts of medlar, 120 parts of psoralen, 80 parts of Achyranthes bidentata, 50 parts of dodder , 40 parts of Ligustrum lucidum, wherein the Chinese medicinal materials are obtained by boiling the liquid at high temperature with water for 2 hours according to the above ratio, and the solid matter obtained after freeze-drying is formulated with the extract of pig kidney to make Eucommia tonic mixture, which is an oral solution.

Embodiment 2

[0033] Embodiment two: 100 parts of pig kidney extract of embodiment 3, 200 parts of Eucommia ulmoides, 120 parts of rehmannia glutinosa, 85 parts of Codonopsis pilosula, 200 parts of angelica, 50 parts of medlar, 120 parts of psoralen, 80 parts of Achyranthes bidentata, 50 parts of dodder , 40 parts of Ligustrum lucidum, wherein the Chinese medicinal materials are obtained by boiling the liquid at high temperature with water for 2 hours according to the above ratio, and the solid matter obtained after freeze-drying is formulated with the extract of pig kidney to make Eucommia tonic mixture, which is an oral solution.

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Abstract

The invention discloses a eucommia tonic mixture and application thereof. The pig kidney extract used in preparing the eucommia tonic mixture is prepared through four steps of extraction, salting-out, chromatography and post-treatment. The eucommia tonic mixture is prepared from the following raw materials in parts by mass: 80-150 parts of pig kidney extract obtained by freeze-drying pig kidney extract, 200-205 parts of Eucommia ulmoides, 120-125 parts of Rehmannia glutinosa, and 80-85 parts of Codonopsis pilosula , 200 parts of angelica, 50 parts of medlar, 120-125 parts of psoralen, 80-85 parts of Achyranthes bidentata, 50 parts of dodder seed, 40 parts of privet fruit. In the present invention, by controlling the process parameters of the preparation method, the yield of the extracted pig kidney extract is as high as 763.5 mg / kg; rat experiments show that the Eucommia Bu Yao mixture prepared from the pig kidney extract has application prospects as a drug for treating premature ovarian failure .

Description

technical field [0001] The invention relates to the technical field of composition medicaments, in particular to a eucommia tonic mixture and its application. Background technique [0002] Pig kidney, commonly known as pig loin, has the functions of invigorating the kidney, curing deficiency, promoting body fluid and quenching thirst, and can be used for symptoms such as kidney deficiency, edema, and deafness. Pig kidney contains zinc, iron, copper, phosphorus, vitamin A, B vitamins, vitamin C, protein, fat, carbohydrates and other nutrients. "Materia Medica" pickled this product with pepper and salt to remove the fishy water, added 10g of Eucommia powder, wrapped it in lotus leaves and simmered it, and used it to treat kidney deficiency and low back pain. The Eucommia Buyao mixture prepared from this mainly contains Eucommia ulmoides, Rehmannia glutinosa, Codonopsis pilosula, Angelica, Lycium barbarum, Psoralen, Achyranthes bidentata, Cuscuta seed, pork kidney, shiitake mu...

Claims

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Application Information

Patent Timeline
08 Feb 2022
Publication
CN110859890B
IPC
A61K36/815; A61P15/08; A61K35/22
CPC
A61K35/22; A61K36/46; A61K36/804; A61K36/344; A61K36/232; A61K36/815; A61K36/487; A61K36/21
Inventors
罗先隽