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Pharmaceutical composition containing amino acid nutrient and conventional ineffective compound and application of pharmaceutical composition

An amino acid and composition technology, which is applied in drug combinations, medical preparations containing active ingredients, anhydride/acid/halide active ingredients, etc., to achieve the effects of low local irritation, effective treatment, and high efficacy of local lesions

Inactive Publication Date: 2020-03-10
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is still a need to develop new drugs for the treatment of local disease such as solid tumors, especially local drugs, to meet various clinical needs that cannot be met by existing technologies

Method used

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  • Pharmaceutical composition containing amino acid nutrient and conventional ineffective compound and application of pharmaceutical composition
  • Pharmaceutical composition containing amino acid nutrient and conventional ineffective compound and application of pharmaceutical composition
  • Pharmaceutical composition containing amino acid nutrient and conventional ineffective compound and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0089] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing a liquid medicine containing the topical active ingredient, a liquid medium and other substances optionally present. The liquid medicament may be a solution (eg, in a hydrophilic vehicle, preferably an aqueous solution), a suspension, or an emulsion containing the topically active ingredient. When the liquid drug is a suspension, the dispersion medium therein can be any suitable one known to those skilled in the art, such as micro-materials or nano-materials. When the liquid drug is an emulsion, the dispersion medium therein can be any suitable one known to those skilled in the art, such as vegetable oil, synthetic oil or semi-synthetic oil that can be used for injection. Wherein said vegetable oil may be, for example, cottonseed oil, almond oil, olive oil, castor oil, sesame oil, soybean oil an...

Embodiment 1

[0181] Embodiment 1: the preparation of composition

[0182] According to the above preparation method of the composition of the present invention, many different compositions of the present invention can be prepared. The compositions of some compositions of the present invention prepared in this example are listed in Table 2.

[0183] Table 2

[0184]

[0185]

[0186] Several examples of preparation tests of the compositions of the present invention are listed below.

[0187] 1. Preparation of liquid injection (1)

[0188] Measure amino acid nutrients (such as 10g glutathione), conventional invalid compounds (such as 30g glucose), optional other components and dilute to total volume (such as 100ml) according to the required concentration (as described in Table 2). ) liquid carrier (such as water for injection), and they are slowly mixed evenly, and after sterilizing and filtering, they are subpackaged into required quantities (such as 10ml / bottle) and stored for late...

Embodiment 2

[0201] Embodiment 2: Composition synergistic technical scheme is preferred

[0202] 1. Synergistic pharmacological optimization

[0203] In this research experiment, the successfully modeled experimental animals (bearing S180 mice, with an average tumor volume of 121mm 3 ) were randomly divided into 2 negative control groups and 22 research groups. The negative control was normal saline, and the 11 research drugs were shown in the table below, and they were injected intraperitoneally and intratumorally respectively. The medicines are all aqueous solutions, which are prepared according to the preparation method of Example 1. Medication once every 3 days, a total of 3 times, the injection volume ≤ 120μl / mouse. Five days after the end of the medication, the animals were euthanized, the tumor weight was measured after dissection, and the tumor inhibition rate was calculated from the negative control group of each medication method. The results are shown in Table 3.

[0204] ta...

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PUM

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Abstract

The invention discloses an application of an amino acid nutrient as a topical active ingredient in preparation of a topical pharmaceutical composition for treating topical lesion diseases, a topical pharmaceutical composition, which contains the amino acid nutrient topical active ingredient and conventional ineffective compound, for treating topical lesion diseases, and a device comprising the composition.

Description

technical field [0001] The disclosure of the present application relates to the application of amino acid nutrients as local active ingredients in the preparation of local pharmaceutical compositions for the treatment of local lesions, and the topical pharmaceutical compositions for the treatment of local lesions comprising the amino acid nutrients local active ingredients and conventional ineffective compounds , and devices comprising the composition. Background technique [0002] Solid tumors are often used as a model for studies of localized disease, especially refractory localized disease, as supported by extensive research work. A solid tumor is a tumor disease with tumor symptoms, which is a characteristic diseased tissue containing tumor cells. Taking pancreatic cancer tumors as an example, pancreatic cancer cells only account for about 30% of the tumor volume. It can be seen that in addition to tumor cells, there are often a large number of other components (someti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/195A61K31/4172A61K31/401A61K31/405A61K31/185A61K31/197A61K31/353A61P35/00A61P29/00A61P5/14A61P5/16A61P17/00A61P31/14A61P31/10A61P37/06A61P31/22A61P17/10A61P31/04A61M11/00
CPCA61K31/198A61K31/195A61K31/4172A61K31/401A61K31/405A61K31/185A61K31/197A61K31/353A61P35/00A61P29/00A61P5/14A61P5/16A61P17/00A61P31/14A61P31/10A61P37/06A61P31/22A61P17/10A61P31/04A61M11/00A61K2300/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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