Drug composition for treating prostatic hyperplasia

A technology of prostatic hyperplasia and composition, which is applied in the direction of drug combination, active ingredients of hydrocarbon compounds, medical formula, etc., can solve the problems of easy repetition, long course of treatment, slow treatment effect, etc., and achieve the goal of relieving pain, relieving symptoms, and not easy to relapse Effect

Inactive Publication Date: 2020-03-24
ANHUI UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0005] The invention provides a pharmaceutical composition for the treatment of benign prostatic hyperplasia, which is used to solve the problems that western medicine cannot be completely cured, traditional Chinese medicine is rarely used clinically, and the treatment effect is slow, the function is single, the course of treatment is long, and it is easy to repeat in the current clinical medicine.

Method used

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  • Drug composition for treating prostatic hyperplasia

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Effect test

preparation example 1

[0052] Preparation Example 1 The preparation of Pygeum africana bark extract:

[0053] Pygeum africana bark, dried and crushed, added 7 times the mass of pygeum africana bark in 40% vol ethanol aqueous solution, soaked at 40°C for 0.5h, assisted ultrasonic extraction at a constant temperature of 60°C for 1h, the ultrasonic frequency was 26KHz, and then refluxed extraction After 2 hours, the filtrate was collected by filtration and dried to obtain the bark extract of Pygeum africana.

[0054] The method does not need to use organic solvents such as ethyl acetate and dichloromethane, and adopts heating soaking combined with ultrasonic extraction, which has a high extraction rate in one extraction and does not need repeated extraction. The reagent used is ethanol, which has low toxicity, high recycling rate, and is environmentally friendly and economical.

[0055] The drying method is freeze-drying after concentration by rotary evaporation.

[0056] DHT is one of the main substa...

preparation example 2

[0057] The preparation of preparation example 2 stinging nettle root extract:

[0058] Wash, dry and pulverize the stinging nettle root, add 40% vol ethanol aqueous solution of 7 times the mass of the stinging nettle root, carry out assisted ultrasonic extraction at a constant temperature of 40°C for 1 hour, and the ultrasonic frequency is 26KHz, then reflux extraction for 1 hour, and filter to obtain the filtrate , dried to obtain stinging nettle root extract.

[0059] The drying method is vacuum drying.

[0060] The method adopts temperature rise combined with ultrasonic extraction, and the extraction rate is high in one extraction without repeated extraction. The combination of pygeum africana and stinging nettle root extracts is currently only reported for the treatment of alopecia. The report mentioned that the researchers judged that the pygeum fruit extract and stinging nettle root extract might be combined with some Some ingredients (saw palmetto fruit extract; grape...

preparation example 3

[0062] The preparation of preparation example 3 Ginkgo biloba extract:

[0063]Take ginkgo leaves, wash, dry, and crush them, add 40% vol ethanol aqueous solution with 15 times the mass of ginkgo leaves, and carry out assisted ultrasonic extraction at a constant temperature of 40°C for 1 hour. The ratio of 1.5g dry ginkgo biloba / ml concentrated solution is concentrated into a concentrated solution, and the concentrated solution is put on a D101 macroporous resin column, rinsed with deionized water first, then eluted with 70% vol ethanol deionized aqueous solution, and collected and washed Deliquified and dried to obtain Ginkgo biloba extract.

[0064] The drying method is freeze-drying after concentration by rotary evaporation.

[0065] This method does not require repeated extraction, saving time and reagent costs. The main value and application of Ginkgo biloba extract are extremely wide, but at present it is mainly used in Chinese medicine to treat memory loss, stomach pa...

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Abstract

The invention provides a drug composition for treating prostatic hyperplasia. The drug composition is composed of following components: a pygeum topengii bark extract, a urtica dioica root extract, beta-sitosterol, lycopene, zinc citrate, selenium and vitamin E. According to the drug composition for treating prostatic hyperplasia, by combining traditional Chinese medical herbs with western medicine, a compound is formed; and the drug composition rapidly comes into effect, can rapidly relieve prostatic hyperplasis symptoms and rapidly alleviate pain of patients, can achieve radical treatment and is short in treatment course, and prostatic hyperplasia does not easily relapse.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a pharmaceutical composition for treating benign prostatic hyperplasia. Background technique [0002] At present, drugs for the treatment of benign prostatic hyperplasia on the market are mainly divided into three categories: the first category, α-adrenergic receptor blockers, this type of drug is to relax those tight muscles, reduce the resistance of the urethra, and make urination easier , suitable for patients with mild symptoms of benign prostatic hyperplasia, but commonly used drugs such as silodosin have side effects such as retrograde ejaculation and erectile dysfunction; the second category, 5α-reductase inhibitors, the third category, other plant inhibitors The principle of these two types of drugs is to inactivate 5α-reductase and turn it into a decoration, that is, to prevent testosterone from becoming dihydrotestosterone even if it en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P13/08A61K31/01A61K31/355A61K31/575A61K33/04A61K33/30
CPCA61K31/01A61K31/355A61K31/575A61K33/04A61K33/30A61K36/185A61K36/73A61P13/08A61K2300/00
Inventor 李长润曾雪
Owner ANHUI UNIVERSITY
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