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Huai chrysanthemum extract liposome and preparation method and application thereof

A technology of chrysanthemum extract and liposome, which is applied in the field of daily skin care, can solve the problems of poor release performance, low anti-aging ability, and low skin storage capacity, and achieve the effects of accelerated release, stable quality, and uniform particle size distribution

Active Publication Date: 2020-04-07
克劳丽化妆品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem solved by the present invention is to overcome the defects in the prior art that the release performance of chrysanthemum chrysanthemum extract is poor, and the skin storage capacity is low, resulting in low anti-aging ability, and a kind of chrysanthemum chrysanthemum extract liposome and preparation method are provided and its use

Method used

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  • Huai chrysanthemum extract liposome and preparation method and application thereof
  • Huai chrysanthemum extract liposome and preparation method and application thereof
  • Huai chrysanthemum extract liposome and preparation method and application thereof

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Embodiment 1

[0023] The preparation of embodiment 1 Huai chrysanthemum extract

[0024] The present embodiment provides a kind of preparation method of Huai chrysanthemum extract, comprising the following steps:

[0025] Select fresh Huai chrysanthemums with good quality and put them into a drying oven, dry them at 60°C for 12 hours, crush them with a pulverizer and pass them through a 40-mesh sieve, and then ultrasonically extract them three times with an ethanol solution with a volume fraction of 75%. Ratio 1:30 (g / mL), each extraction time is 1h, filter with suction, combine the filtrates, and then concentrate under reduced pressure at 40°C to remove the solvent to obtain the chrysanthemum flower extract.

[0026] Preparation of the test solution: take 1 g of the extract of Chrysanthemum chinensis, add absolute ethanol, and set the volume to 50 mL to obtain the test solution.

[0027] Preparation of reference solution: take chlorogenic acid standard and luteolin standard respectively, ...

Embodiment 2

[0030] The present embodiment provides a kind of preparation method of chrysanthemum flower extract liposome, comprises the following steps:

[0031] Get 100 g of Chrysanthemum chinense extract prepared in Example 1 and mix with 600 g of soybean lecithin (phosphatidylcholine content greater than 70%), add 600 ml of absolute ethanol, place it at 60° C. for heating and dissolving, then remove ethanol by rotary evaporator, And 9300ml of PBS buffer solution of pH 7.4 was added thereto, with the rotating speed of 12000rpm high-speed shearing 2min to form a homogeneous emulsion, then the emulsion was circulated 4 times through a high-pressure homogenizer under a pressure of 600bar to obtain the chrysanthemum flower extract lipid body.

Embodiment 3

[0033] The present embodiment provides a kind of preparation method of chrysanthemum flower extract liposome, comprises the following steps:

[0034] Get 100 g of Chrysanthemum chinense extract prepared in Example 1 and mix with 600 g of soybean lecithin (phosphatidylcholine content greater than 70%), add 600 ml of absolute ethanol, place it at 60° C. for heating and dissolving, then remove ethanol by rotary evaporator, And 9300ml of PBS buffer solution of pH 7.4 was added thereto, with the rotating speed of 12000rpm high-speed shearing 2min to form a homogeneous emulsion, and then the emulsion was circulated 5 times through a high-pressure homogenizer under a pressure of 1200bar to obtain the lipid of the chrysanthemum chrysanthemum extract body.

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Abstract

The invention provides a Huai chrysanthemum extract liposome and a preparation method and application thereof. The Huai chrysanthemum extract liposome comprises the raw materials of, by weight, 0.5 to2 parts of Huai chrysanthemum extract, 4 to 8 parts of phospholipid, and 80 to 95 parts of buffer solution. The preparation method of the Huai chrysanthemum extract liposome comprises the steps of mixing the Huai chrysanthemum extract, the phospholipid and an organic solvent, dissolving, concentrating to remove the organic solvent, adding the buffer solution, and shearing at a high speed to obtain the Huai chrysanthemum extract liposome. The Huai chrysanthemum extract liposome prepared by the invention can obviously improve the storage capacity of the Huai chrysanthemum extract in the skin, promote skin fibrocytes to release more collagen, enhance the anti-photoaging activity of the skin fibrocytes and further improve the anti-aging ability of the skin.

Description

technical field [0001] The invention relates to the technical field of daily skin care, in particular to a chrysanthemum flower extract liposome, a preparation method and an application thereof. Background technique [0002] Skin aging can easily cause a series of problems such as wrinkles, sagging, dryness, and pigmentation of the skin. Skin aging includes two aging processes, one is natural aging, which is determined by internal genes; the other is aging caused by external environmental factors, such as ultraviolet rays and pollutants. The mechanism of skin aging is very complex. Most of the current anti-aging cosmetics use industrial ingredients with strong antioxidant properties in order to achieve a better anti-aging effect. Although they have quick results in a short period of time, long-term use is extremely harmful to the human body. [0003] Chrysanthemum chrysanthemum is sweet, bitter and slightly cold. It returns to the lung and liver meridian. County and other...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/39A61K8/14A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/39A61K8/14A61Q19/00A61Q19/08
Inventor 周华锋周建青杜兆阳徐晓平
Owner 克劳丽化妆品股份有限公司
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