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Astaxanthin freeze-dried powder and preparation method thereof

A technology of astaxanthin and freeze-dried powder, which is applied in the direction of freeze-drying transportation, powder transportation, pharmaceutical formulations, etc., can solve the problems of large loss of astaxanthin activity, poor water solubility, poor shape-forming effect, etc., and achieve astaxanthin activity High degree of retention and good stability

Inactive Publication Date: 2020-04-07
福建启元堂生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The above-mentioned patent discloses a freeze-dried astaxanthin powder for cosmetic use, which is obtained by mixing excipients with astaxanthin and freezing, and natural astaxanthin mainly exists in the form of astaxanthin ester, which is an oil-soluble Substances with extremely poor water solubility, resulting in poor excipient effect and large loss of activity of astaxanthin

Method used

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  • Astaxanthin freeze-dried powder and preparation method thereof

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Embodiment 1

[0040] A preparation method of astaxanthin freeze-dried powder, comprising the steps of:

[0041] 1) Mix fatty acid glycerides, lecithin, and tocopherol according to 3.6:1:1 to make an oil solution;

[0042] 2) Dissolve 1 kg of astaxanthin ester in 5.6 L of oil solution at 40°C to obtain astaxanthin ester solution;

[0043] 3) Add 4.0L of chitosan solution with a mass concentration of 50% to the astaxanthin ester solution obtained in step 2), and keep the temperature at 42°C for 30 minutes;

[0044] 4) Add Tween 80 to the astaxanthin ester-chitosan solution prepared in step 3) at 60°C, then add pH 7.0 phosphate buffer solution pre-dissolved with ethylenediaminetetraacetic acid, homogenize at high speed , until the system is uniform, and an emulsion is obtained;

[0045] 5) 4.5 kg of astaxanthin emulsion obtained in step 4) was added with 88 kg of excipient mannitol, stirred evenly, and freeze-dried to obtain astaxanthin freeze-dried powder.

Embodiment 2

[0047] 1) Mix fatty acid glycerides and lecithin at a ratio of 4.5:1 to make an oil solution;

[0048] 2) Dissolve 1kg of astaxanthin ester extracted from Haematococcus cells in 5.6L oil solution at 55°C to obtain astaxanthin ester solution;

[0049] 3) Add 4.0L of chitosan solution with a mass concentration of 32% to the astaxanthin ester solution obtained in step 2), and keep the temperature at 52°C for more than 30 minutes;

[0050] 4) Add polyglycerol ester to the astaxanthin ester-chitosan solution prepared in step 3) at 55°C, then add ascorbic acid pre-dissolved pH 7.0 phosphate buffer solution, homogenize at high speed until the system is uniform , to obtain an emulsion;

[0051] 5) Take 1.5 kg of astaxanthin emulsion obtained in step 4), add 85 kg of excipient mannitol, stir evenly, and freeze-dry to obtain astaxanthin freeze-dried powder.

Embodiment 3

[0053] 1) Mix fatty acid glycerides and lecithin at a ratio of 4.0:1 to make an oil solution;

[0054] 2) 1kg of astaxanthin ester extracted from Haematococcus cells was dissolved in 5.6L oil solution at 20°C to obtain astaxanthin ester solution;

[0055] 3) Add 4.0L of chitosan solution with a mass concentration of 45% to the astaxanthin ester solution obtained in step 2), and keep the temperature at 50°C for more than 30 minutes;

[0056] 4) Add polyglycerol ester to the astaxanthin ester-chitosan solution prepared in step 3) at 58°C, then add phosphate buffer solution, homogenize at high speed until the system is uniform, and obtain an emulsion;

[0057] 5) Add 6 kg of astaxanthin emulsion obtained in step 4), add 90 kg of excipient mannitol, stir evenly, freeze-dry to obtain astaxanthin freeze-dried powder.

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Abstract

The invention relates to the field of astaxanthin products, particularly to astaxanthin freeze-dried powder and a preparation method thereof. The astaxanthin freeze-dried powder comprises astaxanthinester, fatty glyceride, lecithin, chitosan, an emulsifier, a stabilizer, water and an excipient. The addition amount of the chitosan is 1.2-1.5 times of the mass of the astaxanthin ester. Astaxanthinester is dissolved in an oil phase, chitosan is added, emulsification and stabilization are performed to form emulsified liquid; and then shaping is performed to obtain freeze-dried powder. The utilization rate of astaxanthin is high and the activity retention degree of astaxanthin is high.

Description

technical field [0001] The invention relates to the field of astaxanthin products, in particular to a freeze-dried astaxanthin powder and a preparation method thereof. Background technique [0002] Astaxanthin (English: Astaxanthin, also known as astaxanthin or astaxanthin), is a kind of carotenoid, which is a strong natural antioxidant. Like other carotenoids, astaxanthin is a fat-soluble and water-soluble pigment that can be found in marine organisms such as shrimp, crab, salmon, and algae. The antioxidant capacity of astaxanthin is 550 times that of vitamin E and 10 times that of β-carotene. Therefore, astaxanthin is packaged as a health food and sold in the market, which has a considerable market prospect. [0003] Currently on the market, astaxanthin is mostly added to products as an additive. However, since astaxanthin is unstable and easily decomposed by light, heat, and high temperature, it is better to exist in the form of astaxanthin freeze-dried powder. The fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/232A61K47/14A61K47/24A61K47/26A61P39/06A61K8/37A61K8/55A61K8/73A61K8/02A61Q19/08A23L33/10A23L33/105A23L2/52A23L29/00A23L29/30A23L29/10
CPCA23L2/52A23V2002/00A61K8/022A61K8/375A61K8/553A61K8/736A61K9/19A61K31/232A61K47/14A61K47/24A61K47/26A61Q19/08A23L29/035A23L29/04A23L29/05A23L29/10A23L29/30A23L33/10A23L33/105A61P39/06A23V2200/30A23V2250/21A23V2250/2042A23V2250/1842A23V2250/18A23V2250/712A23V2250/511A23V2250/6418A23V2250/1618A23V2250/708A23V2250/314A23V2250/6406A23V2250/636
Inventor 余建忠
Owner 福建启元堂生物技术有限公司
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