Application of malonic-acid-modified fullerene C70 in preparation of medicine for treating non-alcoholic fatty liver disease

A technology for non-alcoholic and fatty liver disease, applied in the field of preparation of drugs for the treatment of non-alcoholic fatty liver disease, can solve problems such as difficult quality control, harsh preparation method conditions, and limited medicinal value, so as to reduce the damage of carbon cages , Retain the efficacy and activity of the medicine, which is beneficial to the effect of finished medicine
CN110960553APending Publication Date: 2020-04-07武汉赛莱亚生物科技有限公司
3 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
武汉赛莱亚生物科技有限公司
Publication Date
2020-04-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses application of malonic-acid-modified fullerene C70 in preparation of a medicine for treating the non-alcoholic fatty liver disease. The medicine that uses the C70-malonic acidderivative as the active ingredient and is used for preventing, relieving and / or treating the non-alcoholic fatty liver disease and related diseases has the following advantages: firstly, the pharmacodynamic effect is obvious, the C70-malonic acid derivative can obviously inhibit lipid accumulation in primary hepatocytes of mice and obvious changes can be seen in 10 micrometers; in addition, the C70-malonic acid derivative also has an obvious improvement effect on liver lipid accumulation and fibrosis generated by HFHC diet induction; secondly, the malonic-acid-modified fullerene C70 can effectively reduce the damage of a carbon cage in a fullerene modification process, so that the pharmacodynamic activity of the fullerene body is better retained; and thirdly, the C70-malonic acid derivative has a determined molecular structure, problems that other water-soluble fullerene derivatives have no determined structure and are difficult in quality control are solved, and the patent medicine is realized conveniently.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of nano-biomedicine, in particular to the application of malonate-modified fullerene C70 in the preparation of drugs for treating non-alcoholic fatty liver disease. Background technique

[0002] With the improvement of people's living standards and changes in lifestyle, the number of patients with nonalcoholic fatty liver disease (NAFLD) in China is increasing year by year, and it has become an important cause of chronic liver disease. According to statistics, there are currently more than 1 billion non-alcoholic fatty liver patients in the world, and the incidence of NAFLD among adults in my country is about 20% [1-3]. Patients with NAFLD usually have no history of excessive alcohol consumption, and are characterized by diffuse hepatic macrovesicular steatosis and fat accumulation. Moreover, if nonalcoholic fatty liver is not treated in time, it can also develop into nonalcoholic steatohepatitis (NASH), liver fibros...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More