A neovascular construct for implanting into the subcutaneous tissue of a subject and its preparation method

A subcutaneous tissue, subject technology, used in catheters, pharmaceutical formulations, drug delivery, etc., can solve problems such as graft wear, inflammation, bleeding, etc.

Active Publication Date: 2022-03-15
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the longest duration of this method is about 5 years, and intrahepatic transplantation still has risks such as intrahepatic transplantation site bleeding, inflammation, graft wear and local fatty degeneration

Method used

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  • A neovascular construct for implanting into the subcutaneous tissue of a subject and its preparation method
  • A neovascular construct for implanting into the subcutaneous tissue of a subject and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing a neovascular construct for implanting into subcutaneous tissue of a subject, comprising:

[0046] Weigh 1.2g of polymer material (L-polylactic acid, PLLA, molecular weight 48000Da), put it in a 30ml glass beaker, add 10ml of organic solvent (hexafluoroisopropanol) into the beaker, and fully dissolve it to obtain an electrospinning solution.

[0047]Use a pipette to transfer the electrospinning solution from the beaker into a special electrospinning storage syringe, install the electrospinning nozzle (22G), adjust the electrospinning flow rate to 3.0mL / h, the voltage to 18kV, and the distance between the nozzle and the receiving device The receiving device is a cylindrical stainless steel tube with an outer diameter of 1.8 cm, the rotating speed of the receiving device is adjusted to 800 rpm, and the nanofiber catheter is obtained by electrospinning for 28 hours. Cut the nanofiber catheter into corresponding long sections as required, put it into ...

Embodiment 2

[0049] This embodiment provides a preparation method for implanting a neovascular construct into the subcutaneous tissue of a subject, which is roughly the same as the preparation method provided in Example 1, except that the polymer material and the organic solvent are different, and the difference is as follows:

[0050] The polymer material is a polylactic acid glycolic acid copolymer obtained by copolymerization of lactic acid and glycolic acid with a molar ratio of 75:25;

[0051] The organic solvent is trifluoroethanol.

Embodiment 3

[0053] This embodiment provides a preparation method for implanting a neovascular construct into the subcutaneous tissue of a subject, which is roughly the same as the preparation method provided in Example 1, except that the polymer material and the organic solvent are different, and the difference is as follows:

[0054] The polymer material is polyglycolic acid;

[0055] The organic solvent is tetrahydrofuran.

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Abstract

The invention discloses a new blood vessel construct for implanting into subcutaneous tissue of a subject and a preparation method thereof, and relates to the technical field of polymer materials. The neovascular construct is a nanofiber catheter made of the polymer material by electrospinning, and the material is selected from one of L-polylactic acid, D-polylactic acid, polylactic-co-glycolic acid copolymer and polyglycolic acid , the vascular construct prepared by using the polymer material is transplanted into the subcutaneous tissue, which can quickly form an extracellular matrix space rich in new blood vessels in the subcutaneous tissue of the subject, which is used to accommodate the donor-derived islets or islet cells for long-term maintenance of function.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a neovascular construct for implanting into subcutaneous tissue of a subject and a preparation method thereof. Background technique [0002] Type I diabetes, formerly known as insulin-dependent diabetes, occurs in children or adolescents, and can also occur in various ages, especially menopause. It is a disease that is almost difficult to cure. The lack of islet cell function in the patient's body makes the patient prone to Ketoacidosis must be treated with insulin injections for life, otherwise it will be life-threatening. [0003] There are two goals of insulin therapy for type I diabetes. One is to ensure that patients have a good quality of life (that is, to avoid severe hypoglycemia as much as possible), and the other is to control metabolic levels to prevent diabetic complications. However, long-term insulin injections can lead to a series of complications, inclu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/06A61L29/14
CPCA61L29/06A61L29/14A61L29/148A61L2400/12C08L67/04
Inventor 牛玉清夏慧敏张锐忠付铭
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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