A kind of cefcapene hydrochloride granule and preparation method thereof

A technology of cefcapene pivoxil hydrochloride and granules, which can be used in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., and can solve the difficulty of disintegration of cefcapene pivoxil hydrochloride tablets, unqualified dissolution rate, and low yield of finished products and other problems, to achieve the effect of simple formula and process, high yield of finished product and good stability
CN110974803BActive Publication Date: 2022-03-11SHANDONG LUOXIN PHARMA GRP CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG LUOXIN PHARMA GRP CO LTD
Publication Date
2022-03-11

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Abstract

The invention relates to the technical field of medicine, in particular to a granule of cefcapene pivoxil hydrochloride and a preparation method thereof. The composition comprises cefcapene pivoxil hydrochloride, microcrystalline cellulose, mannitol, and croscarmellose sodium , hypromellose, talc, stevia. The obtained cefcarpine pivoxil hydrochloride has good stability, rapid disintegration, good taste, good curative effect, and obvious anti-inflammatory effect, and the anti-inflammatory effect is significantly higher than that of the prior art.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefcapene hydrochloride granule and a preparation method thereof. Background technique

[0002] Cefcapene pivoxil hydrochloride (cefcapene pivoxil hydrochloride), its chemical name is (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenylamino]-3 -[(aminocarbonyl)oxy]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl Oxypropoxymethyl) ester hydrochloride monohydrate, its structural formula is as follows:

[0003]

[0004] Cefcapene pivoxil hydrochloride was developed by Shionogi Co., Ltd. of Japan. It has two specifications of 75mg and 100mg tablets, and 100mg granules. It is used to treat epidermal infections, deep skin infections, chronic pyoderma, and trauma caused by sensitive bacteria. Secondary infection of wounds such as burns and surgical trauma, mastitis, perianal abscess, pharyngitis, laryngitis, tonsillitis (including peritons...

Claims

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