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An anti-inflammatory and antibacterial composite skin scaffold material and its preparation method

A scaffold material and skin technology, applied in the field of anti-inflammatory and antibacterial composite skin scaffold materials and preparation, can solve the problems of the adhesion of scar scaffold materials, easy infection of wound skin, inflammation, etc., so as to improve wound healing and regeneration ability, improve mechanical properties Performance, immune-enhancing effect

Active Publication Date: 2022-02-01
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to address the deficiencies of the prior art, to provide an anti-inflammatory and antibacterial composite skin scaffold material and its preparation method. The present invention combines the hyaluronic acid scaffold and the polycaprolactone scaffold to prepare a composite skin by using two freeze-drying techniques. The stent material solves the problem of easy infection, inflammation and scarring of the wound skin and the weak adhesion of the stent material

Method used

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  • An anti-inflammatory and antibacterial composite skin scaffold material and its preparation method

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Embodiment 1

[0029] An anti-inflammatory and antibacterial composite skin scaffold material, the anti-inflammatory and antibacterial composite skin scaffold material is composed of a hyaluronic acid dermis scaffold and a polycaprolactone epidermal scaffold; the composite skin scaffold is loaded with sodium alginate gel particles Balls, the sodium alginate gel microspheres contain superoxide dismutase and gallic acid, the weight ratio of the sodium alginate, superoxide dismutase and gallic acid is 3:1:1.2; the hyaluronic acid Copper ions and zinc ions are complexed on the acid scaffold; the hyaluronic acid & polycaprolactone double-layer porous scaffold is made by freeze-drying technology; the thickness of the hyaluronic acid scaffold layer is 2.8 mm, and the pore size is 55 μm ; The polycaprolactone stent layer has a thickness of 0.4 mm and a pore size of 18 μm.

[0030] A preparation method of an anti-inflammatory and antibacterial composite skin support material, specifically comprising ...

Embodiment 2

[0036]An anti-inflammatory and antibacterial composite skin scaffold material, the anti-inflammatory and antibacterial composite skin scaffold material is composed of a hyaluronic acid dermis scaffold and a polycaprolactone epidermal scaffold; the composite skin scaffold is loaded with sodium alginate gel particles Balls, the sodium alginate gel microspheres contain superoxide dismutase and gallic acid, the weight ratio of the sodium alginate, superoxide dismutase and gallic acid is 2:1:1; the hyaluronic acid Copper ions and zinc ions are complexed on the acid scaffold; the hyaluronic acid & polycaprolactone double-layer porous scaffold is made by freeze-drying technology; the thickness of the hyaluronic acid scaffold layer is 1.2 mm, and the pore size is 95 μm ; The polycaprolactone stent layer has a thickness of 0.08 mm and a pore size of 30 μm.

[0037] A preparation method of an anti-inflammatory and antibacterial composite skin support material, specifically comprising th...

Embodiment 3

[0043] An anti-inflammatory and antibacterial composite skin scaffold material, the anti-inflammatory and antibacterial composite skin scaffold material is composed of a hyaluronic acid dermis scaffold and a polycaprolactone epidermal scaffold; the composite skin scaffold is loaded with sodium alginate gel particles Balls, the sodium alginate gel microspheres contain superoxide dismutase and gallic acid, the weight ratio of the sodium alginate, superoxide dismutase and gallic acid is 4:1:1.5; the hyaluronic acid Copper ions and zinc ions are complexed on the acid scaffold; the hyaluronic acid & polycaprolactone double-layer porous scaffold is made by freeze-drying technology; the thickness of the hyaluronic acid scaffold layer is 4.5 mm, and the pore size is 117 μm ; The thickness of the polycaprolactone scaffold layer is 0.8 mm, and the pore size is 48 μm.

[0044] A preparation method of an anti-inflammatory and antibacterial composite skin support material, specifically com...

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Abstract

The invention provides an anti-inflammatory and antibacterial composite skin scaffold material, the composite skin scaffold material is composed of a hyaluronic acid dermis scaffold and a polycaprolactone epidermal scaffold; the composite skin scaffold is loaded with sodium alginate gel particles The sodium alginate gel microspheres contain superoxide dismutase and gallic acid; copper ions and zinc ions are complexed on the hyaluronic acid scaffold; The composite skin scaffold material is obtained by combining the scaffold and the polycaprolactone scaffold, which solves the problems of easy infection, inflammation and scarring of the wound skin and the weak adhesion of the scaffold material, and the skin scaffold material not only has good biocompatibility and Adhesive, good mechanical properties, inorganic body rejection, biodegradable, degraded products have no toxicity and no abnormal reaction to biological tissues, the preparation method is simple, and it is green and environmentally friendly.

Description

technical field [0001] The invention belongs to the field of biological scaffold materials, and in particular relates to an anti-inflammatory and antibacterial composite skin scaffold material and a preparation method thereof. Background technique [0002] Scaffold materials are the most basic components of tissue engineering materials. As templates and substrates for regeneration, as well as places where cells obtain nutrients and grow and metabolize, scaffold materials not only provide a suitable environment for the growth of cells and tissues, but also provide a reliance for cell proliferation. Based on the material basis of attachment, it can also regulate and induce the differentiation of cells and tissues to form new functional tissues and organs. The scaffold material gradually degrades and disappears with the construction of the tissue, and provides new space for the tissue and cells, and finally achieves the purpose of tissue regeneration and repair. [0003] The s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/60A61L27/20A61L27/18A61L27/04A61L27/22A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/60A61L27/20A61L27/18A61L27/047A61L27/227A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/602A61L2300/412A61L2300/404A61L2300/41A61L2300/254A61L2300/21A61L2300/102A61L2300/622C08L5/08C08L67/04C08L5/04C08L89/00
Inventor 张正男段书霞韩涵付迎坤林建香石沛龙崔彬彬王红磊韩修恒田崇于肇锦郝明严子跃佘开江
Owner HENAN YADU IND