A kind of hydrogel dressing for treating psoriasis and preparation method thereof

A hydrogel and psoriasis technology, which is applied in the field of external psoriasis treatment materials, can solve the problems of high price and recurrence, achieve the effect of no cytotoxicity, reduce the expression of inflammatory factors, and improve the treatment effect

Active Publication Date: 2021-08-27
JIANGXI DONGPENG NEW MATERIALS +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These three methods all have the disadvantages of recurrence after discontinuation and high price. It is urgent to find a new effective and low-cost method for the treatment of psoriasis

Method used

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  • A kind of hydrogel dressing for treating psoriasis and preparation method thereof
  • A kind of hydrogel dressing for treating psoriasis and preparation method thereof
  • A kind of hydrogel dressing for treating psoriasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Dissolve 0.4g of alginic acid and 0.1863g of rubidium chloride in 10ml of deionized water, and react with magnetic stirring for 30min at 30°C and a stirring speed of 400r / min (a large number of bubbles are generated during the reaction process, as the reaction time prolongs, Bubbles gradually disappear), to obtain rubidium alginate solution. Dissolve 0.2736g of sodium alginate in 9ml of deionized water to obtain a sodium alginate solution, then add 1ml of rubidium alginate solution to the sodium alginate solution, then stir magnetically at 40°C and 400r / min for 20min, Mix the two evenly to obtain an alginate solution. Put 1.68g of acrylamide, 0.65g of gluconolactone GDL, 0.1288g of basic magnesium carbonate, and 0.036g of basic zinc carbonate into the above-mentioned alginate solution (10ml), at 40°C and a stirring speed of 400r / min, Magnetic stirring was carried out for 30 minutes, and after uniform mixing, a pre-crosslinking solution was obtained. Add 0.01g of methy...

Embodiment 2

[0066] Dissolve 0.405g of alginic acid and 0.2794g of rubidium chloride in 15ml of deionized water, and react with magnetic stirring for 30min at 60°C and a stirring speed of 500r / min (a large number of bubbles are generated during the reaction process, as the reaction time prolongs, Bubbles gradually disappear), to obtain rubidium alginate solution. Dissolve 0.1520g of sodium alginate in 5ml of deionized water to obtain a sodium alginate solution, then add 5ml of rubidium alginate solution to the sodium alginate solution, then stir magnetically at 40°C and 600r / min for 20min, Mix the two evenly to obtain an alginate solution. Put 1.68g of acrylamide, 0.65g of gluconolactone GDL, 0.1288g of basic magnesium carbonate, and 0.036g of basic zinc carbonate into the above-mentioned alginate solution (10ml), at 40°C and a stirring speed of 400r / min, Magnetic stirring was carried out for 30 minutes, and after uniform mixing, a pre-crosslinking solution was obtained. Add 0.01g of met...

Embodiment 3

[0068] Dissolve 0.27g of alginic acid and 0.1831g of rubidium chloride in 10ml of deionized water, and react with magnetic stirring for 30min at 50°C and a stirring speed of 200r / min (a large number of bubbles are generated during the reaction process, as the reaction time prolongs, Bubbles gradually disappear), to obtain rubidium alginate solution. Put 1.68g of acrylamide, 0.65g of gluconolactone GDL, 0.1288g of magnesium carbonate, and 0.036g of basic zinc carbonate into the above-mentioned rubidium alginate solution (10ml) successively, at 20°C and a stirring speed of 800r / min, magnetically stir After 30 minutes, after mixing evenly, a pre-crosslinking solution was obtained. Add 0.01g of methylenebisacrylamide (MBAA), 10μl of tetramethylethylenediamine (TEMED), and 0.03g of ammonium persulfate (APS) to the above-mentioned pre-crosslinking solution (15ml) in sequence and heat at 500r / min Stir completely at a certain stirring speed, pour it into a glass container, irradiate ...

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Abstract

The invention belongs to the technical field of external psoriasis treatment materials, in particular to a hydrogel medical dressing for the treatment of psoriasis, which is alginate / polyacrylamide interpenetrating network structure water chemically cross-linked with rubidium, magnesium and zinc ions gel. In addition, the present invention also provides the preparation method of the dressing and its application in the preparation of preparations for treating psoriasis. The interpenetrating network hydrogel of the present invention is innovatively chemically cross-linked rubidium, magnesium and zinc ions in the alginate / polyacrylamide interpenetrating network structure hydrogel, through the interpenetrating network polymer and The interaction of the cross-linked rubidium, magnesium and zinc ions has no obvious toxicity to the proliferation of stratum corneum cells, can reduce the expression of inflammatory genes in stratum corneum cells, and achieve the purpose of treating psoriasis.

Description

technical field [0001] The invention belongs to the technical field of external psoriasis treatment materials, in particular to a hydrogel medical dressing for treating psoriasis. Background technique [0002] Psoriasis (commonly known as psoriasis) is an immune-mediated chronic inflammatory skin disease with a long course of disease and a tendency to relapse, and some cases are almost unhealed for life; the clinical manifestations are mainly erythema and scales, which can be used all over the body The onset is more common on the scalp and the extensor sides of the extremities, and it is mostly aggravated in winter. It is estimated that the population with psoriasis accounts for about 1-2% of the world's population, and the number of patients in China is 7-8 million. [0003] Psoriasis is an immune-mediated inflammatory disease. The traditional treatment options are mainly divided into three categories: immunosuppressants, phototherapy and ozone therapy. These three method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61K9/06A61K47/36A61K47/32A61P17/06A61P29/00C08F251/00C08F220/56C08F222/38C08F2/48C08B37/04A61K33/10A61K33/06A61K33/24
CPCA61K9/0014A61K9/06A61K33/06A61K33/10A61K33/24A61K33/30A61P17/06A61P29/00C08B37/0084C08F2/48C08F251/00C08F220/56A61K2300/00
Inventor 刘咏和祥谭彦妮王平卫
Owner JIANGXI DONGPENG NEW MATERIALS
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