Bioactive silicon regenerative medical material and preparation method thereof

A technology for bioactive silicon and medical materials, applied in the field of bioactive silicon regenerative medical materials and their preparation, can solve the problems of increasing the alcohol solvent recovery system, the influence of material uniformity, equipment corrosion, etc., and achieve the aging and drying process. The effect of short time, simple operation method and high production efficiency

Active Publication Date: 2020-04-17
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current sol-gel process is realized by using organic silicon raw materials such as hydrolyzed ethyl orthosilicate as the silicon precursor, but the hydrolysis process of ethyl orthosilicate has poor miscibility with water, and the hydrolysis process requires It is difficult to catalyze in an acidic environment or an alkaline environment; in order to increase its miscibility with wat

Method used

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  • Bioactive silicon regenerative medical material and preparation method thereof
  • Bioactive silicon regenerative medical material and preparation method thereof
  • Bioactive silicon regenerative medical material and preparation method thereof

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preparation example Construction

[0036] In a second aspect, the present invention provides a method for preparing the biosilicon material of the above-mentioned first aspect, the method comprising:

[0037] Step 1. Preparation of the total mixed solution: add silica sol, surfactant, phosphate esters, and calcium-containing salts into the reactor to obtain the total mixed solution. Specifically include:

[0038] Sub-step 1: Add silica sol and surfactant into the reactor, then stir evenly, measure and record the pH value, and obtain mixed solution A.

[0039] The above-mentioned determination of the pH value is to clarify which pH value regulator is selected in the following steps, corresponding to the pH value adjustment step. Sub-step 2: Add phosphoric acid esters into the reactor under stirring, heat to 40-50° C. and stir for 20-40 minutes, preferably 30 minutes, to obtain mixed solution B. If the above-mentioned heating temperature is too low, it is not conducive to the reaction, but if the temperature ex...

Embodiment 1

[0050] A formula for synthesizing bioactive silicon regenerative medical materials using silica sol as a silicon precursor, comprising the following molar fractions:

[0051]

[0052] The preparation method of the bioactive silicon regenerative medicine material formula of the present embodiment is as follows:

[0053] (1) First, add ZS-30 silica sol into the reactor, add surfactant and stir evenly, the pH is determined to be 7.20, and recorded.

[0054] (2) Then, the phosphoric acid esters were added into the reactor under stirring, heated to 45° C. and stirred for 30 minutes.

[0055] (3) Then, calcium-containing salts are added into the reactor in the form of a saturated solution and stirred for 60 minutes.

[0056] (4) Then, the pH value of the reaction product was adjusted to 5.0 with a pH regulator, and aged at 40° C. for 12 hours, the solution completely turned into a uniform gel state.

[0057] (5) Then, the gel was broken into small pieces and baked at 100° C. fo...

Embodiment 2

[0066] A formula for synthesizing bioactive silicon regenerative medical materials using silica sol as a silicon precursor, comprising the following molar fractions:

[0067]

[0068] The preparation method of the bioactive silicon regenerative medicine material formula of the present embodiment is as follows:

[0069] (1) First, add ZS-30 silica sol into the reactor, add surfactant and stir evenly, the pH value is determined to be 7.21 and recorded.

[0070] (2) Then, the phosphoric acid esters were added into the reactor under stirring, heated to 45° C. and stirred for 30 minutes.

[0071] (3) Then, calcium-containing salts are added into the reactor in the form of a saturated solution and stirred for 60 minutes.

[0072] (4) Then, adjust the pH value of the reaction product to 5.0 with a pH regulator, and age at 40° C. for 12 hours, and the solution completely becomes a uniform gel state;

[0073] (5) Then, the gel was broken into small pieces and baked at 100° C. for ...

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Abstract

The invention relates to the field of novel biomedical materials, in particular to a bioactive silicon regenerative medical material and a preparation method thereof. The material comprises a scaffoldwhich is formed by accumulating nanoscale silicon dioxide particles and has a porous structure, and calcium and phosphorus elements which are uniformly distributed in the scaffold, and is a calcium phosphosilicate compound with biological activity, wherein the specific surface area is 200-350 m <2>/g; the material is prepared from the following components in percentage by mole: 28.5 to 81 percentof SiO2, 2.7 to 14.0 percent of P2O5 and 16.2 to 57.5 percent of CaO. The material is prepared from the following components in parts by weight: 25 to 75 parts of silicon dioxide sol, 5 to 15 parts of phosphate esters, 0.01 to 0.2 part of a surfactant, 15 to 50 parts of calcium-containing salt and 0.5 to 1.5 parts of a pH regulator. According to the method, the problems that a solvent is requiredto be used in the process of synthesizing the bioactive silicon regenerative medical material by taking tetraethoxysilane and the like as silicon precursors, the solvent is difficult to recover, theproduction period is long, and the corrosion of a catalyst to equipment is large are solved; in addition, the silicon dioxide sol with a large specific surface area is introduced, so that the bioactive silicon regenerative medical material with a larger specific surface area is synthesized, and the biological activity is stronger.

Description

technical field [0001] The invention relates to the field of biomedical new materials, in particular to a bioactive silicon regenerative medical material and a preparation method thereof. Background technique [0002] New bioactive materials have always been the focus of research in the field of medical materials. Compared with polymer medical materials that can cause rejection, and metal medical materials that can cause side effects such as thermal necrosis, inorganic non-metallic bioactive materials are relatively safe due to their high safety. more accepted by people. Among them, the research is relatively mature, relying on the stability of silicon and the development of inorganic silicon bioactive materials, including the traditional bioactive glass made by glass melting process; and the recently developed hydrolyzed organosiloxane, and Bioactive silicon materials manufactured by sol-gel process; the latter has become a research and development hotspot due to its more ...

Claims

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Application Information

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IPC IPC(8): C01B33/146C01B33/158A61L27/02A61L27/12A61L27/56
CPCA61L27/025A61L27/12A61L27/56C01B33/146C01B33/158C01P2002/72C01P2004/03C01P2006/12
Inventor 胡方郭创洲仇越秀
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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