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Preparation method of selenium-supporting chitosan microsphere with slow release effect

A technology of chitosan microspheres and chitosan, which is applied in the field of preparation of selenium-loaded chitosan microspheres, can solve the problems of poisoning of the ingested body, low encapsulation rate, difficulty in controlling the dosage, etc., and achieves stable sustained release capability. , the effect of reducing the probability of leakage

Inactive Publication Date: 2020-05-08
长沙而道新能源科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive intake of selenium can easily cause poisoning of the intake subject, which is harmful to the body.
At present, clinically, selenium-containing drugs have strong efficacy, but their dosage is difficult to control, and the encapsulation efficiency is usually low (50-70%), which may cause a large amount of selenium-containing drugs to leak from the outer membrane
The above two possibilities greatly increase the uncontrollability of selenium-containing drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of preparation method of the selenium-loaded chitosan microsphere with slow-release effect, comprises the following steps:

[0029] S1. Dissolve 2g of selenate and 5g of polyvinyl alcohol in a mixed solution of 100g of ethanol and water (the mass ratio of ethanol: water is 1:1) to form solution A, wherein the number average molecular weight of polyvinyl alcohol is 400.

[0030] S2. the chitosan of 100g carboxymethylation is dissolved in the 500g aqueous solution containing 0.5g emulsifier Span-20, forms solution B;

[0031] S3. drop solution B into solution A, stir evenly to obtain a mixed solution;

[0032] S4. Add 1 g of cross-linking agent glyoxal to the mixed solution, stir at 30° C., and add 0.5 g of dispersing agent carboxymethyl cellulose to it after a precipitate is formed, and sonicate to form solid particles;

[0033] S5. After filtering, the solid particles are collected and air-dried to obtain selenium-loaded chitosan microspheres with sustained rele...

Embodiment 2

[0039] A kind of preparation method of the selenium-loaded chitosan microsphere with slow-release effect, comprises the following steps:

[0040] S1. 5g selenate and 10g polyvinyl alcohol are dissolved in the mixed solution of 100g propanol and water (propanol: the mass ratio of water is 2:1), form solution A, wherein the number average molecular weight of polyvinyl alcohol is 2000 .

[0041] S2. the chitosan of 100g hydroxyethylation is dissolved in the 500g aqueous solution containing 0.5g emulsifier Span-80, forms solution B;

[0042] S3. drop solution B into solution A, stir evenly to obtain a mixed solution;

[0043] S4. Add 1.5 g of cross-linking agent malondialdehyde to the mixed solution, stir at 50° C., after forming a precipitate, add 0.5 g of dispersant hydroxyethyl cellulose to it, and sonicate to form solid particles;

[0044] S5. After filtering, the solid particles are collected and air-dried to obtain selenium-loaded chitosan microspheres with sustained relea...

Embodiment 3

[0050] A kind of preparation method of the selenium-loaded chitosan microsphere with slow-release effect, comprises the following steps:

[0051] S1. 4g selenate and 8g polyvinyl alcohol are dissolved in the mixed solution of 100g ethanol and water (ethanol: the mass ratio of water is 2.5:1), form solution A, wherein the number average molecular weight of polyvinyl alcohol is 1500.

[0052] S2. the chitosan of 100g sulfoylation is dissolved in the 500g aqueous solution containing 0.5g emulsifier Tween-80, forms solution B;

[0053] S3. drop solution B into solution A, stir evenly to obtain a mixed solution;

[0054] S4. Add 1.5 g of the cross-linking agent succinic dialdehyde to the mixed solution, stir at 40° C., and after the precipitate is formed, add 0.5 g of the dispersant polyacrylamide therein, and ultrasonicate to form solid particles;

[0055] S5. After filtering, the solid particles are collected and air-dried to obtain selenium-loaded chitosan microspheres with sus...

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PUM

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Abstract

The invention discloses a preparation method of a selenium-supporting chitosan microsphere with a slow release effect. The preparation method comprises the following steps: S1 dissolving selenate andpolyvinyl alcohol in a mixed solution of alcohol and water to form a solution A; S2 dissolving chitosan in an aqueous solution containing an emulsifier to form a solution B; S3 dropping the solution Bin the solution A, and carrying out uniform mixing to obtain a mixed solution; S4 adding a crosslinking agent to the mixed solution, performing stirring at 30-50 DEG C, after a precipitate is formed,adding a dispersing agent, and carrying out ultrasonic treatment to form solid particles; S5 after filtration, collecting the solid particles, and performing air drying to obtain the selenium-supporting chitosan microsphere with the slow release effect. A selenium-containing medicine in the chitosan microsphere can be stably released in a longer period, the entrapment efficiency of the selenium-containing medicine is up to 70% or above, and the probability of leakage of the selenium-containing from chitosan outer membranes is greatly reduced.

Description

technical field [0001] The invention belongs to the field of drug sustained release, and in particular relates to a preparation method of selenium-loaded chitosan microspheres with sustained release effect. Background technique [0002] Chitosan (chitosan, CS) is the only natural polycationic weakly alkaline polysaccharide. In addition to its physiological activities such as hemostasis and antibacterial in vivo, it is non-toxic, good biocompatibility and degradability, and is known as It is one of the most promising drug-loading materials. Domestic and foreign studies have prepared chitosan into targeted drug delivery materials such as micro / nanospheres, which play an important role in drug delivery, sustained release, and controlled release. Carriers of raw materials, metronidazole, indomethacin, aspirin, ibuprofen, etc.), carriers of biological macromolecular drugs (such as vaccines, proteins, polypeptides), anticancer drugs (such as mitomycin, cisplatin, paclitaxel, Cam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K33/04A61K47/36A61K47/32A61P3/02C08F8/14C08F16/06
CPCA61K9/5026A61K9/5036A61K33/04A61P3/02C08F8/14C08F16/06
Inventor 肖玉连
Owner 长沙而道新能源科技有限公司