Antibody drug conjugate of CLDN 18.2-resistant antibody and preparation method and application of antibody drug conjugate

A technology of conjugates and drugs, which is applied in the field of biomedicine and can solve problems such as lack of
CN111110862APending Publication Date: 2020-05-08L&L BIOPHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
L&L BIOPHARMA CO LTD
Publication Date
2020-05-08

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Abstract

The present invention discloses an antibody drug conjugate of a CLDN 18.2-resistant antibody. The structure of the antibody drug conjugate (ADC) is shown as Ab-[(L2)n-L1-D]y in a formula I, wherein Dis a small-molecule cytotoxic drug, L1 and L2 are connected to the drug and the antibody separately, and n is 0 or 1; y represents the average number of D which is coupled to Ab, 0 < y <= 10, and Ab is an antibody which can be specifically bound to human CLDN 18.2, and includes a light-chain variable region (VL) and / or a heavy-chain variable region (VH); and the CLDN 18.2-resistant antibody correspondingly contains at least one specific complementary determining region (CDR) sequence or a mutant sequence of the specific complementary determining region (CDR) sequence in the light-chain variable region (VL) and / or a heavy-chain variable region (VH), and binding of the antibody to CLDN 18.2 is maintained or improved through the mutation. The invention also discloses a ADC-containing pharmaceutical composition and a preparation method and application of ADC. The antibody drug conjugate of the antibody has a large security window and low toxic and side effects, and provides more specific,more effective and better treatment option for tumor patients.
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Description

technical field

[0001] The present invention relates to the field of biomedicine, in particular to a drug conjugate of an anti-CLDN18.2 antibody and its preparation method and application. Background technique

[0002] Cancer is a great threat to human health and one of the important causes of death in the field of disease. Cancer treatment has undergone various stages of development, such as surgery, chemotherapy, targeted drugs, tumor immunotherapy, and combination therapy, and has made great achievements in recent years. Among the numerous cancer patients, treatment options for cancer patients such as lung cancer, gastric cancer, pancreatic cancer, esophageal cancer, and ovarian cancer remain highly unmet. The treatment methods for these tumors include macromolecular targeted drugs, such as new monoclonal antibodies, and the combination of these monoclonal antibodies and existing tumor immunotherapy methods, including immune checkpoint inhibitors PD-1 and PD-L1 antibodie...

Claims

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