Preparation method of chloroquinaldol

A technology for chloroquinadol and chloroquinadol hydrochloride, applied in the field of medicine, can solve the problems of lack of chloroquinadol product quality research, affecting product stability, efficacy and metabolism, etc., and achieves the effects of easy operation and high stability
CN111116467AActive Publication Date: 2020-05-08BEIJING JINCHENG TAIER PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING JINCHENG TAIER PHARMA CO LTD
Publication Date
2020-05-08

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of chloroquinaldol. The preparation method comprises the following steps: adding water intochloroquinaldol hydrochloride for dissolving, adding a buffer solution under the conditions of light shielding and nitrogen protection, regulating the pH value by using alkali, filtering and refiningthe solution to obtain chloroquinaldol. The method is easy and convenient to operate and suitable for industrial production, the purity of the prepared chloroquinaldol is high and can reach 99.99% orabove, and the stability of the product is high.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of chloroquinaldol. Background technique

[0002] Chlorquinaldol is a broad-spectrum bacteriostatic agent, and its structural formula is as follows:

[0003]

[0004] The relative molecular weight of chloroquinaldol is 228.07, and it has a slightly pungent smell, and it is a yellow needle-like crystal. As early as the 1950s, many European pharmaceutical companies conducted extensive research on it and found that it has anti-microbial pathogen activity such as anti-fungal, trichomonas, bacteria (G+ and G-), chlamydia and mycoplasma.

[0005] Chloroquinaldol was first developed and produced by Theramex Pharmaceutical Factory in Monaco. The disclosed synthetic method is to use 8-hydroxy-2-methylquinoline as a raw material, use 20% hydrochloric acid as a solvent, and undergo one-step chlorination under the condition of chlorine gas. Synthesize b...

Claims

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