Photoelectric nerve probe with integrated inner metal shielding layer and preparation method thereof

Abstract

The present invention provides a photoelectric nerve probe integrated with an internal metal shielding layer and a preparation method thereof, comprising: an electrophysiological signal recording channel used to conduct nerve electrical signals from electrode points to a collection system; a laser diode power supply channel used to The path used to drive the laser diode at the pad that conducts the pulsed current or voltage signal to the base of the nerve probe; the metal shielding layer is integrated between the electrophysiological signal recording channel and the laser diode power supply channel. The present invention not only has the functions of nerve signal recording and light stimulation, but also the intermediate metal shielding layer integrated in the base of the probe separates the electrophysiological signal recording channel and the power supply channel of the laser diode in layers, so that the electromagnetic interference recorded by the electrophysiological channel Stimulus-following artifacts have a large attenuation, which reduces the contamination of neural action potentials caused by stimulus-following artifacts in optogenetic experiments in animals. The invention adopts MEMS technology and has high reproducibility.

Description

Technical field [0001] The present invention relates to a neuronal signal recording and a stimulating microelectrode in the field of biomedicine engineering, in particular, an optical neurode needle and a preparation method thereof in an integrated internal metal shielding layer. Background technique [0002] In the past few decades, the method of stimulating the brain has enabled people to inspect the function of the brain. In order to further promote the development of neuroscience and study the mechanism of action between a large number of neurons in complex neural networks, selectively is selective to activate or inhibit a particular type of individual neurons. Currently, the use of electrical stimulation is still unable to activate or inhibit specific neurons. Recently, the optical germch is introduced into specific cells to enable it to generate potential responses to light stimuli, which makes neurogens research to be revolutionized. Use the appropriate wavelength to excit...

AI Technical Summary

Problems solved by technology

In 2015, Fan Wu, Euisik Yoon and others proposed to grow gallium nitride (GaN) layer on the chip, and form the miniature LED directly on the tip of the probe to form a photoelectric neural probe for defiberization. However, due to the working time of the miniature LED and the organization If the distance is too close, the temperature rise caused by light irradiation will cause tissue overheating and affect normal nerve electrophysiological activities

The disadvantage of this method is the close distance between the power supply line of the laser diode and the recording channel, which can produce artifacts of stimulus locking caused by electromagnetic interference (EMI) coupling, contaminating the recording of normal neural action potentials

Images