Automatic synthesis device for [<18>F]AlF aluminum fluoride labeled radiopharmaceuticals

Abstract

The invention discloses an automatic synthesis device for [<18F>]AlF aluminum fluoride labeled radiopharmaceuticals, and belongs to the field of nuclear medicine and molecular imaging. The device structurally comprises an injection pump, a one-way n distribution valve, a two-position ten-way valve, a two-position three-way valve, a product purification solid-phase extraction column, a micro anionexchange column for <18>F concentration, a waste liquid bottle, a product collection bottle and a heating marking assembly, and is used for realizing the processes of <18>F ion concentration leaching,heating labeling, product purification and the like. Compared with devices in the prior art, the automatic radiopharmaceutical synthesis device has the advantages of realization of efficient and automatic synthesis of [<18>F]AlF type positron imaging agents, great improvement of the reproducibility and reliability of radiopharmaceutical production, great reduction of the radiation dosage of operators, and provision of equipment guarantee for research, development and clinical conversion of positron imaging agents.

Description

Technical field [0001] The present invention relates to the field of nuclear medicine and molecular imaging, and specifically provides a method for [ 18 F]AlF aluminum fluoride-labeled radiopharmaceutical automatic synthesis device, which can realize the precursor molecules containing multidentate bifunctional chelating agent functional groups [ 18 F] AlF aluminum fluoride label is automatically synthesized, and the molecules are water-soluble peptides or small molecules. Background technique [0002] based on[ 18 F]AlF aluminum fluoride radiolabeling strategy has been developed into a new type of positron nuclide labeling technology. This technology has many advantages, such as mild labeling conditions, simple purification process, and can realize the preparation and distribution of multiple patient doses. With clinical routine use 68 Compared with Ga radiolabeled drugs, [ 18 F]AlF positron drugs have more clinical advantages, 18 F has a longer half-life, relative to 68 For Ge-Ga...

AI Technical Summary

Problems solved by technology

The main reasons are as follows: 1. The complex piping system of the commercial synthesizer increases the liquid residue of the solvent during the transfer process; 2. The transfer method and control accuracy of the reagent solution are not suitable for the microliter-level labeling reaction system; 3. Usually The reaction vessel of a commercial synthesizer is relatively large, and the heating reaction of a small volume of reaction solution may affect the composition of the entire system, such as pH value, the proportion of organic solvents, etc., and these factors may cause the labeling yield to decrease

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