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Solid self-microemulsion microcapsule containing astaxanthin and quercetin, preparation method and application thereof

A technology of self-microemulsion and quercetin, which is applied in the field of carrier systems in functional foods, can solve the problems of low bioavailability in vivo, poor water solubility of astaxanthin, and low stability of liquid self-microemulsion preparations, and achieve improved solubility And anti-oxidation, dissolution rate and bioavailability improvement, the effect of improving bioavailability

Inactive Publication Date: 2020-06-12
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In view of the technical problems of poor water solubility of astaxanthin, low stability of liquid self-microemulsion preparations and low bioavailability in vivo in the prior art, the present invention intends to design two aspects of P protein and drug-loading system from the perspective of affecting bioavailability. Starting to consider and design a rational P protein inhibitor-astaxanthin delivery system to improve its application properties

Method used

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  • Solid self-microemulsion microcapsule containing astaxanthin and quercetin, preparation method and application thereof
  • Solid self-microemulsion microcapsule containing astaxanthin and quercetin, preparation method and application thereof
  • Solid self-microemulsion microcapsule containing astaxanthin and quercetin, preparation method and application thereof

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preparation example Construction

[0059] The preparation method of the solid self-microemulsion microcapsule containing astaxanthin and quercetin of the present invention comprises the following steps:

[0060] (1) Preparation of blank self-microemulsion: Weigh 20-40 parts of oil phase, 50-100 parts of emulsifier and 30-60 parts of co-emulsifier, and mix thoroughly with electromagnetic stirring to obtain a transparent yellowish blank self-microemulsion ;

[0061] (2) Preparation of quercetin self-microemulsion: Weigh 100-250 parts of quercetin into the above-mentioned blank self-microemulsion, mix evenly under constant temperature magnetic stirring at 60°C, and obtain brown-yellow homogeneous quercetin Self-microemulsion;

[0062] (3) Preparation of astaxanthin-quercetin self-microemulsion: Weigh 1-5 parts of astaxanthin and add it into quercetin self-microemulsion, and stir magnetically at a constant temperature of 37°C to obtain a uniform orange-red oily liquid containing shrimp Self-microemulsion of penic...

Embodiment 1

[0076] The preparation method of the solid self-microemulsion microcapsule containing astaxanthin and quercetin of the present embodiment comprises the following steps:

[0077] (1), at 25°C, weigh 20 parts of castor oil (as oil phase), 20 parts of Tween 80 (as emulsifier), 30 parts of Cremophor RH 40 (as emulsifier) ​​and 30 parts of PEG 400 (as emulsifier) co-emulsifier), at 60°C, with 400r / min electromagnetic stirring, uniformly and fully mixed for 30min, to obtain a light yellow, clear and uniform blank self-microemulsion.

[0078] (2) After weighing 10 parts of blank self-microemulsion, add 100 parts of quercetin several times in a small amount to the system, and mix evenly under constant temperature magnetic stirring at 60°C to obtain a yellow, clear, uniform, relatively viscous quercetin self-microemulsion milk.

[0079] (3) After cooling to room temperature, add 3 parts of astaxanthin into quercetin self-microemulsion, and under constant temperature magnetic stirring ...

Embodiment 2

[0083] The preparation method of the solid self-microemulsion microcapsule containing astaxanthin and quercetin of the present embodiment comprises the following steps:

[0084] (1), at 25°C, weigh 20 parts of castor oil (as oil phase), 20 parts of Tween 80 (as emulsifier), 30 parts of Cremophor RH 40 (as emulsifier) ​​and 30 parts of Transcutol HP (as emulsifier) co-emulsifier), at 60°C, with 400r / min electromagnetic stirring, uniformly and fully mixed for 35min, to obtain a blank self-microemulsion with light yellow, clear and uniform, good fluidity.

[0085] (2) After weighing 10 parts of blank self-microemulsion, add 100 parts of quercetin several times in a small amount to the system, and uniformly mix under constant temperature magnetic stirring at 60° C. to obtain yellow and clear quercetin self-microemulsion.

[0086] (3) After cooling to room temperature, add 3 parts of astaxanthin into quercetin self-microemulsion, and under constant temperature magnetic stirring at ...

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Abstract

The invention provides a solid self-microemulsion microcapsule containing astaxanthin and quercetin, a preparation method and application thereof. The self-microemulsion microcapsule comprises astaxanthin, quercetin, an oil phase, an emulsifier, a co-emulsifier and a solid adsorbent. According to the invention, starting from the design angle of a drug-loaded delivery system, astaxanthin and quercetin are combined to prepare a solid self-microemulsion microcapsule system, so that the traditional single carrying system of astaxanthin is broken through; the quercetin has high safety, and can inhibit the excretion effect of P-gp on medicine, so that the activity of drug metabolic enzyme CYP3A4 and drug transporter P-glycoprotein is inhibited, the bioavailability is improved, the solubility ofthe astaxanthin is improved, the quercetin and the astaxanthin can be compounded to play a role, the stability can be improved, and the oxidation resistance of the astaxanthin is not influenced; and the solid self-microemulsion microcapsule has the advantages of liquid self-microemulsion and a solid preparation, so that the dissolution rate and the bioavailability of the medicine are improved.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in functional foods, and specifically relates to a solid self-microemulsion microcapsule containing astaxanthin and quercetin, a preparation method and application thereof. Background technique [0002] Astaxanthin is currently the strongest antioxidant. Recent studies have shown that astaxanthin can prevent and treat cardiovascular diseases, lower blood pressure, prevent and treat atherosclerosis, protect the nervous system, relieve inflammation, prevent and treat cancer, and treat liver diseases. It has various pharmacological activities, such as injury reduction, obesity reduction, prevention and treatment of diabetes, skin protection, vision protection, sports injury reduction and immunity enhancement. Astaxanthin is also the only carotenoid found so far that can penetrate the blood-brain and blood-retinal barriers, and can have a positive impact on the central nervous system and brain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A23L33/105A23P10/35A61K31/122A61K47/22A61K9/50A61K9/107A61K47/02A61K47/26A61P9/00A61P9/12A61P9/10A61P25/00A61P29/00A61P35/00A61P1/16A61P3/04A61P3/10A61P17/00A61P27/02A61P37/04
CPCA23L33/10A23L33/105A23P10/35A61K31/122A61K47/22A61K9/5031A61K9/1075A61K47/02A61K47/26A61P9/00A61P9/12A61P9/10A61P25/00A61P29/00A61P35/00A61P1/16A61P3/04A61P3/10A61P17/00A61P27/02A61P37/04A23V2002/00A23V2200/222A23V2200/30A23V2200/308A23V2200/326A23V2250/2042A23V2250/21168A23V2250/5022A23V2250/5028A23V2250/51084A23V2250/6418
Inventor 张朝燕周滢李学艳王君文黄慧
Owner SHANGHAI OCEAN UNIV
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