Method for improving diabetes mellitus by dental pulp mesenchymal stem cells

A stem cell and diabetes technology, applied in the field of cell therapy, can solve problems such as unsatisfactory treatment effect, large side effects, and elevated blood sugar, and achieve the effects of strong immune regulation, lowering blood sugar, and improving insulin secretion.

Pending Publication Date: 2020-06-16
卡替(上海)生物技术有限公司
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. A variety of endocrine diseases: such as acromegaly, Cushing's syndrome, hyperthyroidism, pheochromocytoma, and glucagonoma can cause secondary diabetes. In addition to elevated blood sugar, there are other characteristic manifestations. Not difficult to identify
Howe

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be described in detail below in conjunction with specific embodiments.

[0018] The invention discloses a method for improving diabetes by dental pulp mesenchymal stem cells. The method for improving diabetes by dental pulp mesenchymal stem cells is as follows: firstly, dental pulp mesenchymal stem cells are prepared, and deciduous teeth need to be extracted by a dentist. , the tooth is transported to the cell preparation center in a refrigerated state through cold chain transportation, and then the tooth is cut open in the laboratory under GMP conditions to extract the dental pulp tissue, and the stem cells in the dental pulp are extracted; the extracted dental pulp stem cells Cultured in a culture flask for subculture and expansion, and finally passed the identification and detection of dental pulp mesenchymal stem cells, and the cells that meet the identification conditions are dental pulp mesenchymal stem cells; the prepared dental pulp mes...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for improving diabetes mellitus by dental pulp mesenchymal stem cells. The method comprises the following steps: firstly, preparing dental pulp mesenchymal stem cells,wherein pulling out deciduous teeth by a dentist, transporting the teeth to a cell preparation center in a cold storage state through cold chain transportation, then cutting the teeth open in a laboratory under a GMP condition to extract dental pulp tissues in the teeth, and extracting stem cells in dental pulp; culturing the extracted dental pulp stem cells in a culture bottle for passage and amplification; carrying out reinfusion of the prepared dental pulp mesenchymal stem cells into the body of a diabetic patient through intravenous injection, wherein 500,000-700,000 units/kg are injectedonce every 20 days, the stem cells are injected for 3-4 times in total, the use effect of the patient is continuously observed, and whether the treatment needs to be continuously adopted for improvement or not is subsequently determined. The pancreas islet tissue proliferation and regeneration are promoted, insulin secretion is improved, blood sugar is reduced, immune factor disorder is corrected, and inflammation is relieved. The exfoliated deciduous tooth stem cells may be used to ameliorate type 2 diabetes and type 1 diabetes.

Description

technical field [0001] The invention belongs to the technical field of cell therapy, and in particular relates to a method for improving diabetes by dental pulp mesenchymal stem cells. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia caused by defective insulin secretion or its biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. The etiology of diabetes has: 1. Genetic factors: both type 1 and type 2 diabetes have obvious genetic heterogeneity, diabetes has a family tendency, and 1 / 4 to 1 / 2 of the patients have a family history of diabetes. Clinically, there are at least 60 genetic syndromes that can be associated with diabetes. Multiple DNA sites are involved in the pathogenesis of type 1 diabetes, among which the polymorphism of the DQ site in the HLA antigen gene is m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K35/28A61P3/10C12N5/0775
CPCA61K35/28A61P3/10C12N5/0664C12N2509/00
Inventor 李军
Owner 卡替(上海)生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap