Method for improving diabetes mellitus by dental pulp mesenchymal stem cells

Abstract

The invention discloses a method for improving diabetes mellitus by dental pulp mesenchymal stem cells. The method comprises the following steps: firstly, preparing dental pulp mesenchymal stem cells,wherein pulling out deciduous teeth by a dentist, transporting the teeth to a cell preparation center in a cold storage state through cold chain transportation, then cutting the teeth open in a laboratory under a GMP condition to extract dental pulp tissues in the teeth, and extracting stem cells in dental pulp; culturing the extracted dental pulp stem cells in a culture bottle for passage and amplification; carrying out reinfusion of the prepared dental pulp mesenchymal stem cells into the body of a diabetic patient through intravenous injection, wherein 500,000-700,000 units / kg are injectedonce every 20 days, the stem cells are injected for 3-4 times in total, the use effect of the patient is continuously observed, and whether the treatment needs to be continuously adopted for improvement or not is subsequently determined. The pancreas islet tissue proliferation and regeneration are promoted, insulin secretion is improved, blood sugar is reduced, immune factor disorder is corrected, and inflammation is relieved. The exfoliated deciduous tooth stem cells may be used to ameliorate type 2 diabetes and type 1 diabetes.

Description

technical field [0001] The invention belongs to the technical field of cell therapy, and in particular relates to a method for improving diabetes by dental pulp mesenchymal stem cells. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia caused by defective insulin secretion or its biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. The etiology of diabetes has: 1. Genetic factors: both type 1 and type 2 diabetes have obvious genetic heterogeneity, diabetes has a family tendency, and 1 / 4 to 1 / 2 of the patients have a family history of diabetes. Clinically, there are at least 60 genetic syndromes that can be associated with diabetes. Multiple DNA sites are involved in the pathogenesis of type 1 diabetes, among which the polymorphism of the DQ site in the HLA antigen gene is m...

AI Technical Summary

Problems solved by technology

4. A variety of endocrine diseases: such as acromegaly, Cushing's syndrome, hyperthyroidism, pheochromocytoma, and glucagonoma can cause secondary diabetes. In addition to elevated blood sugar, there are other characteristic manifestations. Not difficult to identify

However, these treatment methods in the prior art either have relatively large side effects on the body or have unsatisfactory treatment effects. Therefore, a new treatment method needs to be developed for diabetic patients to improve the quality of life of diabetic patients.