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Application of Haihong rice skin in preparation of drug or preparation against despair and abandonment behavior

A technology of sea red rice skin and medicine, which is applied in the field of medicine, can solve the problems of death, acute poisoning, difficulty, etc., and achieve the effect of activation improvement, no toxic side effects, and lack of improvement

Inactive Publication Date: 2020-06-26
SHENZHEN INST OF GUANGDONG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Monoamine reuptake inhibitors are mainly used, such as bupropion, duloxetine, fluoxetine, etc., but these drugs can cause severe cardiovascular problems such as tachycardia, drowsiness, constipation, dysuria, and urinary retention. Side effects, and overdose can cause acute poisoning or even death

Method used

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  • Application of Haihong rice skin in preparation of drug or preparation against despair and abandonment behavior
  • Application of Haihong rice skin in preparation of drug or preparation against despair and abandonment behavior
  • Application of Haihong rice skin in preparation of drug or preparation against despair and abandonment behavior

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 Tail Suspension Behavioral Experiment

[0061] 1. Experimental method

[0062] Use non-adhesive glue to suspend 1 / 3 of the tip of the tail of the mouse on the tail-suspension device, so that its head is facing the camera and about 10 cm above the ground, and record the desperate behavior of the mouse within 5 minutes, and record the despair of the mouse within 5 minutes Immobility time (s). The immobility time was judged as the mouse stopped struggling and was in an upside-down hanging state as standing still.

[0063] 2. Experimental results

[0064] Such as figure 2 As shown, the results showed that: compared with the control group, the immobility time of the mice in the CUMS group was up-regulated by 29.44%, indicating that the mice were more likely to give up their lives in despair; The immobility time was reduced by 22.79%, indicating that Haihong 12 Mipi had a significant improvement effect on CUMS-induced abandonment and despair.

Embodiment 2

[0065] Example 2 Detection of gene expression by fluorescent quantitative PCR

[0066] 1. Experimental method

[0067] Total RNA was extracted and purified from brain tissue by Trizol method. cDNA was synthesized using a reverse transcription kit. Real-time PCR total reaction system (SYBR Green PCR mixture) total 12μl (6uL Premix Ex TaqII, 0.24uL upstream primer, 0.24uL downstream primer, 2uL DNA template, 3.52uL DEPC-treated water) were mixed into the white 8-strip tube. The program of PCR is a 2-step method, starting at 95°C for 3 min, denaturation at 95°C for 5 s, annealing at 60°C for 30 s, and single fluorescence detection (40 cycles). Detection of gene expression changes in microglia and inflammasomes in the hippocampus of the mouse brain.

[0068] 2. Experimental results

[0069] (1) Changes in gene expression of microglial subtypes M1 (Iba-1) and M2 (CD206) in the hippocampus

[0070] Such as image 3 As shown, the results showed that: compared with the control...

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to an application of Haihong rice skin in preparation of a drug or preparation against despair and abandonment behavior. The Haihong rice skin has a significant improvement effect on the CUMS-induced despair and abandonment behavior by regulating and controlling the activity of inflammasome and microglia in the hippocampus of mice and improving neurotrophic factors, and in addition, the Haihong rice skin is naturally non-toxic and free of any toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of sea red rice bark in the preparation of anti-desperate drugs or preparations. Background technique [0002] It is well known that life stress, physical illness or psychological stress are the triggers of many mental illnesses, including depression, despair and giving up. Professor Willer successfully confirmed in 1987 that chronic unpredictable stress can significantly cause behaviors such as despair, abandonment, anhedonia and anxiety in animals, and it has been recognized internationally. [0003] Microglia are macrophages in the brain, which have corresponding inflammatory factor receptors on their surface, and can synthesize and secrete a variety of inflammatory factors. At present, the hot research directions in the world are the central inflammatory response regulated by microglia and the central nervous protection regulated by astrocyt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P25/00A23L33/00A23K10/30A23K20/00A61K131/00
CPCA23V2002/00A61K36/899A23K10/30A23K20/00A23L33/00A61P25/00A23V2200/322
Inventor 宋采李晓红张永平张才
Owner SHENZHEN INST OF GUANGDONG OCEAN UNIV