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Method for extracting framycetin sulphate from neomycin sulphate

A technology of neomycin sulfate and sulfuric acid, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of complex detection methods, small adsorption capacity, high cost, etc., to reduce secondary pollution and improve The effect of low yield and low production cost

Inactive Publication Date: 2020-06-26
吕志洪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But there are many deficiencies in the preparation method of above-mentioned francidine sulfate, and production process is complicated, needs special detection equipment, and detection method is complicated
For example, the type of resin used has small adsorption capacity, low analytical yield, large consumption of raw materials, and high cost
The crystallization process uses methanol as a solvent for precipitation, which is not only costly, but also pollutes the environment due to the discharge of methanol, and the residual content of organic solvents in the prepared product is relatively high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The embodiment of the present invention provides a method for extracting francidine sulfate from neomycin sulfate, which consists of the following steps:

[0030] S1, after dissolving the concentrated neomycin sulfate raw powder with purified water of 20-40 times the weight of the raw powder, obtain the neomycin sulfate concentrated solution, add the chromatographic resin of model HZ001 and adsorb for 3-4h under stirring conditions, Wherein the mass volume ratio of neomycin sulfate powder and chromatography resin is 1:5, until the chromatography resin is saturated.

[0031] S2, wash the saturated chromatographic resin in S1 with 0.1mol / L ammoniacal liquor, and control the flow rate of ammoniacal liquor to be 0.1 times the volume of chromatographic resin per hour (the flow rate of ammoniacal liquor used in S3 is the same), to the washing amount of ammoniacal liquor 3-4 times the volume of the chromatography resin to wash away neomycin C and other impurities.

[0032] S3...

Embodiment 2

[0039] The embodiment of the present invention provides a method for extracting francidine sulfate from neomycin sulfate, which consists of the following steps:

[0040] S1, after dissolving the concentrated neomycin sulfate raw powder with purified water of 20-40 times the weight of the raw powder, obtain the neomycin sulfate concentrated solution, add the chromatographic resin whose model is HZ201 and adsorb under stirring conditions for 3-4h, Wherein the mass volume ratio of neomycin sulfate powder and chromatography resin is 1:5, until the chromatography resin is saturated.

[0041] S2, wash the saturated chromatographic resin in S1 with 0.3mol / L ammoniacal liquor, and control the flow rate of ammoniacal liquor to be 0.2 times the volume of chromatographic resin per hour (the flow rate of ammoniacal liquor used in S3 is the same), to the washing amount of ammoniacal liquor 3-4 times the volume of the chromatography resin to wash away neomycin C and other impurities.

[00...

Embodiment 3

[0049] The embodiment of the present invention provides a method for extracting francidine sulfate from neomycin sulfate, which consists of the following steps:

[0050] S1. After dissolving the concentrated neomycin sulfate raw powder with purified water of 20-40 times the weight of the raw powder, obtain the neomycin sulfate concentrated solution, add a chromatographic resin of type LK20 and adsorb for 3-4h under stirring conditions, Wherein the mass volume ratio of neomycin sulfate powder and chromatography resin is 1:5, until the chromatography resin is saturated.

[0051]S2, wash the saturated chromatographic resin in S1 with 0.5mol / L ammoniacal liquor, and control the flow rate of ammoniacal liquor to be 0.1 times the volume of chromatographic resin per hour (the flow rate of ammoniacal liquor used in S3 is the same), to the washing amount of ammoniacal liquor 3-4 times the volume of the chromatography resin to wash away neomycin C and other impurities.

[0052] S3, the...

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Abstract

The invention provides a method for extracting framycetin sulphate from neomycin sulphate. The method comprises the following steps of S1, dissolving concentrated neomycin sulphate raw powder with purified water to obtain a neomycin sulphate concentrated solution, and adding chromatographic resin for adsorption; S2, washing the saturated chromatographic resin in the step S1 with ammonia water; S3,eluting the treated chromatographic resin in the step S2 with ammonia water to obtain an eluate; S4, concentrating the eluate with a thin-film evaporator to obtain a concentrated solution; S5, carrying out salt conversion operation on sulfuric acid in the concentrated solution; S6, adding activated carbon into the concentrated solution subjected to salt conversion, and performing decolorization and pressing filtration to obtain a decolorized solution; and S7, spray-drying the decolorized solution at 135 DEG C to obtain the finished framycetin sulphate. According to the method, spray drying isadopted to replace crystallization operation, and no organic solvent is used, so that no organic solvent residues exist in the formed finished framycetin sulphate, the yield and the product quality of the finished framycetin sulphate are improved, the production cost is low, and no organic matter is generated after waste liquid is discharged.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, in particular to a method for extracting francidine sulfate from neomycin sulfate. Background technique [0002] Francidine sulfate (neomycin sulfate B) is an aminoglycoside antibiotic isolated from the finished powder of neomycin sulfate. It has good antibacterial effect on Staphylococcus aureus and Corynebacterium. Enterobacteriaceae such as Escherichia, Klebsiella, and Proteus also have good effects, overcome the side effects of neomycin sulfate, and can be made into injections, powders, and ointments. [0003] The commonly used preparation method of francidine sulfate is to separate and obtain the finished powder of neomycin sulfate. Neomycin sulfate is composed of neomycin sulfate B, neomycin sulfate C and some impurities, wherein neomycin sulfate B and neomycin sulfate C are stereoisomers each other, and the content of neomycin sulfate B is 75-82%, the content of neomycin sulf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H15/232
CPCC07H1/06C07H15/232
Inventor 吕志洪
Owner 吕志洪
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