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Immunologic adjuvant composition as well as preparation method and application thereof

A vaccine composition and composition technology, applied in biochemical equipment and methods, vaccines, microorganisms, etc., to achieve good stability, simple preparation process, and remarkable immune effect

Pending Publication Date: 2020-06-30
LUOYANG SEIWEI BIOTECHNOLOGIES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many adjuvants disclosed in the prior art, how to solve these three problems at the same time is still a difficult problem for those skilled in the art

Method used

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  • Immunologic adjuvant composition as well as preparation method and application thereof
  • Immunologic adjuvant composition as well as preparation method and application thereof
  • Immunologic adjuvant composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 prepares carbomer solution

[0058] Add 1 g of Carbomer 934 to 50 ml of water, stir to dissolve, then add 1.5 g of sodium chloride solution, adjust the pH to 7.0 with sodium hydroxide solution, and sterilize it by autoclaving for later use, with a content of 2% w / v.

Embodiment 2

[0059] Embodiment 2 prepares lecithin ethanol solution

[0060] Add 5 g of lecithin (PC90, produced by Jiangsu Manshi Biotechnology Co., Ltd.) into 100 ml of ethanol, stir to dissolve it, and filter it through a 0.22-micron filter membrane for later use, with a content of 5% w / v.

Embodiment 3

[0061] Embodiment 3 prepares ginsenoside solution

[0062] Add 1 g of ginseng stem and leaf saponins (containing 76.7% of total saponins, produced by Jilin Hongjiu Biotechnology Co., Ltd.) into 100 ml of water, stir to dissolve, filter with a 0.22 micron membrane filter, and set aside, with a content of 1% w / v.

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Abstract

The invention provides an adjuvant composition. The adjuvant composition comprises 0.2-0.5%w / v of carbomer, 0.1-0.5%w / v of lecithin and 0.03-0.2%w / v of ginsenoside. The adjuvant composition of the invention can maintain long-term clarification and / or stability of vaccine, the inactivated antigen and subunit antigen in the composition can be effectively excited to produce high-titer antibodies forimplementing immunoprotection. The inactivated vaccine or subunit vaccine prepared by the adjuvant composition of the invention can be used as a diluent for freeze-dried live virus antigens, which hasno toxic and killing effects on live virus antigens.

Description

technical field [0001] The invention belongs to the field of medical preparations, and relates to immune adjuvant composition, its preparation method and application. Background technique [0002] "Adjuvant" means a substance that enhances the humoral or cellular immune response to an antigen. Adjuvants are generally used to achieve two goals: controlled release of antigen from the injection site and stimulation of the immune system. Because adjuvants containing white oil for injection used in animals have strong side effects, people have developed water-based adjuvants, such as polyacrylic acid adjuvants represented by trade name Carbomer and model 934, including seppic’s commercial GEL01 adjuvant. However, this type of aqueous adjuvant is only effective for some antigens, and the effect on other antigens is poor, and the polyacrylic acid solution is prone to particle size when placed in an isotonic solution for a long time, forming stratification and precipitation, thereb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/12A61K39/02A61K39/187A61K39/245A61P31/20A61P31/04A61P31/14A61P31/22
CPCA61K39/39A61K39/12A61K39/0241A61P31/20A61P31/04A61P31/14A61P31/22A61K2039/55511A61K2039/55577A61K2039/5252A61K2039/5258C12N2750/10034C12N2770/24334C12N2770/10034C12N2710/16734A61K2039/5254C12N2710/12034A61K2039/552A61K39/187A61K39/245
Inventor 田克恭刘永梅张许科
Owner LUOYANG SEIWEI BIOTECHNOLOGIES CO LTD
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