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Light sensitive material/calcium alginate core-shell nanocapsule dispersoid and preparation method thereof

A technology of calcium alginate and nanocapsules, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of complex preparation methods, high product costs, and expensive liposomes, and achieve the goal of preparing The effect of simple process and high wrapping rate

Active Publication Date: 2020-07-03
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liposomal encapsulation of vitamin A palmitate can promote the absorption of vitamin A palmitate, and the content of vitamin A palmitate is between 1% and 15%, but the price of liposome is relatively expensive, and the preparation method is relatively complicated, and the obtained Product cost is higher

Method used

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  • Light sensitive material/calcium alginate core-shell nanocapsule dispersoid and preparation method thereof
  • Light sensitive material/calcium alginate core-shell nanocapsule dispersoid and preparation method thereof
  • Light sensitive material/calcium alginate core-shell nanocapsule dispersoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Dissolve 0.4g SA (sodium alginate) and 0.4g PVA (emulsifier) ​​in 40mL water to form SA aqueous solution;

[0076] Dissolve 7.5g VE in 20mL mineral oil to form VE solution (vitamin E solution);

[0077] Pour the vitamin E solution into the SA aqueous solution and disperse it with a disperser (IKA Ultra Turrax T-18, 10,000r / min, 5min) to obtain a VE emulsion;

[0078] Dissolve 0.06 g of calcium chloride in 8 mL of water, add dropwise to the VE emulsion, and stir for 15 min to obtain a vitamin E / calcium alginate capsule dispersion.

[0079] Dynamic light scattering measurements showed that the vitamin E / calcium alginate microcapsules had a particle size of 1126nm and a PDI of 0.258. Ultraviolet spectrophotometer measurement shows that the encapsulation rate of vitamin E is 95%. The optical microscope image of the obtained vitamin E / calcium alginate capsules is as figure 2 As shown, the core-shell capsules are uniform in size. Vitamin E encapsulated in calcium alginat...

Embodiment 2

[0081] Dissolve 0.4g SA (sodium alginate) and 2g Tween 20 (emulsifier) ​​in 40mL water to form SA aqueous solution;

[0082] Dissolve 7.5g of VE in 20mL of mineral oil to form a VE solution;

[0083] Pour the vitamin E solution into the SA aqueous solution, disperse it with a disperser (IKA Ultra Turrax T-18) for 5 minutes, and the shear rate is 10,000r / min, and then use a high-pressure homogenizer (Avestin EmulsiFlex C-5) to homogenize for 10 minutes Get VE emulsion;

[0084] Dissolve 0.06 g of calcium chloride in 8 mL of water, add dropwise to the VE emulsion, and stir for 15 min to obtain a vitamin E / calcium alginate capsule dispersion.

[0085] The dynamic light scattering test results are as follows Figure 5 As shown, the test results show that the vitamin E / calcium alginate nanocapsules have a particle size of 348nm and a PDI of 0.159. Ultraviolet spectrophotometer measurement shows that the encapsulation rate of vitamin E is 94%. The transmission electron microscop...

Embodiment 3

[0087] Dissolve 0.4g SA (sodium alginate) and 4g Tween 20 (emulsifier) ​​in 40mL water to form SA aqueous solution;

[0088] Dissolve 7.5g of VE in 20mL of mineral oil to form a VE solution;

[0089] Pour the vitamin E solution into the SA aqueous solution, disperse it with a disperser (IKA Ultra Turrax T-18) for 5 minutes, and the shear rate is 10,000r / min, and then use a high-pressure homogenizer (Avestin EmulsiFlex C-5) to homogenize for 10 minutes Get VE emulsion;

[0090] Dissolve 0.06 g of calcium chloride in 8 mL of water, add dropwise to the VE emulsion, and stir for 15 min to obtain a vitamin E / calcium alginate capsule dispersion.

[0091] Dynamic light scattering tests such as Figure 5 As shown, the test results show that the vitamin E / calcium alginate nanocapsules have a particle size of 210nm and a PDI of 0.118. Ultraviolet spectrophotometer measurement shows that the encapsulation rate of vitamin E is 96%. Vitamin E encapsulated in calcium alginate nanocapsul...

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Abstract

The invention provides a light sensitive material / calcium alginate core-shell nanocapsule dispersoid and a preparation method thereof. By the method, light sensitive materials can be made into the light sensitive material / calcium alginate core-shell nanocapsule dispersoid, and the light sensitive materials can be subjected to stabilization and controlled release, and have the characteristics of being simple in technology and safe and reliable. The preparation method provided by the invention comprises the following steps of (1) adding an oil phase solution to an aqueous phase solution, and performing emulsifying to obtain emulsion, wherein the oil phase solution contains the light sensitive materials; or directly adding purely light sensitive materials to the aqueous phase solution, and performing emulsifying so as to obtain the emulsion, wherein the aqueous phase solution is obtained through enabling sodium alginate and / or modified sodium alginate and an emulsifying agent to dissolvein water, and is used as a wall material solution; and (2) adding a curing agent aqueous solution to the emulsion, and performing gel coagulation for obtaining shells of the sodium alginate so as to obtain the light sensitive material / calcium alginate core-shell nanocapsule dispersoid, wherein the curing agent aqueous solution is selected from calcium lactate and / or a calcium chloride aqueous solution.

Description

technical field [0001] The invention discloses a preparation method for a stable light-sensitive material, which can prevent the degradation of the light-sensitive material. Background technique [0002] Active substances such as vitamins, amino acids, enzymes, and hormones are often added to personal care products to nourish the skin and resist aging; at the same time, a certain amount of sunscreen is also added to protect the skin from ultraviolet rays. However, some active ingredients are more sensitive to light and will be inactivated when exposed to light, such as vitamin E and so on. Vitamin E is stable to acid and heat, but it will be destroyed when exposed to ultraviolet rays. When it is directly added to cosmetics, its antioxidant effect is very limited. In addition, vitamin E is an oil-soluble viscous liquid, and the skin feels sticky. Improving the stability of oil-soluble active substances so that they can be added to water-based products is a very important re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/67A61K8/37A61K8/27A61K8/11A61Q17/04A61Q19/00
CPCA61K8/733A61K8/27A61K8/678A61K8/37A61K8/11A61Q19/00A61Q17/04A61K2800/56A61K2800/413Y02A50/30
Inventor 张川姚丹
Owner WANHUA CHEM GRP CO LTD
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