Fluid haemostatic adhesive and preparation method thereof

A fluid and composite gel technology, applied in the medical field, can solve problems such as poor adhesion, unsuitable wounds with high blood flow, and no fluidity

Active Publication Date: 2020-07-07
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Chinese patent CN105536029A discloses a preparation method of chitosan porous hemostatic sponge. The hemostatic product has good hemostasis, antibacterial, anti-inflammatory, and wound healing effects. However, this type of single-component hemostatic product is easy to adhere to the wound. Long time, with certain limitations
[0004] Chinese patent CN104189941A discloses a chitosan gel hemostatic material and its preparation method, which is obtained by compounding chitosan, cross-linking agent and thrombin, which can quickly stop bleeding in vivo and promote wound healing, but the invention is dry coagulation Glue state, after absorbing the moisture in the wound, the adhesion becomes poor, and there is no fluidity, which is not conducive to sealing the wound
In addition, Floseal and Surgiflo currently on the market are hemostatic compositions containing thrombin, which are relatively effective hemostatic products, but their adhesion is poor, and they are not suitable for wounds with high blood flow. The two components can only be administered after mixing, which brings great inconvenience to clinical rapid hemostasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Embodiment 1: the preparation of cross-linked carboxymethyl chitosan

[0089] Weigh 0.8g sodium hydroxide, dissolve in 185mL water to obtain 0.1mol / L sodium hydroxide solution; weigh 15.0g carboxymethyl chitosan (deacetylation degree 90.1%, molecular weight 20kDa), dissolve in the above-mentioned hydroxide In the sodium solution, stir for 1 h to obtain a carboxymethyl chitosan solution with a mass fraction of 7.5%; add 0.075 g of 1,4-butanediol diglycidyl ether to the carboxymethyl chitosan solution, and stir for 0.5 h; Adjust the reaction temperature to 20-60°C, and let it stand for 20 hours to obtain cross-linked carboxymethyl chitosan; add 200 mL of 0.1mol / L hydrochloric acid solution to the cross-linked carboxymethyl chitosan to carry out acid-base neutralization reaction, And use 0.1mol / L hydrochloric acid solution to adjust the pH value of cross-linked carboxymethyl chitosan to about 6.8-7.6; transfer the neutralized cross-linked carboxymethyl chitosan to a homoge...

Embodiment 2

[0090] Embodiment 2: the preparation of cross-linked carboxymethyl chitosan

[0091] Weigh 0.8g sodium hydroxide, dissolve in 185mL water to obtain 0.1mol / L sodium hydroxide solution; weigh 15.0g carboxymethyl chitosan (deacetylation degree 90.1%, molecular weight 20kDa), dissolve in the above-mentioned hydroxide In the sodium solution, stir for 1 h to obtain a carboxymethyl chitosan solution with a mass fraction of 7.5%; add 0.15 g of 1,4-butanediol diglycidyl ether to the carboxymethyl chitosan solution, and stir for 0.5 h; Adjust the reaction temperature to 20-60°C, and let it stand for 20 hours to obtain cross-linked carboxymethyl chitosan; add 200 mL of 0.1mol / L hydrochloric acid solution to the cross-linked carboxymethyl chitosan to carry out acid-base neutralization reaction, And use 0.1mol / L hydrochloric acid solution to adjust the pH value of cross-linked carboxymethyl chitosan to about 6.8-7.6; transfer the neutralized cross-linked carboxymethyl chitosan to a homogen...

Embodiment 3

[0092] Embodiment 3: the preparation of cross-linked gelatin

[0093] Weigh 30.0 g of gelatin particles (particle size is 500 μm, pH is 5.5), dissolve in 570 mL of water, stir for 0.5 h to obtain a gelatin solution with a mass fraction of 5%; adjust the pH of the system to 5.0 with 0.1 mol / L hydrochloric acid solution ~5.5, add 0.3 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride to the gelatin aqueous solution, and continue to use 0.1mol / L hydrochloric acid solution to adjust the pH value of the system to 5.0~ 5.5; Adjust the reaction temperature to 2-10°C and react for 15 hours under stirring to obtain cross-linked gelatin; transfer the reaction solution to a 3L beaker, add 2L of water, react for 30min under stirring, then let stand for 30min, discard the supernatant solution, repeat the above cleaning operation more than 15 times; transfer the gelatin solution to the VFD-1000 freeze dryer of Beijing Boyikang Experimental Instrument Co., Ltd., and freeze-dry for...

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Abstract

The invention provides a fluid haemostatic adhesive and a preparation method thereof. The fluid haemostatic adhesive comprises cross-linked chitosan or a derivative thereof, cross-linked water-solubleprotein or polypeptide, and a lubricating agent. The haemostatic adhesive does not contain blood coagulation factors, is in a flowable ointment shape, has a proper swelling degree, can be directly used without involving any time-consuming reconstruction step, and has the advantages of short haemostatic time, high wound healing speed, convenience and rapidness in use, in-vivo degradability, good biocompatibility and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a fluid hemostatic glue and a preparation method thereof. Background technique [0002] Wound bleeding is unavoidable in daily life. Although minor trauma is not fatal, if the blood loss reaches 30% or more of the total blood volume of the human body in a short period of time, it will be life-threatening. Most of the death cases in emergencies such as wars, natural disasters, and traffic accidents are caused by excessive blood loss. Therefore, in the process of rescuing the injured, local and effective rapid hemostasis is very important. Local hemostasis is the first step in trauma treatment, and effective hemostasis can reduce unnecessary casualties and play a very important role in saving patients' lives. At present, hemostatic gels at home and abroad are mostly in the form of sponge, fiber, powder, film, etc., and are mainly single-component biological hemostatic dressings. Although t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/08A61L24/108A61L24/0031A61L24/0015A61L2400/04A61L2300/236A61L2300/252A61L2400/06A61L2300/418C08L5/08C08L89/00
Inventor 曹加花崔志明李睿智李亦晨
Owner IMEIK TECH DEV CO LTD
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