Application of wheat germ globulin in maintaining respiratory tract cytokine balance

Abstract

The invention discloses application of wheat germ globulin in maintaining respiratory tract cytokine balance, and the related respiratory disease is a model caused by qi deficiency and wind-cold and includes nasal secretion detection cytokine imbalance; the respiratory diseases is a pro-inflammatory factor higher than an anti-inflammatory factor, the measured fever body temperature is greater thanor equal to 37 DEG C, and the manifested symptoms are sneezing and nasal secretion increase; the composition can be prepared into wheat germ globulin oral liquid or other dosage forms, is used as a functional food for preventing cytokine imbalance caused by cold, further provides treatment supplement for epidemic respiratory tract infection, avoids occurrence and development of inflammatory storm, is developed to be suitable for constitution of children, strengthens balance of part of cytokines of respiratory tract, and in combination with more and more prominent problems of respiratory diseases, the effect of balancing respiratory tract cytokines caused by cold can be remarkably improved, and the application prospect is good.

Description

technical field [0001] The invention relates to the application of wheat germ globulin, in particular to the application of wheat germ globulin in maintaining the balance of respiratory tract cytokines, and belongs to the field of biotechnology. Background technique [0002] Wheat Embryo Globulin (WEG) is a small molecular protein extracted from wheat germ. Wheat germ is a traditional medicinal and edible food in my country. "Compendium of Materia Medica" records: "Wheat germ can cure palpitations and insomnia. , Nourish the heart and calm the nerves, nourish the liver qi, relieve diarrhea, lower blood pressure, and invigorate the stomach." The Ming Dynasty medical book "Immunity Class Prescriptions" describes it as "reinforcing deficiency, exempting from plague, and strengthening energy". The protein content in wheat germ is about 30%, mainly composed of albumin and globulin, which is a kind of high-quality plant protein resource, especially globulin is safe and non-toxic t...

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Problems solved by technology

[0005] Respiratory tract infection can cause inflammatory cells to infiltrate into the injury site, activate immune cells to change into an activated state related to redness, etc. Interleukins, interferons, tumor necrosis factor superfamily, chemokines, etc. produced by these immune cells play a role in pain hypersensitivity. TNF and IL-1 family cytokines are common pro-inflammatory factors; anti-inflammatory factors include IL-4 and transforming growth factor-β (TGF- β), they serve as negative feedback regulators to maintain immune balance, and the level of IL-4 in patients with respiratory tract infection decreases. If the balance between pro-inflammatory factors and anti-inflammatory factors is out of balance, especially in severe patients, an inflammatory storm (cell Factor storm), inflammatory storm leads to the failure of various organs; this is why some patients with new coronary pneumonia will die suddenly, because the early onset of such patients is not very dangerous, but it will suddenly accelerate in the later stage, and the patient will soon enter a multi- In the state of organ failure, the reason is that the patient’s body has activated an inflammatory storm. Immunosuppression means that the immune system is low and susceptible to infections such as bacteria, viruses, and fungi. Since there is currently no specific drug, improving self-immunity is the most effective measure to fight infection.

[0006] At present, there is no public report on the anti-respiratory tract infection treatment suitable for low immunity, especially the use of wheat germ globulin to balance the cytokines (pro-inflammatory factors and anti-inflammatory factors) secreted by respiratory infection cells

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