Ester ammonolysis reaction catalyst composition and preparation method of L-menthane carboxamide

A technology of menthamide and catalyst is applied in the field of ester aminolysis reaction catalyst composition, and can solve the problems of severe reaction conditions, racemization, and difficulty in industrialization, and achieve the effects of ensuring optical purity, reducing raw material costs, and reducing environmental protection costs.
CN111393293AActive Publication Date: 2020-07-10WANHUA CHEM GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WANHUA CHEM GRP CO LTD
Publication Date
2020-07-10

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Abstract

The invention discloses an ester ammonolysis reaction catalyst composition and a preparation method of L-menthane carboxamide. The ester ammonolysis reaction catalyst comprises a catalyst and a ligand, wherein the catalyst is cuprous salt CuX, the ligand is a (R)-N, N, N, N-tetraalkyl binaphthylamine compound shown as the specification, wherein R1, R2, R3 and R4 are independently selected from thegroups shown as the specification. Menthyl chloride is used as the starting raw material in the method to react with metal magnesium to prepare menthyl magnesium chloride, then reaction with chloroformate with different substituent groups is carried out to obtain menthyl formate, and then ammonolysis under the catalysis of an ester ammonolysis catalyst composition is conducted to obtain the L-menthane carboxamide. The yield is improved, the production cost is reduced, the optical purity is high, and environmental protection and no wastewater discharge are realized.
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Description

technical field

[0001] The invention relates to a catalyst composition for ester aminolysis reaction, and also relates to a preparation method of cooling agent L-menthol amide. Background technique

[0002] Cooling agents are indispensable additives in people's daily life, and are widely used in the fields of food, daily chemicals, tobacco and medicine. For a long time, L-menthol has been the most familiar traditional cooling agent. L-menthol has the advantages of strong coolness, low threshold value and low price, but it also has some obvious disadvantages, such as strong pungent smell, bitter taste, not obvious cooling effect when the dosage is low, and when the concentration is large, there will be Burning sensation, strong volatility, short action time, etc., these shortcomings limit the application of L-menthol in many fields to a certain extent, especially in chewing gum and some special types of cosmetics. Therefore, people begin to seek more effective cooling agent...

Claims

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