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Raman spectrum-based serum detection system and method

A Raman spectroscopy and detection system technology, applied in the field of spectral analysis, can solve the problems of sample contamination, biological security threats, affecting the authenticity of Raman detection data, etc.

Active Publication Date: 2020-07-14
CHENGDU PANOAI INTELLIGENT TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above extraction and pipetting steps all need to strictly abide by the biosafety regulations. Any small mistakes may cause sample evaporation, sample contamination or sample leakage, which may not only affect the authenticity of Raman detection data, but also lead to biosafety threats.

Method used

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  • Raman spectrum-based serum detection system and method
  • Raman spectrum-based serum detection system and method
  • Raman spectrum-based serum detection system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] As attached figure 1 As shown, a serum detection system based on Raman spectroscopy is characterized in that it includes a Raman detection device and a data processing system connected to the signal. The Raman detection device performs multiple and multi-sampling Raman spectrum sampling on the serum sample, and transmits the collected Raman spectrum data to the data processing system; the data processing system receives the Raman spectrum data and presents the Raman spectrum data The overall data mode is analyzed and processed, and the sampling conditions are adjusted in real time according to the processing results and the serum sample detection is realized. Among them, the sampling conditions include the height of the sampling point and the intensity of the incident light;

[0081] The blood collection tube T that has completed the serum pre-preparation operation is directly used as the sample tube for the serum sample; the serum pre-preparation operation includes the ce...

Embodiment 2

[0108] Compared with the Raman spectroscopy-based serum detection system described in Example 1, the difference in Example 2 is that it provides as attached to the instructions. image 3 The specific structure of another sample displacement mechanism 43 is shown.

[0109] The sample displacement mechanism 43 includes a base 434, a limit platform 435, a supporting platform 431, a controllable telescopic rod 436, and a controllable lifting rod 432; wherein the base 434 has a limit slot in its top plane, and the limit platform 435 is located at the limit In the position groove, the two ends of a plurality of controllable telescopic rods 436 are respectively connected to the limit platform 435 and the inner surface of the limit groove; the supporting platform 431 is used to support and fix the bottom of the blood collection tube T, and the two ends of the controllable lifting rod 432 The supporting platform 431 and the limit platform 435 are respectively connected.

[0110] The system ...

Embodiment 3

[0113] A method flow chart of the serum detection method based on the Raman spectroscopy serum detection system as described in Example 1 or 2 is attached to the instructions Figure 4 , The serum detection method includes the following steps:

[0114] S1. Serum pre-preparation operations for biological serum samples; serum pre-preparation operations include biological blood sample centrifugation, blood cell sedimentation, and sample standing until the upper and lower hierarchical structure of serum and blood clots appear; use blood collection tubes that have completed serum pre-preparation operations T is directly used as the sample tube of the serum sample, where the serum sample corresponds to the supernatant part in the upper and lower layered structure in the blood collection tube;

[0115] S2. After passing the blood collection tube T through the sample passage 41 of the sample loading part 4, it is detachably fixed to the sample displacement mechanism 43;

[0116] S3. Perform ...

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Abstract

The invention belongs to the field of spectral analysis, and particularly relates to a Raman spectrum-based serum detection system and method. The Raman spectrum-based serum detection system comprisesa Raman detection device and a data processing system in signal connection with the Raman detection device, wherein the Raman detection device performs Raman spectrum sampling of multiple times and multiple sampling points on a serum sample, and transmits the acquired Raman spectrum data to the data processing system; and the data processing system receives the data, analyzes and processes an overall data mode presented by the data, adjusts sampling conditions in real time according to a processing result and realizes serum sample detection. The blood collection tube with obvious serum and blood clot upper and lower layering is directly used as a sample tube, and a machine learning model is adopted to realize intelligent identification of a serum mode / blood mixture mode of Raman spectrumdata so as to ensure that a sampling point is always located in a serum part used as a supernatant in the blood collection tube in height. The biological safety of sample preparation is improved, thesample preparation period is shortened, and meanwhile the data effectiveness of serum sample sampling is kept.

Description

Technical field [0001] The invention belongs to the field of spectrum analysis, and in particular relates to a serum detection system and method based on Raman spectroscopy. Background technique [0002] Raman Spectroscopy technology has been gradually applied in the field of medical testing, providing a non-destructive testing approach for qualitative and quantitative information on physiological samples to be tested. In the Raman testing of biological liquid samples, especially human serum samples, for biological safety considerations, it is often not recommended to use glass and other fragile material sample containers, but to use transparent polymer plastic containers, such as Biological sample tube made of polypropylene. However, in the Raman detection of serum samples, the noise signal introduced by this type of polymer plastic container due to its own material characteristics will seriously affect the signal-to-noise ratio of the Raman spectrum signal, making it difficult...

Claims

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Application Information

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IPC IPC(8): G01N21/65G01N21/01
CPCG01N21/65G01N21/01Y02A90/10
Inventor 尹愚
Owner CHENGDU PANOAI INTELLIGENT TECH CO LTD
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