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Application of traditional Chinese medicine composition containing radix astragali in regulating and controlling gastric cancer immune microenvironment

A composition and micro-environment technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve the problems of damaging yin, qi consumption, and kidney qi, so as to reduce malignant transformation and improve immunity Inhibition of Microenvironmental Effects

Inactive Publication Date: 2020-07-24
HANGZHOU THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment only serves the purpose of reducing tumors and eliminating evils, but does not fundamentally relieve the patient's imbalance of qi and blood, balance of yin and yang, and visceral function. Chemotherapy damages yin and consumes qi and damages kidney qi

Method used

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  • Application of traditional Chinese medicine composition containing radix astragali in regulating and controlling gastric cancer immune microenvironment
  • Application of traditional Chinese medicine composition containing radix astragali in regulating and controlling gastric cancer immune microenvironment
  • Application of traditional Chinese medicine composition containing radix astragali in regulating and controlling gastric cancer immune microenvironment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, Chinese medicine composition prescription and preparation method involved in the present invention

[0030] The prescription of the traditional Chinese medicine composition is composed of the following raw materials and contents:

[0031] Astragalus 20g, Ligustrum lucidum 12g, Poria cocos 12g, Polyporus 12g, Coix seed 30g, Lycium barbarum 12g, Banzhilian 30g, Tengli root 30g, Curcuma 10g, August Zha 10g, Red dates 30g, Zhigancao 6g, raw materials Both were purchased from Huadong Medicine Co., Ltd.

[0032] The preparation method of this Chinese medicine composition is as follows:

[0033] Put the prescribed amount of raw materials in a casserole, add 5 times the amount of medicinal materials to soak in cold water for 1 hour, boil for 30 minutes, add 3 times the amount of water and continue to decoct for 20 minutes, filter, combine the filtrates twice, and use the decoction obtained After concentrating with a rotary evaporator, add alcohol to adjust the e...

Embodiment 2

[0034] Embodiment 2, the influence of the prescription of the present invention on the quantity, morphological structure and metastasis ability of gastric cancer CSC

[0035] The human gastric cancer cell line SGC-7901 was selected and purchased from the Cell Bank of the Chinese Academy of Sciences. Experimental animals: 40 SD rats, 5-6 weeks old, male, SPF grade, body weight (200±20) g, provided by the Animal Experiment Center of Zhejiang University of Traditional Chinese Medicine.

[0036] 40 SD rats were randomly divided into the following groups: a blank control group, a positive control group, and a Chinese medicine group prepared according to the method in Example 1. The Chinese medicine group was given 30 g / kg of crude drug for intragastric administration, once a day, for 7 consecutive days ; The blank control group was given 0.9% normal saline at a dose of 0.5ml / rat, once a day for 7 consecutive days. Anesthetized by intraperitoneal injection 1 hour after the last adm...

Embodiment 3

[0063] Example 3, the influence of the prescription of the present invention on the proliferation, differentiation and metastasis of gastric cancer CSC

[0064] The human gastric cancer cell line SGC-7901 was labeled with luciferase (assisted by Shanghai Jikai Gene Co., Ltd.), and the cell line SGC-7901-luc stably expressing luciferase was constructed, which was used for real-time monitoring of transplanted tumors and Distant metastases. Experimental animals: 120 nude mice, 5-6 weeks old, male, provided by the Animal Experiment Center of Zhejiang University of Traditional Chinese Medicine.

[0065] In addition to the negative control group, 80 successful nude mice were randomly divided into 4 groups, namely the model control group, the prescription group of the present invention (Chinese medicine group), the chemotherapeutic drug 5-fluorouracil group (5-Fu group), the present invention Prescription + chemotherapeutic drug 5-Fu group (synergy group), 20 rats in each group. Dr...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition containing radix astragali in regulating and controlling a gastric cancer immune microenvironment. The traditionalChinese medicine composition is composed of the following components: 20 parts of radix astragali, 12 parts of glossy privet fruit, 12 parts of poria cocos, 12 parts of polyporus, 30 parts of semen coicis, 12 parts of fructus lycii, 30 parts of herba scutellariae barbatae, 30 parts of radix actinidiae chinensis, 10 parts of rhizoma curcumae, 10 parts of fiveleaf akebia fruit, 30 parts of red datesand 6 parts of radix glycyrrhizae preparata. According to the traditional Chinese medicine composition provided by the invention, a CSC immunosuppression microenvironment is improved and a Notch signal path is regulated and controlled by using the effect of of the prescription such as benefiting qi and tonifying and kidney and regulating and mobilizing an organism defense system, so that malignant transformation of CSC can be reduced, and even partial CSC in a dormant period recover the phenotype, and is transformed towards a normal somatic cell direction is realized.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to the application of a traditional Chinese medicine composition containing astragalus in regulating the immune microenvironment of gastric cancer. Background technique [0002] Gastric cancer is one of the most common malignant tumors of the digestive tract, and about 40% of new cases in the world occur in China every year [1] , its incidence rate ranks second in systemic malignant tumors, and its mortality rate ranks third. With the popularization of multidisciplinary comprehensive diagnosis and treatment ideas and the intervention of molecular targeted therapy, the treatment of gastric cancer has made great progress, but the overall five-year survival rate does not exceed 20%, of which more than 50% died of recurrence and metastasis [2] . Therefore, finding safe and effective methods and strategies to resist gastric cancer metastasis has become...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/00A61P35/00
CPCA61K36/07A61K36/076A61K36/185A61K36/481A61K36/484A61K36/539A61K36/638A61K36/725A61K36/815A61K36/8994A61K36/9066A61P1/00A61P35/00A61K2300/00
Inventor 刘云霞徐叶峰姚勇伟王翌庆蒋沈君王娜贾祯李梦芸
Owner HANGZHOU THIRD HOSPITAL
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